Chapter 2: An Introduction to Pharmacokinetics: From Conventional to Advanced Systemic Drug Delivery Systems

TALEVI ALAN; BRUNO BLANCH LUIS; CASTRO GUILLERMO R

Drug Delivery: An Integrated Clinical and Engineering Approach

CRC Press

Año: 2017; p. 13 - 45

An Overview of Some General Aspects of Conventional Drug Delivery Systems. Drug Absorption, Distribution, and Elimination. Drug Clearance: Metabolism and Excretion. Presystemic Metabolism. The One-Compartment Open Model.Administration Routes: Advantages and Limitations Related to ConventionalDelivery Systems.Oral Route: Enteral, Sublingual, and Buccal. Rectal Route. Parenteral Route. Transdermal Route. Advanced Drug Delivery (Micro and Nano) Systems. Nanosystems and Solubility and Absorption Issues. Nanosystems and Biodistribution. Nanosystems and Elimination. In Vivo Monitoring. Conclusions. References.