INVESTIGADORES
DIAZ Silvina Laura
capítulos de libros
Título:
5HTR2B, 5-Hydroxytryptamine Serotonin Receptor 2B
Autor/es:
MAROTEAUX L; ROUMIER A; DOLY S; DIAZ SL; BELMER A
Libro:
Encyclopedia of Signaling Molecules
Editorial:
Springer Link
Referencias:
Año: 2017;
Resumen:
Because of its exquisite sensitivity to serotonin, the rat stomach fundus was used as a bioassay for serotonin beforethe development of more quantitative analytical assays for this biogenic amine (Vane 1957). Although the potencyfor the contractile effects of serotonin has been known for long time, the receptors mediating such a response haveeluded definitive characterization for long time. Pharmacological studies attempting to characterize the contractileserotonergic receptor in the rat stomach fundus documented the similarity to the 5-HT2C receptor. In the absence ofdetectable 5-HT2C receptor mRNA in the rat stomach fundus, only molecular cloning allowed the identification of anew receptor in 1992 in rat and mouse (Foguet et al. 1992; Kursar et al. 1992; Loric et al. 1992; Wainscott et al.1993) and in 1994 in humans (Choi et al. 1994; Kursar et al. 1994; Schmuck et al. 1994; Wainscott et al. 1996), nowcalled 5-HT2B receptor. Subsequent pharmacological characterization of this receptor subtype in various speciesidentified differences in its pharmacology, and confirmed the close identity of this pharmacology to that of 5-HT2Creceptors. Its physiological and pathophysiological functions include many differentiation steps both in periphery andcentral nervous system that were not previously identified or attributed to other receptor subtypes.