Luteolin: cyto-genotoxic effects on normal cells

CARIDDI L; MONTIRONI I; SABINI C

Luteolin: Natural Occurrences, Therapeutic Applications and Health Effects

Nova Science Publishers Inc. Hauppauge

Año: 2015; p. 101 - 107

Luteolin belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. Different studies are focused on their benefical properties but little is know about the damage of this flavone in normal cells. The studies conducted in order to evaluate the cyto-genotoxic effects of luteolin on normal animal and human cells showed diverse results that reveal that this flavone could have toxic effects depending on diverse factors as concentration, test carried out (in vitro or in vivo), time and mode of admisistration and type of cell. Because there are many biological activities attributed to luteolin, some of which could be beneficial or detrimental depending on various aspects, further studies are required to ensure the security of this flavonoid for potencial future application in a host system.