The role of Angiotensin II AT1 receptors in the sympathoadrenal response to stress

ARMANDO, INÉS; CARRANZA, ANDREA; NISHIMURA, YASUAKI; HOE, KWANG LAE; BARONTINI, MARTA; SAAVEDRA, JUAN MARÍA

Catecholamine research: From Molecular Insights to Clinical Medicine

Kluver Academic / Plenum Publishers

Lugar: New York; Año: 2002; p. 313 - 316

    Armando I, Carranza A, Nishimura Y, Hoe K, Barontini M, Saavedra JM. The role of Angiotensin II AT1 receptors in the sympathoadrenal response to stress. In: Catecholamine Research: From Molecular Insights to Clinical Medicine. Advances in Behavioral Biology Series. Eds. Nagatsu T, Nabeshima T, McCarthy R, Goldstein DS, Kluver Academic/ Plenum Publishers: New York, 313-316, 2002. Angiotensin II (Ang II) is a hormone and brain neuropeptide implicated in the response of the hypothalamic-pituitary-adrenal axis to stress. Stress increases circulating Ang II and the expression of Ang II receptors in brain areas such as the hypothalamic paraventricular nucleus (PVN) is crucial for central control of the stress reaction. Because Ang II contributes to regulate the hormonal and sympathoadrenal system, and Ang II receptors are highly expressed at all levels of the hypothalamic-pituitary-adrenal axis, it was reasonable to postulate that blockade of the physiological active Ang II AT1 receptors could influence the outcome of the hormonal and sympathetic response to stress. We asked the question of how pretreatment with a peripheral and central Ang II AT1 receptor antagonist modulated the hypothalamo-pituitary-adrenal response to isolation stress. We found that pretreatment with candesertan almosy completely abolished the hormonal and sympathoadreanal response to isolation, suggesting that simultaneous antagonism of peripheral and brain AT1 is an adventage in the control of the stress reaction.