Early Activation of Intracellular Signals after Myocardial Stretch: Anrep Effect, Myocardial Hypertrophy and Heart Failure

CINGOLANI HE; VILLA ABRILLE MC; CALDIZ CI; ENNIS IL; CINGOLANI OA; MORGAN P; AIELLO EA; PÉREZ NG

Mechanically Gated Channels and their Regulation

Springer

Lugar: Moscú; Año: 2013;

The link between theAnrep effect and myocardial hypertrophy and failure, although 6 obvious–since this effect is the result of myocardial strain- was not appreciated untilobvious–since this effect is the result of myocardial strain- was not appreciated until 7 we proposed it in the 2005 edition of the book “Mechanosensitivity in Cells andwe proposed it in the 2005 edition of the book “Mechanosensitivity in Cells and 8 Tissues”. Previous experiments by Izumo and Sadoshima (Sadoshima et al. 1993),Tissues”. Previous experiments by Izumo and Sadoshima (Sadoshima et al. 1993), 9 Ito et al. (1993) and Yamazaki et al. (1996) performed in neonatal cardiomyocytesIto et al. (1993) and Yamazaki et al. (1996) performed in neonatal cardiomyocytes 10 showed that mechanical stretch induces the release of preformed angiotensin II (A2)showed that mechanical stretch induces the release of preformed angiotensin II (A2) 11 to the surrounding media, yet these findings were never linked to the Anrep effect,to the surrounding media, yet these findings were never linked to the Anrep effect, 12 a phenomenon originally described in the open chest dog model (von Anrep 1912).a phenomenon originally described in the open chest dog model (von Anrep 1912). 13 Furthermore, Ito et al. (1993) showed that in stretched-conditioned medium whereFurthermore, Ito et al. (1993) showed that in stretched-conditioned medium where 14 A2 was released, the hypertrophic signals were abolished by interfering with the en15A2 was released, the hypertrophic signals were abolished by interfering with the en15 dothelin (ET) action, finding that is in agreement with our own results demonstrating 16 that stretching adult myocardium releases A2 (or activation of the AT1 receptor bythat stretching adult myocardium releases A2 (or activation of the AT1 receptor by 17 deformation) triggering the release and/or formation of ET (for review see Cingolanideformation) triggering the release and/or formation of ET (for review see Cingolani 18 et al. 2011a).et al. 2011a).