INVESTIGADORES
ORTEGA Hugo Hector
capítulos de libros
Título:
Impaired proliferation as a component of the pathogenesis of follicular persistence associated to cystic ovarian disease
Autor/es:
SALVETTI NR; REY F; STANGAFERRO M; GIMENO EJ; AMWEG A; DIAZ, PU; ORTEGA HH
Libro:
Cell Proliferation: Process, Regulation and Disorders
Editorial:
Nova Science Publishers, Inc.
Referencias:
Lugar: New York; Año: 2013; p. 53 - 64
Resumen:
Folliculogenesis,
ovulation, and the subsequent formation of the corpus luteum are complex
processes that involve dramatic changes in ovarian cell function. Once
initiated, follicular growth is a continuous process without resting phases,
ending at ovulation. One of the main modifications in granulosa cell function
is the rapid switch from the highly proliferative stage characterizing
granulosa cells of preovulatory follicles to the non-proliferative, terminally
differentiated phase of luteal cells. Cell cycle regulation involves a balance
between several regulatory molecules, and can be altered by numerous external
signals in multiple steps. Cystic ovarian disease (COD) and/or polycystic
ovarian syndrome (PCOS) are disorders of the reproduction that affect many
species including cattle (COD) and human (PCOS) beings. In the bovine
livestock, this disease is an important cause of infertility and it is
characterized by anovulation, anoestrus, and the persistence of follicles with
a larger diameter than the ovulatory follicle. The combination of weak
proliferation indices and low apoptosis observed in follicular cysts, could
explain the cause of the slow growth of cystic follicles and the maintenance of
a static condition without degeneration, which leads to their persistence.
These alterations may be due to structural and functional modifications that
take place in these cells and could be related to hormonal changes in animals with
this condition.