BECAS
CAMBIASSO Maite Yael
capítulos de libros
Título:
Decondensation of Sperm Chromatin.
Autor/es:
CAMBIASSO MAITE YAEL; ROMANATO MARINA; PIÑEIRO DE CALVO LUCRECIA; CALVO JUAN CARLOS; FONTANA VANINA ANDREA
Libro:
Encyclopedia of Reproduction 3rd edition.
Editorial:
Academic Press
Referencias:
Año: 2024;
Resumen:
During sperm development, a highly condensed chromatin is formed due to the replacement of histones by other positively charged proteins: the protamines. This renders a stable yet transcriptionally inactive DNA which is carried by sperm to the fertilization site where the oocyte resides. After fertilization, chromatin decondensation must take place to form the male pronucleus. This is accomplished, in rodents, bovine and humans, by the concomitant action of glutathione and heparan sulfate, both present in the oocyte cytoplasm. Altered chromatin decondensation could lead to changes in gene regulation that may impact the offspring.
