MAILÍN CASADEI; BERNARDO MIGUEL; JULIA RUBIONE; ESTEBAN FIORE; DIEGO MENGELLE; ROBERTO A GUERRI-GUTTENBERG; ALEJANDRO MONTANER; MARCELO J VILLAR; LUIS CONSTANDIL-CÓRDOVA; ALFONSO E ROMERO-SANDOVAL; PABLO R BRUMOVSKY

Mesenchymal Stem Cell Engagement Modulates Neuroma Microenviroment in Rats and Humans and Prevents Postamputation Pain

Journal of Pain; Lugar: Philadelphia; Año: 2024

AGOSTINA M. ONORATO; LUCÍA LAMEROLI MAURIZ; JUAN BAYO; ESTEBAN FIORE; MARÍA JOSÉ CANTERO; BARBARA BUELONI; MARIANA GARCÍA; CECILIA LAGÜES; PEDRO MARTÍNEZ-DUARTEZ; GABRIEL MENALDI; NICOLAS PALEARI; CATALINA ATORRASAGASTI; GUILLERMO D. MAZZOLINI

Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Año: 2023 vol. 24

LUCIANA M. DOMÍNGUEZ; BÁRBARA BUELONI; MA. JOSÉ CANTERO; MILAGROS ALBORNOZ; NATALIA PACIENZA; CELESTE BIANI; CARLOS LUZZANI; SANTIAGO MIRIUKA; MARIANA GARCÍA; MARÍA CATALINA ATORRASAGASTI; GUSTAVO YANNARELLI; JUAN BAYO; ESTEBAN FIORE; GUILLERMO MAZZOLINI

Chromatographic Scalable Method to Isolate Engineered Extracellular Vesicles Derived from Mesenchymal Stem Cells for the Treatment of Liver Fibrosis in Mice

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Lugar: Basel; Año: 2023 vol. 24

CASADEI, MAILÍN; FIORE, ESTEBAN; RUBIONE, JULIA; DOMÍNGUEZ, LUCIANA MARÍA; CORONEL, MARÍA FLORENCIA; LEIGUARDA, CANDELARIA; GARCÍA, MARIANA; MAZZOLINI, GUILLERMO; VILLAR, MARCELO J.; MONTANER, ALEJANDRO; CONSTANDIL, LUIS; ROMERO-SANDOVAL, E ALFONSO; BRUMOVSKY, PABLO R.

IMT504 blocks allodynia in rats with spared nerve injury by promoting the migration of mesenchymal stem cells and by favoring an anti-inflammatory milieu at the injured nerve

Pain; Año: 2022 vol. 163 p. 1114 - 1129

DOMÍNGUEZ, LUCIANA M.; FIORE, ESTEBAN J.; MAZZOLINI, GUILLERMO D.

Generation and characterization of human mesenchymal stem/stromal cells for cell therapy applications

METHODS IN CELL BIOLOGY.; Año: 2022 vol. 170 p. 189 - 202

BUELONI, BARBARA; FIORE, ESTEBAN; GIDEKEL, MANUEL; BAYO, JUAN; MAZZOLINI, GUILLERMO

Evaluation of cancer stem cells markers expression in HCC trough real-time polymerase chain reaction

METHODS IN CELL BIOLOGY.; Año: 2022 vol. 171 p. 23 - 32

ONORATO, AGOSTINA; FIORE, ESTEBAN; BAYO, JUAN; CASALI, CECILIA; FERNANDEZ?TOMÉ, MARÍA; RODRÍGUEZ, MARCELO; DOMÍNGUEZ, LUCIANA; ARGEMI, JOSEPMARÍA; HIDALGO, FLORENCIA; FAVRE, CRISTIAN; GARCÍA, MARIANA; ATORRASAGASTI, CATALINA; MAZZOLINI, GUILLERMO D.

SPARC inhibition accelerates NAFLD‐associated hepatocellular carcinoma development by dysregulating hepatic lipid metabolism

LIVER INTERNATIONAL; Año: 2021

CIARLANTINI, MATÍAS S.; BARQUERO, ANDREA; BAYO, JUAN; WETZLER, DIANA; DODES TRAIAN, MARTÍN M.; BUCCI, HERNÁN A.; FIORE, ESTEBAN J.; GANDOLFI DONADÍO, LUCÍA; DEFELIPE, LUCAS; TURJANSKI, ADRIÁN; RAMÍREZ, JAVIER A.; MAZZOLINI, GUILLERMO; COMIN, MARIA J.

Development of an Improved Guanidine-Based Rac1 Inhibitor with in vivo Activity against Non-Small Cell Lung Cancer

CHEMMEDCHEM; Año: 2021 vol. 16 p. 1011 - 1021

RODRÍGUEZ, MARCELO M.; ONORATO, AGOSTINA; CANTERO, MARÍA JOSÉ; DOMÍNGUEZ, LUCIANA; BAYO, JUAN; FIORE, ESTEBAN; GARCÍA, MARIANA; ATORRASAGASTI, CATALINA; CANBAY, ALI; MALVICINI, MARIANA; MAZZOLINI, GUILLERMO D.

4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice

Scientific Reports; Año: 2021 vol. 11

CASADEI, MAILÍN; FIORE, ESTEBAN; RUBIONE, JULIA; DOMÍNGUEZ, LUCIANA MARÍA; CORONEL, MARÍA FLORENCIA; LEIGUARDA, CANDELARIA; GARCÍA, MARIANA; MAZZOLINI, GUILLERMO; VILLAR, MARCELO J.; MONTANER, ALEJANDRO; CONSTANDIL, LUIS; ROMERO-SANDOVAL, E. ALFONSO; BRUMOVSKY, PABLO R.

IMT504 blocks allodynia in rats with spared nerve injury by promoting the migration of mesenchymal stem cells and by favoring an anti-inflammatory milieu at the injured nerve

PAIN; Año: 2021 vol. 10

SIERRA, ROMINA; GÓMEZ BUSTILLO, SOFÍA; KAMENEVA, POLINA; FIORE, ESTEBAN J.; MAZZONE, GRACIELA L.; BORDA, MAXIMILIANO; BLANCO, MARÍA V.; USUARDI, CHIARA; FURLAN, ALESSANDRO; ERNFORS, PATRIK; ALANIZ, LAURA; MONTANER, ALEJANDRO D.; ADAMEYKO, IGOR; AQUINO, JORGE B.

Contribution of neural crest and GLAST+ Wnt1+ bone marrow pericytes with liver fibrogenesis and/or regeneration

LIVER INTERNATIONAL; Año: 2020 vol. 40 p. 977 - 987

FIORE, ESTEBAN J.; BAYO, JUAN; DOMINGUEZ, LUCIANA MARÍA; CANTERO, MARÍA JOSE; CIARLANTINI, MATIAS S.; MALVICINI, MARIANA; ATORRASAGASTI, CATALINA; GARCIA, MARIANA GABRIELA; ROSSI, MARIO; CAVASOTTO, CLAUDIO; MARTINEZ, ELISABETH; COMIN, JULIETA; MAZZOLINI, GUILLERMO D.

Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma

GUT - AN INTERNATIONAL JOURNAL OF GASTROENTEOROLOGY AND HEPATOLOGY; Año: 2020

DOMINGUEZ LUCIANA; FIORE, ESTEBAN J.; GUILLERMO D. MAZZOLINI

Mesenchymal stem/stromal cells. Its therapeutic potential in medicine

MEDICINA (BUENOS AIRES); Lugar: Buenos Aires; Año: 2020

BAYO, JUAN; FIORE, ESTEBAN J.; DOMINGUEZ, LUCIANA M.; REAL, ALEJANDRINA; MALVICINI, MARIANA; RIZZO, MANGLIO; ATORRASAGASTI, CATALINA; GARCÍA, MARIANA G.; ARGEMI, JOSEPMARIA; MARTINEZ, ELISABETH D.; MAZZOLINI, GUILLERMO D.

A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets

JOURNAL OF HEPATOLOGY; Año: 2019

ATORRASAGASTI, CATALINA; ONORATO, AGOSTINA; GIMENO, MARÍA L.; ANDREONE, LUZ; GARCIA, MARIANA; MALVICINI, MARIANA; FIORE, ESTEBAN; BAYO, JUAN; PERONE, MARCELO J.; MAZZOLINI, GUILLERMO D.

SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice

CLINICAL SCIENCE (LONDON, ENGLAND : 1979); Año: 2019 vol. 133 p. 351 - 365

SUKOWATI, CAECILIA H. C.; ANFUSO, BEATRICE; FIORE, ESTEBAN; IE, SUSAN I.; RASENI, ALAN; VASCOTTO, FULVIA; AVELLINI, CLAUDIO; MAZZOLINI, GUILLERMO; TIRIBELLI, CLAUDIO

Hyaluronic acid inhibition by 4-methylumbelliferone reduces the expression of cancer stem cells markers during hepatocarcinogenesis

Scientific Reports; Lugar: London; Año: 2019 vol. 9

FIORE, ESTEBAN; DOMÍNGUEZ, LUCIANA M.; BAYO, JUAN; MALVICINI, MARIANA; ATORRASAGASTI, CATALINA; RODRIGUEZ, MARCELO; CANTERO, MARÍA JOSÉ; GARCÍA, MARIANA; YANNARELLI, GUSTAVO; MAZZOLINI, GUILLERMO

Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

GENE THERAPY; Año: 2019

FIORE, ESTEBAN JUAN; DOMÍNGUEZ, LUCIANA MARÍA; BAYO, JUAN; GARCÍA, MARIANA GABRIELA; MAZZOLINI, GUILLERMO DANIEL

Taking advantage of the potential of mesenchymal stromal cells in liver regeneration: Cells and extracellular vesicles as therapeutic strategies

WORLD JOURNAL OF GASTROENTEROLOGY; Año: 2018 vol. 24 p. 2427 - 2440

RODRÍGUEZ, MARCELO M.; FIORE, ESTEBAN; BAYO, JUAN; ATORRASAGASTI, CATALINA; GARCÍA, MARIANA; ONORATO, AGOSTINA; DOMÍNGUEZ, LUCIANA; MALVICINI, MARIANA; MAZZOLINI, GUILLERMO

4Mu Decreases CD47 Expression on Hepatic Cancer Stem Cells and Primes a Potent Antitumor T Cell Response Induced by Interleukin-12

MOLECULAR THERAPY (PRINT); Año: 2018 vol. 26 p. 2738 - 2750

ESTEBAN FIORE; EDUARDO PICAZO; JORGE AQUINO; GUILLERMO MAZZOLINI

CÉLULAS MADRE MESENQUIMALES Y MEDICINA REGENERATIVA EN LA CIRROSIS HEPÁTICA

MEDICINA (BUENOS AIRES); Lugar: Buenos Aires; Año: 2017

ESTEBAN FIORE; MARIANA MALVICINI; JUAN BAYO; ESTANISLAO PEIXOTO; CATALINA ATORRASAGASTI; ROMINA SIERRA; MARCELO RODRIGUEZ; SOFÍA GOMEZ BUSTILLO; MARIANA GARCIA; JORGE AQUINO; GUILLERMO MAZZOLINI

Involvement of hepatic macrophages in the antifibrotic effect of IGF-I-overexpressing mesenchymal stromal cells.

Stem cell research and therapy; Lugar: Londres; Año: 2016 vol. 7

ESTANISLAO PEIXOTO; CATALINA ATORRASAGASTI; MARIANA MALVICINI; ESTEBAN FIORE; MARCELO RODRIGUEZ; MARIANA GARCIA; PAOLA FINOCCHIETO; JUAN J. PODEROSO; FERNANDO CORRALES; GUILLERMO MAZZOLINI

SPARC gene deletion protects against toxic liver injury and is associated to an enhanced proliferative capacity and reduced oxidative stress response

Oncotarget; Lugar: Nueva York; Año: 2016

JUAN BAYO; ALEJANDRINA REAL; ESTEBAN FIORE; MARIANA MALVICINI; LEONARDO SGANGA; MARCELA BOLONTRADE; ADRIANI OSCAR; CAROLINA BIZAMA; CRISTÓBAL FRESNO; OSVALDO PODHAJCER; ELMER FERNANDEZ; MANUEL GIDEKEL; GUILLERMO D. MAZZOLINI; MARIANA G. GARCÍA

IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness.

Oncotarget; Lugar: Nueva York ; Año: 2016

GUILLERMINA LUQUE; FELICITAS LOPEZ-VICCHI; ANA MARÍA ORNSTEIN; BELÉN BRIE; CATALINA DE WINNE; ESTEBAN FIORE; MARÍA ÏNÉS PEREZ-MILLAN; GUILLERMO MAZZOLINI; MARCELO RUBINSTEIN; DAMASIA BECU-VILLALOBOS

Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM; Lugar: Bethesda; Año: 2016 vol. 311 p. 974 - 988

FLAVIA PICCIONI; ESTEBAN FIORE; JUAN BAYO; CATALINA ATORRASAGASTI; ESTANISLAO PEIXOTO; MIGUEL RIZZO; MARIANA MALVICINI; TIRADO-GONZALES; MARIANA G. GARCÍA; LAURA ALANIZ; GUILLERMO MAZZOLINI

4-Methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis

GLYCOBIOLOGY; Lugar: Oxford; Año: 2015

MARIANA MALVICINI; ESTEBAN FIORE; GHIACCIO VALENTINA; FLAVIA PICCIONI; MIGUEL RIZZO; BONADEO; MARIANA G. GARCÍA; RODRIGUEZ MARCELO; JUAN BAYO; ESTANISLAO PEIXOTO; CATALINA ATORRASAGASTI; LAURA ALANIZ; JORGE AQUINO; PABLO MATAR; GUILLERMO MAZZOLINI

"Tumor microenvironment remodeling by 4-methylumbelliferone boosts the antitumor effect of combined immunotherapy in murine colorectal carcinoma".

MOLECULAR THERAPY (PRINT); Lugar: San Diego, CA ; Año: 2015

ESTEBAN FIORE; GUILLERMO MAZZOLINI; JORGE AQUINO

Mesenchymal Stem/Stromal Cells in Liver Fibrosis: Recent Findings, Old/New Caveats and Future Perspectives.

STEM CELL REVIEWS AND REPORTS; Lugar: HEIDELBERG; Año: 2015

ESTEBAN FIORE; JUAN BAYO; JORGE AQUINO; MARIANA MALVICINI; MIGUEL RIZZO; ESTANISLAO PEIXOTO; ADRIANI OSCAR; LAURA ALANIZ; FLAVIA PICCIONI; MARCELA BOLONTRADE; OSVALDO PODHAJCER; MARIANA G. GARCÍA; GUILLERMO MAZZOLINI

Increased migration of human mesenchymal stromal cells by autocrine motility factor (AMF) resulted in enhanced recruitment towards hepatocellular carcinoma.

PLOS ONE; Lugar: San Francisco; Año: 2014

ESTANISLAO PEIXOTO; CATALINA ATORRASAGASTI; JORGE B. AQUINO; MILITELO RODRIGO; JUAN BAYO; ESTEBAN FIORE; FLAVIA PICCIONI; SALVATIERRA EDGARDO; LAURA ALANIZ; MARIANA G. GARCÍA; RAMÓN BATALLER; FERNANDO CORRALES; MANUEL GIDEKEL; OSVALDO PODHAJCER; COLOMBO MI; GUILLERMO MAZZOLINI

SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage.

GENE THERAPY; Lugar: Londres; Año: 2014

ESTEBAN FIORE; JUAN BAYO; MARIANA GARCIA; MARIANA MALVICINI; RODRIGO LLOYD; FLAVIA PICCIONI; MIGUEL RIZZO; ESTANISLAO PEIXOTO; BEATRÍZ SOLÁ; CATALINA ATORRASAGASTI; LAURA ALANIZ; CAMILLETI MARIA ANDREA; MONICA ENGUITA; JESÚS PRIETO; JORGE AQUINO; GUILLERMO MAZZOLINI

Mesenchymal stromal cells engineered to produce IGF-I by recombinant adenovirus ameliorate liver fibrosis in mice.

STEM CELLS AND DEVELOPMENT; Lugar: New York; Año: 2014

JUAN BAYO; ESTEBAN FIORE; JORGE AQUINO; MARIANA MALVICINI; MIGUEL RIZZO; ESTANISLAO PEIXOTO; LAURA ALANIZ; FLAVIA PICCIONI; MARCELA BOLONTRADE; OSVALDO PODHAJCER; MARIANA G. GARCÍA; GUILLERMO MAZZOLINI

Human umbilical cord perivascular cells exhibited enhanced migration capacity towards hepatocellular carcinoma in comparison with bone marrow mesenchymal stromal cells: a role for autocrine motility factor receptor.

Biomed Res Int; Año: 2014

MIGUEL RIZZO; JUAN BAYO; FLAVIA PICCIONI; MARIANA MALVICINI; ESTEBAN FIORE; ESTANISLAO PEIXOTO; MARIANA G. GARCÍA; JORGE AQUINO; GONZALEZ CAMPAÑA A; PODESTÀ G; M. TERREZ; ADRIANI OSCAR; LAURA ALANIZ; GUILLERMO MAZZOLINI

Low molecular weight hyaluronan-pulsed human dendritic cells showed increased migration capacity and induced resistance to tumor chemoattraction.

PLOS ONE; Lugar: San Francisco; Año: 2014

CATALINA ATORRASAGASTI; ESTANISLAO PEIXOTO; JORGE AQUINO; NESTOR KIPPES; MARIANA MALVICINI; LAURA ALANIZ; MARIANA GARCIA; FLAVIA PICCIONI; ESTEBAN FIORE; JUAN BAYO; RAMÓN BATALLER; ELIZABETH GURUCEAGA; FERNANDO CORRALES; OSVALDO PODHAJCER; GUILLERMO MAZZOLINI

Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.

PLOS ONE; Lugar: San Francisco; Año: 2013 vol. 8

MARIANA MALVICINI; LAURA ALANIZ; JUAN BAYO; MARIANA G. GARCÍA; FLAVIA PICCIONI; ESTEBAN FIORE; CATALINA ATORRASAGASTI; JORGE AQUINO; PABLO MATAR; GUILLERMO MAZZOLINI

Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice.

OncoImmunology; Año: 2012 p. 1038 - 1047

MARIANA MALVICINI; FLAVIA PICCIONI ; JUAN BAYO; ESTEBAN FIORE; CATALINA ATORRASAGASTI; LAURA ALANIZ; MARIANA GARCIA; JORGE B. AQUINO ; MANUEL GIDEKEL; PABLO MATAR; GUILLERMO MAZZOLINI

Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide

OncoImmunology; Año: 2012 p. 1626 - 1628

MARIANA G. GARCÍA; JUAN BAYO; MARCELA BOLONTRADE; LEONARDO SGANGA; MARIANA MALVICINI; LAURA ALANIZ; JORGE AQUINO; ESTEBAN FIORE; MIGUEL RIZZO; ANDREZ RODRIGUEZ; ALICIA LORENTI; OSCAR ANDRIANI; OSVALDO PODHAJCER; GUILLERMO MAZZOLINI

Hepatocellular carcinoma cells and its fibrotic microenvironment differentially modulate bone marrow-derived mesenchymal stromal cells migration in vitro and in vivo

MOLECULAR PHARMACOLOGY; Lugar: Baltimore; Año: 2011 p. 1538 - 1548