FANGQI ZHAO; ANN-CHRISTIN TALLAREK; YIRU WANG; YIRAN XIE; ANKE DIEMERT; ALICE LU-CULLIGAN; PAVITHRA VIJAYAKUMAR; ENRICO KITTMANN; CHRISTOPHER URBSCHAT; JUAN BAYO; PETRA C. ARCK; SHELLI F. FARHADIAN; GABRIELA S. DVEKSLER; MARIANA GARCIA; SANDRA BLOIS

A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface

Frontiers in Immunology; Año: 2023 vol. 14

DOMINGUEZ, LUCIANA M.; BUELONI, BARBARA; CANTERO, MARÍA JOSÉ; MILAGRO, ALBORNOZ; NATALIA PACIENZA; CARLOS LUZZANI; SANTIAGO MIRIUKA; MARIANA GARCIA; CATALINA ATORRASAGASTI; GUSTAVO YANARELLI; JUAN BAYO; ESTEBAN FIORE; GUILLERMO MAZZOLINI

Chromatographic Scalable Method to Isolate Engineered Extracellular Vesicles Derived from Mesenchymal Stem Cells for the Treatment of Liver Fibrosis in Mice

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Lugar: Basel; Año: 2023 vol. 24

AGOSTINA ONORATO; LUCIA LAMEROLI; JUAN BAYO; ESTEBAN FIORE; MARIA JOSE CANTERO; BARBARA BUELONI; MARIANA GARCIA; CECILIA LAGUES; PEDRO MARTÍNEZ-DUARTEZ; GABRIEL MENALDI; NICOLAS PALEARI ; CATALINA ATORRASAGASTI ; GUILLERMO D. MAZZOLINI

Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Año: 2023 vol. 24

BUELONI, BARBARA; FIORE, ESTEBAN; GIDEKEL, MANUEL; BAYO, JUAN, CO-SENIOR AUTHOR, CORRESPONDING AUTHOR; MAZZOLINI, GUILLERMO, CO-SENIOR AUTHOR, CORRESPONDING AUTHOR

Evaluation of cancer stem cells markers expression in HCC trough real-time polymerase chain reaction

METHODS IN CELL BIOLOGY.; Año: 2022 vol. 171 p. 23 - 32

CIARLANTINI, MATÍAS S.; BARQUERO, ANDREA; BAYO, JUAN; WETZLER, DIANA; DODES TRAIAN, MARTÍN M.; BUCCI, HERNÁN A.; FIORE, ESTEBAN J.; GANDOLFI DONADÍO, LUCÍA; DEFELIPE, LUCAS; TURJANSKI, ADRIÁN; RAMÍREZ, JAVIER A.; MAZZOLINI, GUILLERMO; COMIN, MARIA J.

Development of an Improved Guanidine-Based Rac1 Inhibitor with in vivo Activity against Non-Small Cell Lung Cancer

CHEMMEDCHEM; Año: 2021 vol. 16 p. 1011 - 1021

RODRÍGUEZ, MARCELO M.; ONORATO, AGOSTINA; CANTERO, MARÍA JOSÉ; DOMÍNGUEZ, LUCIANA; BAYO, JUAN; FIORE, ESTEBAN; GARCÍA, MARIANA; ATORRASAGASTI, CATALINA; CANBAY, ALI; MALVICINI, MARIANA; MAZZOLINI, GUILLERMO D.

4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice

Scientific Reports; Lugar: London; Año: 2021 vol. 11

ONORATO, AGOSTINA; FIORE, ESTEBAN; BAYO, JUAN; CASALI, CECILIA; FERNANDEZ?TOMÉ, MARÍA; RODRÍGUEZ, MARCELO; DOMÍNGUEZ, LUCIANA; ARGEMI, JOSEPMARÍA; HIDALGO, FLORENCIA; FAVRE, CRISTIAN; GARCÍA, MARIANA; ATORRASAGASTI, CATALINA; MAZZOLINI, GUILLERMO D.

SPARC inhibition accelerates NAFLD‐associated hepatocellular carcinoma development by dysregulating hepatic lipid metabolism

LIVER INTERNATIONAL; Año: 2021

LEIGUARDA, C.; VILLARREAL, A.; POTILINSKI, C.; PELISSIER, T.; CORONEL, M.F.; BAYO, J.; RAMOS, A.J.; MONTANER, A.; VILLAR, M.J.; CONSTANDIL, L.; BRUMOVSKY, PABLO R.

Intrathecal Administration of an Anti‐nociceptive Non-CpG Oligodeoxynucleotide Reduces Glial Activation and Central Sensitization

JOURNAL OF NEUROIMMUNE PHARMACOLOGY; Año: 2021

ATORRASAGASTI, CATALINA; PICCIONI, FLAVIA; BOROWSKI, SOPHIA; TIRADO-GONZÁLEZ, IRENE; FREITAG, NANCY; CANTERO, MARÍA JOSÉ; BAYO, JUAN; MAZZOLINI, GUILLERMO; ALANIZ, LAURA D.; BLOIS, SANDRA M.; GARCIA, MARIANA G.

Acceleration of taa-induced liver fibrosis by stress exposure is associated with upregulation of nerve growth factor and glycopattern deviations

International Journal of Molecular Sciences; Año: 2021 vol. 22

BAYO, JUAN; FIORE, ESTEBAN J.; DOMINGUEZ, LUCIANA MARÍA; CANTERO, MARÍA JOSE; CIARLANTINI, MATIAS S.; MALVICINI, MARIANA; ATORRASAGASTI, CATALINA; GARCIA, MARIANA GABRIELA; ROSSI, MARIO; CAVASOTTO, CLAUDIO; MARTINEZ, ELISABETH; COMIN, JULIETA; MAZZOLINI, GUILLERMO D.

Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma

GUT - AN INTERNATIONAL JOURNAL OF GASTROENTEOROLOGY AND HEPATOLOGY; Año: 2020

GUILLERMO MAZZOLINI; ALEXIS IRACHETA; MALVICINI, MARIANA; BAYO JUAN

Immunotherapy for Hepatocellular Carcinoma: Is Latin America Ready for Primetime?

Clin Liver Dis (Hoboken); Año: 2020

HYDER, USMAN; MCCANN, JENNIFER L.; WANG, JINLI; FUNG, VICTOR; BAYO, JUAN; D'ORSO, IVÁN

The ARF tumor suppressor targets PPM1G/PP2Cγ to counteract NF-κB transcription tuning cell survival and the inflammatory response

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2020 vol. 117 p. 32594 - 32605

GUILLERMO MAZZOLINI; ALEXIS IRACHETA; MARIANA MALVICINI; JUAN BAYO

Immunotherapy for Hepatocellular Carcinoma: Is Latin America Ready for Primetime?

Clinical Liver Disease; Año: 2020 vol. 16 p. 96 - 100

ESTEBAN FIORE* (IGUAL CONTRIBUCIÓN); LUCIANA DOMINGUES (IGUAL CONTRIBUCIÓN); JUAN BAYO; MARIANA MALVICINI; CATALINA ATORRASAGASTI; MARCELO RODRIGUEZ; MARIA JOSE CANTERO; MARIANA GARCIA; GUSTAVO YANARELLI; GUILLERMO MAZZOLINI

Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

GENE THERAPY; Año: 2020 vol. 27 p. 62 - 73

BACON, CURTIS W.; CHALLA, ASHWINI; HYDER, USMAN; SHUKLA, ASHUTOSH; BORKAR, ADITI N.; BAYO, JUAN; LIU, JIUYANG; WU, SHWU-YUAN; CHIANG, CHENG-MING; KUTATELADZE, TATIANA G.; D ORSO, IVÁN

KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs

MOLECULAR CELL; Año: 2020

FIORE, ESTEBAN; DOMÍNGUEZ, LUCIANA M.; BAYO, JUAN; MALVICINI, MARIANA; ATORRASAGASTI, CATALINA; RODRIGUEZ, MARCELO; CANTERO, MARÍA JOSÉ; GARCÍA, MARIANA; YANNARELLI, GUSTAVO; MAZZOLINI, GUILLERMO

Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

GENE THERAPY; Año: 2019

ATORRASAGASTI, CATALINA; ONORATO, AGOSTINA; GIMENO, MARÍA L.; ANDREONE, LUZ; GARCIA, MARIANA; MALVICINI, MARIANA; FIORE, ESTEBAN; BAYO, JUAN; PERONE, MARCELO J.; MAZZOLINI, GUILLERMO D.

SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice

CLINICAL SCIENCE (LONDON, ENGLAND : 1979); Año: 2019 vol. 133 p. 351 - 365

BAYO, JUAN; FIORE, ESTEBAN J.; DOMINGUEZ, LUCIANA M.; REAL, ALEJANDRINA; MALVICINI, MARIANA; RIZZO, MANGLIO; ATORRASAGASTI, CATALINA; GARCÍA, MARIANA G.; ARGEMI, JOSEPMARIA; MARTINEZ, ELISABETH D.; MAZZOLINI, GUILLERMO D.

A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets

JOURNAL OF HEPATOLOGY; Año: 2019

BAYO, JUAN; TRAN, TRAM ANH; WANG, LEI; PEÑA-LLOPIS, SAMUEL; DAS, AMIT K.; MARTINEZ, ELISABETH D.

Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks

Cell Reports; Año: 2018 vol. 25 p. 1040 - 1050

RODRÍGUEZ, MARCELO M.; FIORE, ESTEBAN; BAYO, JUAN; ATORRASAGASTI, CATALINA; GARCÍA, MARIANA; ONORATO, AGOSTINA; DOMÍNGUEZ, LUCIANA; MALVICINI, MARIANA; MAZZOLINI, GUILLERMO

4Mu Decreases CD47 Expression on Hepatic Cancer Stem Cells and Primes a Potent Antitumor T Cell Response Induced by Interleukin-12

MOLECULAR THERAPY (PRINT); Año: 2018 vol. 26 p. 2738 - 2750

FIORE, ESTEBAN JUAN; DOMÍNGUEZ, LUCIANA MARÍA; BAYO, JUAN; GARCÍA, MARIANA GABRIELA; MAZZOLINI, GUILLERMO DANIEL

Taking advantage of the potential of mesenchymal stromal cells in liver regeneration: Cells and extracellular vesicles as therapeutic strategies

WORLD JOURNAL OF GASTROENTEROLOGY; Año: 2018 vol. 24 p. 2427 - 2440

BAYO, JUAN; MAZZOLINI, GUILLERMO DANIEL

Epigenetics and hepatocellular carcinoma: ¿a therapeutic opportunity?

MEDICINA (BUENOS AIRES); Lugar: Buenos Aires; Año: 2018

DALVI, MAITHILI P.; WANG, LEI; ZHONG, RUI; KOLLIPARA, RAHUL K.; PARK, HYUNSIL; BAYO, JUAN; YENERALL, PAUL; ZHOU, YUNYUN; TIMMONS, BRENDA C.; RODRIGUEZ-CANALES, JAIME; BEHRENS, CARMEN; MINO, BARBARA; VILLALOBOS, PAMELA; PARRA, EDWIN R.; SURAOKAR, MILIND; PATAER, APAR; SWISHER, STEPHEN G.; KALHOR, NEDA; BHANU, NATARAJAN V.; GARCIA, BENJAMIN A.; HEYMACH, JOHN V.; COOMBES, KEVIN; XIE, YANG; GIRARD, LUC; GAZDAR, ADI F.; KITTLER, RALF; WISTUBA, IGNACIO I.; MINNA, JOHN D.; MARTINEZ, ELISABETH D.

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors

Cell Reports; Año: 2017 vol. 19 p. 1669 - 1684

JUAN BAYO; ALEJANDRINA REAL; ESTEBAN FIORE; LEONARDO SGANGA; MARCELA BOLONTRADE; OSCAR ANDRIANI; CAROLINA BIZAMA; FRESNO CRISTOBAL; OSVALDO PODHAJCER; ELMER FERNANDEZ; MANUEL GIDEKEL; GUILLERMO MAZZOLINI; MARIANA GARCIA

IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness

Oncotarget; Año: 2016

ESTEBAN FIORE; MARIANA MALVICINI; JUAN BAYO; ESTANISLAO PEIXOTO; CATALINA ATORRASAGASTI; ROMINA SIERRA; MARCELO RODRIGUEZ; SOFIA GOMEZ-BUSTILLO; MARIANA GARCIA; JORGE B. AQUINO; GUILLERMO MAZZOLINI

Involvement of hepatic macrophages in the antifibrotic effect of IGF-I-overexpressing mesenchymal stromal cells.

Stem cell research & therapy; Lugar: Londres; Año: 2016 vol. 7

JUAN BAYO* (IGUAL CONTRIBUCIÓN); ESTEBAN FIORE* (IGUAL CONTRIBUCIÓN); MARIANA GARCIA; MARIANA MALVICINI; RODRIGO LLOYD; FLAVIA PICCIONI; MANGLIO RIZZO; ESTANISLAO PEIXOTO; SOLA M. BEATRIZ; CATALINA ATORRASAGASTI; LAURA ALANIZ; MARÍA A. CAMILLETTI; MÓNICA ENGUITA; PRIETO JESUS; JORGE B. AQUINO; GUILLERMO MAZZOLINI

Mesenchymal Stromal Cells Engineered to Produce IGF-I by Recombinant Adenovirus Ameliorate Liver Fibrosis in Mice

STEM CELLS AND DEVELOPMENT; Lugar: New York; Año: 2015 vol. 24 p. 791 - 801

MARIANA MALVICINI; ESTEBAN FIORE; VALENTINA GHIACCIO; FLAVIA PICCIONI; MANGLIO RIZZO; LUCILA OLMEDO BONADEO; MARIANA GARCIA; MARCELO RODRIGUEZ; JUAN BAYO; ESTANISLAO PEIXOTO; CATALINA ATORRASAGASTI; LAURA ALANIZ; JORGE B. AQUINO; PABLO MATAR; GUILLERMO MAZZOLINI

Tumor microenvironment remodeling by 4-methylumbelliferone boosts the antitumor effect of combined immunotherapy in murine colorectal carcinoma

MOLECULAR THERAPY (PRINT); Lugar: Londres; Año: 2015

FLAVIA PICCIONI; ESTEBAN FIORE; JUAN BAYO; CATALINA ATORRASAGASTI; ESTANISLAO PEIXOTO; MANGLIO RIZZO; MARIANA MALVICINI; IRENE TIRADO-GONZALEZ; MARIANA GARCIA; LAURA ALANIZ; GUILLERMO MAZZOLINI

4-Methylumbelliferone inhibits hepatocellular carcinoma growths by decreasing IL-6 production and angiogenesis.

GLYCOBIOLOGY; Lugar: Oxford; Año: 2015

PHILIPP SCHNEIDER; JUAN BAYO; RAJEEV SINGH; PAVAN KUMAR DHANYAMRAJU; PHILIPP HOLZ; ANINJA BAIER; VOLKER FENDRICH; ANNETTE RAMASWAMY; STEFAN BAUMEISTER; ELISABETH D. MARTINEZ; MATTHIAS LAUTH

Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1

NATURE COMMUNICATIONS; Lugar: Londres; Año: 2015

JUAN BAYO; MAITHILI P DALVI; ELISABETH D MARTINEZ

Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential

Future medicinal chemistry; Lugar: Londres; Año: 2015 vol. 7 p. 2243 - 2261

JUAN BAYO* (IGUAL CONTRIBUCIÓN); ESTEBAN FIORE* (IGUAL CONTRIBUCIÓN); JORGE B. AQUINO; MARIANA MALVICINI; MANGLIO RIZZO; ESTANISLAO PEIXOTO; OSCAR ANDRIANI; LAURA ALANIZ; FLAVIA PICCIONI; MARCELA BOLONTRADE; OSVALDO PODHAJCER; MARIANA GARCIA; GUILLERMO MAZZOLINI

Increased Migration of Human Mesenchymal Stromal Cells by Autocrine Motility Factor (AMF) Resulted in Enhanced Recruitment towards Hepatocellular Carcinoma

PLOS ONE; Lugar: San Francisco; Año: 2014

JUAN BAYO; ESTEBAN FIORE; JORGE B. AQUINO; MARIANA MALVICINI; MANGLIO RIZZO; ESTANISLAO PEIXOTO; LAURA ALANIZ; FLAVIA PICCIONI; MARCELA BOLONTRADE; OSVALDO PODHAJCER; MARIANA GARCIA; GUILLERMO MAZZOLINI

Human Umbilical Cord Perivascular Cells Exhibited Enhanced Migration Capacity towards Hepatocellular Carcinoma in Comparison with Bone Marrow Mesenchymal Stromal Cells: A Role for Autocrine Motility Factor Receptor

BioMed Research International; Lugar: New York; Año: 2014

MANGLIO RIZZO; JUAN BAYO; FLAVIA PICCIONI; MARIANA MALVICINI; ESTEBAN FIORE; ESTANISLAO PEIXOTO; MARIANA GARCIA; JORGE B. AQUINO; ARIEL G. CAMPAÑA; GUSTAVO PODESTA; MARCELO TERRES; OSCAR ANDRIANI; LAURA ALANIZ; GUILLERMO MAZZOLINI

Low Molecular Weight Hyaluronan-Pulsed Human Dendritic Cells Showed Increased Migration Capacity and Induced Resistance to Tumor Chemoattraction

PLOS ONE; Lugar: San Francisco; Año: 2014

ESTANISLAO PEIXOTO; CATALINA ATORRASAGASTI; JORGE B. AQUINO; RODRIGO MILITELLO; JUAN BAYO; ESTEBAN FIORE; FLAVIA PICCIONI; EDGARDO SALVATIERRA; LAURA ALANIZ; MARIANA GARCIA; RAMON BATALLER; FERNANDO CORRALES; MANUEL GIDEKEL; OSVALDO PODHAJCER; MARIA I. COLOMBO; GUILLERMO MAZZOLINI

SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage

GENE THERAPY; Lugar: Londres; Año: 2014 vol. 22 p. 9 - 9

CATALINA ATORRASAGASTI; ESTANISLAO PEIXOTO; JORGE B. AQUINO; NESTOR KIPPES; MARIANA MALVICINI; LAURA ALANIZ; MARIANA GARCIA; FLAVIA PICCIONI; ESTEBAN FIORE; JUAN BAYO; RAMON BATALLER; ELIZABETH GURUCEAGA; FERNANDO CORRALES; OSVALDO PODHAJCER; GUILLERMO MAZZOLINI

Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.

PLOS ONE; Lugar: San Francisco; Año: 2013 vol. 8 p. 1 - 35

JUAN BAYO; MARIANO MARRODAN; JORGE B. AQUINO; MARCELO SILVA; MARIANA GARCIA; GUILLERMO MAZZOLINI

The therapeutic potential of bone marrow-derived mesenchymal stromal cells on hepatocellular carcinoma

LIVER INTERNATIONAL; Lugar: Londres; Año: 2013

MARIANA MALVICINI; LAURA ALANIZ; JUAN BAYO; MARIANA GARCIA; FLAVIA PICCIONI; ESTEBAN FIORE; CATALINA ATORRASAGASTI; JORGE B. AQUINO; PABLO MATAR; GUILLERMO MAZZOLINI

Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice.

Oncoimmunology; Año: 2012 vol. 1 p. 1038 - 1047

FLAVIA PICCIONI; MARIANA MALVICINI; MARIANA GARCIA; ANDRES RODRIGUEZ; CATALINA ATORRASAGASTI; NESTOR KIPPES; IGNACIO PIEDRA BUENA; MANGLIO RIZZO; JUAN BAYO; JORGE B. AQUINO; MANUEL VIOLA; ALBERTO PASSI; LAURA ALANIZ; GUILLERMO MAZZOLINI

Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice

GLYCOBIOLOGY; Lugar: Oxford; Año: 2012 p. 400 - 410

MARIANA MALVICINI; FLAVIA PICCIONI; JUAN BAYO; ESTEBAN FIORE; CATALINA ATORRASAGASTI; LAURA ALANIZ; MARIANA GARCIA; JORGE B. AQUINO; MANUEL GIDEKEL; PABLO MATAR; GUILLERMO MAZZOLINI

Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide

Oncoimmunology; Año: 2012 vol. 1 p. 1626 - 1628

JUAN BAYO* (IGUAL CONTRIBUCIÓN); MARIANA GARCIA* (IGUAL CONTRIBUCIÓN); MARCELA BOLONTRADE; LEONARDO SGANGA; MARIANA MALVICINI; LAURA ALANIZ; JORGE B. AQUINO; ESTEBAN FIORE; MANGLIO RIZZO; ANDRES RODRIGUEZ; ALICIA LORENTI; OSCAR ANDRIANI; OSVALDO PODHAJCER; GUILLERMO MAZZOLINI

Hepatocellular Carcinoma Cells and Their Fibrotic Microenvironment Modulate Bone Marrow-Derived Mesenchymal Stromal Cell Migration in Vitro and in Vivo

MOLECULAR PHARMACOLOGY; Lugar: Baltimore; Año: 2011 vol. 8 p. 1538 - 1548

MARIANA MALVICINI; MARIANA INGOLOTTI; FLAVIA PICCIONI; MARIANA GARCIA; JUAN BAYO; CATALINA ATORRASAGASTI; LAURA ALANIZ; JORGE B. AQUINO; JAIME A. ESPINOZA; MANUEL GIDEKEL; O. GRACIELA SCHAROVSKY; PABLO MATAR; GUILLERMO MAZZOLINI

Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12

MOLECULAR ONCOLOGY; Lugar: Amsterdam; Año: 2011 vol. 5 p. 242 - 255

LAURA ALANIZ; MANGLIO RIZZO; MARIANA GARCIA; FLAVIA PICCIONI; JORGE B. AQUINO; MARIANA MALVICINI; CATALINA ATORRASAGASTI; JUAN BAYO; ITZIAR ECHEVERRIA; PABLO SAROBE; GUILLERMO MAZZOLINI

Low molecular weight hyaluronan preconditioning of tumor-pulsed dendritic cells increases their migratory ability and induces immunity against murine colorectal carcinoma

CANCER IMMUNOLOGY IMMUNOTHERAPY; Lugar: Berlin; Año: 2011