CHARIF, SANTIAGO E.; VASSALLU, M. FLORENCIA; SALVAÑAL, LARA; IGAZ, LIONEL M.

Protein synthesis modulation as a therapeutic approach for amyotrophic lateral sclerosis and frontotemporal dementia

NEURAL REGENERATION RESEARCH; Año: 2022 vol. 17 p. 1423 - 1430

WIES MANCINI, VICTORIA S. B.; DI PIETRO, ANABELLA A.; DE OLMOS, SOLEDAD; SILVA PINTO, PABLO; VENCE, MARIANELA; MARDER, MARIEL; IGAZ, LIONEL M.; MARCORA, MARÍA S.; PASQUINI, JUANA M.; CORREALE, JORGE D.; PASQUINI, LAURA A.

Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model

JOURNAL OF NEUROCHEMISTRY; Año: 2022 vol. 160 p. 643 - 661

BERARDINO, BRUNO G.; BALLARINI, FABRICIO; CHERTOFF, MARIELA; IGAZ, LIONEL M.; CÁNEPA, EDUARDO T.

Nutritional stress timing differentially programs cognitive abilities in young adult male mice

NUTRITIONAL NEUROSCIENCE; Año: 2020 p. 1 - 13

CHARIF S; LUCHELLI L; VILA A; BLAUSTEIN M; IGAZ LM

Cytoplasmic expression of the ALS/FTD-related protein TDP-43 decreases global translation both in vitro and in vivo.

Frontiers in Cellular Neuroscience; Año: 2020

SILVA, PABLO R.; NIEVA, GABRIELA V.; IGAZ, LIONEL M.

Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice

Frontiers in Genetics; Año: 2019 vol. 10

ALFIERI JA; SILVA PR; IGAZ LM

Early cognitive/social deficits and late motor phenotype in conditional wild-type TDP-43 transgenic mice

Frontiers in Aging Neuroscience; Año: 2016

GONZALEZ MC; VILLAR ME; IGAZ LM; VIOLA H; MEDINA JH

Dorsal medial prefrontal cortex contributes to conditioned taste aversion memory consolidation and retrieval

NEUROBIOLOGY OF LEARNING AND MEMORY; Año: 2015 vol. 126 p. 1 - 6

ALFIERI JA; PINO DELGADO N; IGAZ LM

Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies

JOURNAL OF NEUROSCIENCE; Lugar: Washington; Año: 2014 vol. 34 p. 15244 - 15259

IGAZ LM; KWONG LK; LEE EB; CHEN-PLOTKIN A; SWANSON E; UNGER TL; MALUNDA J; XU Y; WINTON MJ; TROJANOWSKI JQ; LEE VM

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

JOURNAL OF CLINICAL INVESTIGATION; Lugar: Ann Arbor, Michigan; Año: 2011 vol. 121 p. 726 - 738

IGAZ LM; KWONG LK; CHEN-PLOTKIN A; WINTON MJ; UNGER TL; XU Y; NEUMANN M; TROJANOWSKI JQ; LEE VM

Expression of TDP-43 C-terminal fragments in vitro recapitulates pathological features of TDP-43 proteinopathies

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2009 vol. 284 p. 8516 - 8524

GESER F; WINTON MJ; KWONG LK; XU Y; XIE SX; IGAZ LM; GARRUTO RM; PERL DP; GALASKO D; LEE VM; TROJANOWSKI JQ

Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam

ACTA NEUROPATHOLOGICA; Año: 2008 vol. 115 p. 133 - 145

WINTON MJ; IGAZ LM; WONG MM; KWONG LK; TROJANOWSKI JQ; LEE VM

Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2008 vol. 283 p. 13302 - 13309

IGAZ LM; KWONG LK; XU Y; TRUAX AC; URYU K; NEUMANN M; CLARK CM; ELMAN LB; MILLER BL; GROSSMAN M; MCCLUSKEY LF; TROJANOWSKI JQ; LEE VM

Enrichment of C-terminal Fragments in TDP-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

AMERICAN JOURNAL OF PATHOLOGY; Año: 2008 vol. 173 p. 182 - 194

BEKINSCHTEIN P; KATCHE C; SLIPCZUK LN; IGAZ LM; CAMMAROTA M; IZQUIERDO I; MEDINA JH

mTOR signaling in the hippocampus is necessary for memory formation.

NEUROBIOLOGY OF LEARNING AND MEMORY; Año: 2007 vol. 87 p. 303 - 307

BEKINSCHTEIN P; CAMMAROTA M; IGAZ LM; BEVILAQUA LR; IZQUIERDO I; MEDINA JH

Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus

NEURON; Año: 2007 vol. 53 p. 261 - 277

NEUMANN M; IGAZ LM; KWONG LK; NAKASHIMA-YASUDA H; KOLB SJ; DREYFUSS G; KRETZSCHMAR HA; TROJANOWSKI JQ; LEE VM

Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.

ACTA NEUROPATHOLOGICA; Año: 2007 vol. 113 p. 543 - 548

IGAZ LM; WINOGRAD M; CAMMAROTA M; IZQUIERDO LA; ALONSO M; IZQUIERDO I; MEDINA JH

Early activation of extracellular signal-regulated kinase signaling pathway in the hippocampus is required for short-term memory formation of a fear-motivated learning.

CELLULAR AND MOLECULAR NEUROBIOLOGY.; Año: 2006 vol. 26 p. 989 - 1002

IGAZ LM; BEKINSCHTEIN P; VIANNA MM; IZQUIERDO I; MEDINA JH

Gene expression during memory formation.

NEUROTOXICITY RESEARCH; Año: 2004 vol. 6 p. 189 - 204

IGAZ LM; BEKINSCHTEIN P; IZQUIERDO I; MEDINA JH

One-trial aversive learning induces late changes in hippocampal CaMKIIalpha, Homer 1a, Syntaxin 1a and ERK2 protein levels.

MOLECULAR BRAIN RESEARCH; Año: 2004 vol. 132 p. 1 - 12

VIANNA MR; IGAZ LM; COITINHO AS; MEDINA JH; IZQUIERDO I

Memory extinction requires gene expression in rat hippocampus.

NEUROBIOLOGY OF LEARNING AND MEMORY; Año: 2003 vol. 79 p. 199 - 203

IGAZ LM; REFOJO D; COSTAS MA; HOLSBOER F; ARZT E

CRE-mediated transcriptional activation is involved in cAMP protection of T-cell receptor-induced apoptosis but not in cAMP potentiation of glucocorticoid-mediated programmed cell death.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH; Año: 2002 vol. 1542 p. 139 - 148

IZQUIERDO I; VIANNA MR; IZQUIERDO LA; BARROS DM; SZAPIRO G; COITINHO AS; IGAZ LM; CAMMAROTA M; BEVILAQUA LR; MEDINA JH

Memory retrieval and its lasting consequences.

NEUROTOXICITY RESEARCH; Año: 2002 vol. 4 p. 573 - 593

IGAZ LM; VIANNA MR; MEDINA JH; IZQUIERDO I

Two time periods of hippocampal mRNA synthesis are required for memory consolidation of fear-motivated learning.

JOURNAL OF NEUROSCIENCE; Año: 2002 vol. 22 p. 6781 - 6789

ARZT E; KOVALOVSKY D; IGAZ LM; COSTAS M; PLAZAS P; REFOJO D; PÁEZ-PEREDA M; REUL JM; STALLA G; HOLSBOER F

Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES.; Año: 2000 vol. 917 p. 672 - 677

COSTAS MA; IGAZ LM; HOLSBOER F; ARZT E

Transrepression of NF-kappaB is not required for glucocorticoid-mediated protection of TNF-alpha-induced apoptosis on fibroblasts.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH; Año: 2000 vol. 1499 p. 122 - 129