NÚÑEZ, SOL YANEL; TROTTA, ALDANA; REGGE, MARÍA VICTORIA; AMARILLA, MARÍA SOFÍA; SECCHIARI, FLORENCIA; SIERRA, JESSICA MARIEL; SANTILLI, MARÍA CECILIA; GANTOV, MARIANA; ROVEGNO, AGUSTÍN; RICHARDS, NICOLÁS; AMERI, CARLOS; RÍOS PITA, HERNANDO; RICO, LUIS; MIEGGI, MAURO; VITAGLIANO, GONZALO; BLAS, LEANDRO; FRIEDRICH, ADRIÁN DAVID; DOMAICA, CAROLINA INÉS; FUERTES, MERCEDES BEATRIZ; ZWIRNER, NORBERTO WALTER

Tumor‐associated macrophages impair NK cell IFN‐γ production and contribute to tumor progression in clear cell renal cell carcinoma

EUROPEAN JOURNAL OF IMMUNOLOGY; Año: 2024 vol. 54

SECCHIARI, FLORENCIA; NUÑEZ, SOL YANEL; SIERRA, JESSICA MARIEL; ZIBLAT, ANDREA; REGGE, MARÍA VICTORIA; RAFFO IRAOLAGOITIA, XIMENA LUCÍA; ROVEGNO, AGUSTÍN; AMERI, CARLOS; SECIN, FERNANDO PABLO; RICHARDS, NICOLÁS; RÍOS PITA, HERNANDO; VITAGLIANO, GONZALO; RICO, LUIS; MIEGGI, MAURO; FRASCHERI, FLORENCIA; BONANNO, NICOLÁS; BLAS, LEANDRO; TROTTA, ALDANA; FRIEDRICH, ADRIÁN DAVID; FUERTES, MERCEDES BEATRIZ; DOMAICA, CAROLINA INÉS; ZWIRNER, NORBERTO WALTER

The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncology

OncoImmunology; Año: 2022 vol. 11

SIERRA, JESSICA M.; SECCHIARI, FLORENCIA; NUÑEZ, SOL Y.; IRAOLAGOITIA, XIMENA L. RAFFO; ZIBLAT, ANDREA; FRIEDRICH, ADRIÁN D.; REGGE, MARÍA V.; SANTILLI, M. CECILIA; TORRES, NICOLÁS I.; GANTOV, MARIANA; TROTTA, ALDANA; AMERI, CARLOS; VITAGLIANO, GONZALO; PITA, HERNANDO RÍOS; RICO, LUIS; ROVEGNO, AGUSTÍN; RICHARDS, NICOLÁS; DOMAICA, CAROLINA I.; ZWIRNER, NORBERTO W.; FUERTES, MERCEDES B.

Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8+ T Cell Proliferation

Frontiers in Immunology; Año: 2021 vol. 12

FUERTES, MERCEDES BEATRIZ; DOMAICA, CAROLINA INÉS; ZWIRNER, NORBERTO WALTER

Leveraging NKG2D Ligands in Immuno-Oncology

Frontiers in Immunology; Año: 2021 vol. 12

ZIBLAT, ANDREA; IRAOLAGOITIA, XIMENA LUCÍA RAFFO; NUÑEZ, SOL YANEL; TORRES, NICOLÁS IGNACIO; SECCHIARI, FLORENCIA; SIERRA, JESSICA MARIEL; SPALLANZANI, RAÚL GERMÁN; ROVEGNO, AGUSTÍN; SECIN, FERNANDO PABLO; FUERTES, MERCEDES BEATRIZ; DOMAICA, CAROLINA INÉS; ZWIRNER, NORBERTO WALTER

Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1

Frontiers in Immunology; Año: 2021 vol. 12

TORRES, NICOLAS; REGGE, MARÍA VICTORIA; SECCHIARI, FLORENCIA; FRIEDRICH, ADRIÁN DAVID; SPALLANZANI, RAÚL GERMÁN; RAFFO IRAOLAGOITIA, XIMENA LUCÍA; NÚÑEZ, SOL YANEL; SIERRA, JESSICA MARIEL; ZIBLAT, ANDREA; SANTILLI, MARÍA CECILIA; GILIO, NICOLÁS; ALMADA, EVANGELINA; LAUCHE, CONSTANZA; PARDO, ROMINA; DOMAICA, CAROLINA INÉS; FUERTES, MERCEDES BEATRIZ; MADAUSS, KEVIN PATRICK; HANCE, KENNETH W; GLOGER, ISRAEL S; ZYLBERMAN, VANESA; GOLDBAUM, FERNANDO ALBERTO; ZWIRNER, NORBERTO WALTER

Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein

Journal for ImmunoTherapy of Cancer; Año: 2020 vol. 8

ZWIRNER, NORBERTO W.; DOMAICA, CAROLINA I.; FUERTES, MERCEDES B.

Regulatory functions of NK cells during infections and cancer

JOURNAL OF LEUKOCYTE BIOLOGY; Año: 2020

NORBERTO WALTER ZWIRNER; MERCEDES BEATRIZ FUERTES; CAROLINA INES DOMAICA

LAS CÉLULAS LINFOIDES INNATAS. LOS NUEVOS ACTORES EN LA HOMEOSTASIS TISULAR Y LAS RESPUESTAS INFLAMATORIAS

MEDICINA (BUENOS AIRES); Año: 2019

ZIBLAT, ANDREA; NUÑEZ, SOL Y.; RAFFO IRAOLAGOITIA, XIMENA LUCÍA; SPALLANZANI, RAÚL GERMAN; TORRES, NICOLÁS I.; SIERRA, JESSICA M.; SECCHIARI, FLORENCIA; DOMAICA, CAROLINA I.; FUERTES, MERCEDES B.; ZWIRNER, NORBERTO W.

Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56bright Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation

Frontiers in Immunology; Año: 2018 vol. 8

NUÑEZ, SOL Y.; ZIBLAT, ANDREA; SECCHIARI, FLORENCIA; TORRES, NICOLÁS I.; SIERRA, JESSICA M.; RAFFO IRAOLAGOITIA, XIMENA L.; ARAYA, ROMINA E.; DOMAICA, CAROLINA I.; FUERTES, MERCEDES B.; ZWIRNER, NORBERTO W.

Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j

JOURNAL OF IMMUNOLOGY; Año: 2018 vol. 200 p. 1008 - 1015

XIMENA LUCIA RAFFO IRAOLAGOITIA; RAUL GERMÁN SPALLANZANI; NICOLAS IGNACIO TORRES; ROMINA ELIZABETH ARAYA; ANDREA ZIBLAT; CAROLINA INES DOMAICA; JESSICA MARIEL SIERRA; SOL YANEL NUÑEZ; FLORENCIA SECCHIARI; THOMAS F. GAJEWSKI; NORBERTO WALTER ZWIRNER; MERCEDES BEATRIZ FUERTES

NK cells restrain spontaneous anti-tumor CD8+ T cell priming through PD-1/PD-L1 interactions with dendritic cells

JOURNAL OF IMMUNOLOGY; Lugar: Bethesda; Año: 2016 vol. 197 p. 953 - 961

ANDREA ZIBLAT; CAROLINA INES DOMAICA; RAUL GERMÁN SPALLANZANI; XIMENA RAFFO IRAOLAGOITIA; LUCAS EZEQUIEL ROSSI; DAMIAN AVILA; NICOLAS IGNACIO TORRES; MERCEDES BEATRIZ FUERTES; NORBERTO WALTER ZWIRNER

IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness

EUROPEAN JOURNAL OF IMMUNOLOGY; Lugar: Weinheim; Año: 2015 vol. 45 p. 192 - 202

RAUL GERMÁN SPALLANZANI; NICOLAS IGNACIO TORRES; DAMIAN AVILA; ANDREA ZIBLAT; XIMENA LUCIA RAFFO IRAOLAGOITIA; LUCAS EZEQUIEL ROSSI; CAROLINA INES DOMAICA; MERCEDES BEATRIZ FUERTES; GABRIEL ADRIAN RABINOVICH; NORBERTO WALTER ZWIRNER

Regulatory Dendritic Cells Restrain NK Cell IFN-gamma Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors

JOURNAL OF IMMUNOLOGY; Lugar: Bethesda; Año: 2015 vol. 195 p. 2141 - 2148

ROBBERT SPAAPEN; MICHAEL M.Y. LEUNG; MERCEDES BEATRIZ FUERTES; JUSTIN KLINE; LONG ZHANG; YAN ZHENG; YANG-YIN FU; XIXI LUO; KENNETH S. COHEN; THOMAS F. GAJEWSKI

Therapeutic Activity of High-Dose Intratumoral IFN-β Requires Direct Effect on the Tumor Vasculature

JOURNAL OF IMMUNOLOGY; Lugar: Bethesda; Año: 2014 vol. 193 p. 4254 - 4260

SENG-RYONG WOO; MERCEDES BEATRIZ FUERTES; LETICIA CORRALES; STEFANI SPRANGER; MICHAEL J. FURDYNA; MICHAEL M.Y. LEUNG; RYAN DUGGAN; YING WANG; GLEN N. BARBER; KATHERINE A. FITZGERALD; MARIA-LUISA ALEGRE; THOMAS F. GAJEWSKI

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

IMMUNITY; Lugar: United States; Año: 2014 vol. 41 p. 830 - 842

MERCEDES BEATRIZ FUERTES; SENG-RYONG WOO; BYRON BURNETT; YANG-XIN FU; THOMAS F. GAJEWSKI

Type I interferon response and innate immune sensing of cancer.

TRENDS IN IMMUNOLOGY; Lugar: Amsterdam; Año: 2013 p. 67 - 73

YESSICA L. ALLEGRETTI; CONSTANZA BONDAR; LUCIANA GUZMAN; EDUARDO CUETO RUA; NESTOR CHOPITA; MERCEDES FUERTES; NORBERTO W. ZWIRNER; FERNANDO G. CHIRDO

Broad MICA/B Expression in the Small Bowel Mucosa: A Link between Cellular Stress and Celiac Disease

PLOS ONE; Lugar: San Francisco; Año: 2013 vol. 8 p. 73658 - 73658

RAUL GERMÁN SPALLANZANI; TOMAS DALOTTO MORENO; XIMENA RAFFO IRAOLAGOITIA; ANDREA ZIBLAT; CAROLINA INES DOMAICA; DAMIAN AVILA; LUCAS EZEQUIEL ROSSI; MERCEDES BEATRIZ FUERTES; MARÍA AGUSTINA BATTISTONE; GABRIEL ADRIAN RABINOVICH; MARIANA SALATINO; NOR

Expansion of CD11b+Ly6G +Ly6C int cells driven by medroxyprogesterone acetate in mice bearing breast tumors restrains NK cell effector functions

CANCER IMMUNOLOGY IMMUNOTHERAPY; Lugar: Berlin; Año: 2013 vol. 62 p. 1781 - 1795

LUCAS EZEQUIEL ROSSI; DAMIAN AVILA; RAUL GERMÁN SPALLANZANI; ANDREA ZIBLAT; MERCEDES BEATRIZ FUERTES; LARA LAPYKYJ; DIEGO O. CROCI; GABRIEL ADRIAN RABINOVICH; CAROLINA INES DOMAICA; NORBERTO WALTER ZWIRNER

Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression.

JOURNAL OF LEUKOCYTE BIOLOGY; Lugar: Bethesda; Año: 2012 vol. 91 p. 321 - 331

THOMAS F. GAJEWSKI; MERCEDES BEATRIZ FUERTES; SENG-RYONG WOO

Innate immune sensing of cancer: clues from an identified role for type I IFNs.

CANCER IMMUNOLOGY IMMUNOTHERAPY; Lugar: Berlin; Año: 2012 vol. 61 p. 1343 - 1347

CAROLINA INES DOMAICA; MERCEDES BEATRIZ FUERTES; IGNACIO URIARTE; MARÍA VICTORIA GIRART; JESSICA SARDAÑONS; DORINA ILEANA COMAS; DANIELA DI GIOVANNI; MARÍA ISABEL GAILLARD; LILIANA BEZRODNIK; NORBERTO WALTER ZWIRNER

Human Natural Killer Cell Maturation Defect Supports In Vivo CD56(bright) to CD56(dim) Lineage Development

PLOS ONE; Lugar: San Francisco; Año: 2012 vol. 7 p. 51677 - 51678

THOMAS F. GAJEWSKI ; MERCEDES FUERTES; ROBBERT SPAAPEN; YAN ZHENG; JUSTIN KLINE

Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment

CURRENT OPINION IN IMMUNOLOGY; Lugar: Amsterdam; Año: 2011 vol. 23 p. 286 - 292

MERCEDES BEATRIZ FUERTES; AALOK K. KACHA; JUSTIN KLINE; SENG-RYONG WOO; DAVID M. KRANZ; KENNETH M. MURPHY; THOMAS F. GAJEWSKI

Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells

JOURNAL OF EXPERIMENTAL MEDICINE; Año: 2011 vol. 208 p. 2005 - 2016

MARTA ALICIA TOSCANO; LEONARDO CAMPAGNA; LUCIANA LORENA MOLINERO; JUAN PABLO CERLIANI; DIEGO O. CROCI; JUAN MARTÍN ILARREGUI; MERCEDES BEATRIZ FUERTES; IGNACIO NOJEK; JUAN PABLO FEDEDA; NORBERTO WALTER ZWIRNER; MONICA A. COSTAS; GABRIEL ADRIAN RABINOVICH

Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1

MOLECULAR IMMUNOLOGY; Año: 2011 p. 1940 - 1949

MERCEDES BEATRIZ FUERTES; LUCAS EZEQUIEL ROSSI; CARLOS M. PERALTA; HUGO N. CABRERA; MIGUEL ALLEVATO; NORBERTO WALTER ZWIRNER

Premalignant quiescent melanocytic nevi do not express the MHC class I chain-related protein A

MEDICINA (BUENOS AIRES); Año: 2011 vol. 71 p. 357 - 360

CAROLINA INES DOMAICA; MERCEDES BEATRIZ FUERTES; LUCAS EZEQUIEL ROSSI; MARIA VICTORIA GIRART; DAMIAN AVILA; GABRIEL ADRIAN RABINOVICH; NORBERTO WALTER ZWIRNER

Tumour-experienced T cells promote NK cell activity through trogocytosis of NKG2D and NKp46 ligands

EMBO JOURNAL; Año: 2009 vol. 10 p. 908 - 915

MERCEDES BEATRIZ FUERTES; MARÍA VICTORIA GIRART; LUCIANA LORENA MOLINERO; CAROLINA INES DOMAICA; LUCAS EZEQUIEL ROSSI; MARCELA BARRIO; JOSE MORDOH; GABRIEL ADRIAN RABINOVICH; NORBERTO WALTER ZWIRNER

Intracellular retention of the NKG2D ligand MHC class I chain-related gene A in human melanomas confers immune privilege and prevents NK cell-mediated cytotoxicity

JOURNAL OF IMMUNOLOGY; Año: 2008 vol. 180 p. 4606 - 4614

NORBERTO WALTER ZWIRNER; MERCEDES BEATRIZ FUERTES; MARÍA VICTORIA GIRART; CAROLINA INES DOMAICA; LUCAS EZEQUIEL ROSSI

Cytokine-driven regulation of NK cell functions in tumor immunity: Role of the MICA-NKG2D system

Cytokine and Growth factor reviews; Lugar: Nueva York; Año: 2007 vol. 18 p. 159 - 170

MARÍA VICTORIA GIRART; MERCEDES BEATRIZ FUERTES; CAROLINA INES DOMAICA; LUCAS EZEQUIEL ROSSI; NORBERTO WALTER ZWIRNER

Engagement of TLR3, TLR7 and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with bsuboptimal doses of IL-12

JOURNAL OF IMMUNOLOGY; Lugar: Bethesda; Año: 2007 vol. 179 p. 3472 - 3479

LUCIANA LORENA MOLINERO; CAROLINA INES DOMAICA; MERCEDES BEATRIZ FUERTES; MARíA VICTORIA GIRART; LUCAS EZEQUIEL ROSSI; NORBERTO WALTER ZWIRNER

Intracellular Expression of MICA in Activated CD4 T Lymphocytes and Protection from NK Cell-Mediated MICA-Dependent Cytotoxicity

HUMAN IMMUNOLOGY; Lugar: New York; Año: 2006 vol. 67 p. 170 - 182

NORBERTO WALTER ZWIRNER; MERCEDES BEATRIZ FUERTES; MARÍA VICTORIA GIRART; CAROLINA INES DOMAICA; LUCAS EZEQUIEL ROSSI

Immunobiology of the human MHC class I chain-related gene A (MICA): from transplantation immunology to tumor immune escape

Inmunologia; Lugar: Barcelona; Año: 2006 vol. 25 p. 25 - 38

LUCIANA LORENA MOLINERO; MERCEDES BEATRIZ FUERTES; MARÍA VICTORIA GIRART; LEONARDO FAINBOIM; GABRIEL ADRIÁN RABINOVICH; MÓNICA COSTAS; NORBERTO WALTER ZWIRNER

NF-kB-regulated expression of the MHC class I related chain A gene (MICA) on activated T lymphocytes

JOURNAL OF IMMUNOLOGY; Lugar: Bethesda; Año: 2004 vol. 173 p. 5583 - 5590

MERCEDES BEATRIZ FUERTES; LUCIANA LORENA MOLINERO; MARTA ALICIA TOSCANO; JUAN MARTÍN ILARREGUI; NATALIA RUBINSTEIN; LEONARDO FAINBOIM; NORBERTO WALTER ZWIRNER; GABRIEL ADRIAN RABINOVICH

Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase

MOLECULAR AND CELLULAR BIOCHEMISTRY; Lugar: Dordrecht ; Año: 2004 vol. 267 p. 177 - 185

LUCIANA LORENA MOLINERO; MERCEDES BEATRIZ FUERTES; LEONARDO FAINBOIM; GABRIEL ADRIAN RABINOVICH; NORBERTO WALTER ZWIRNER

Up-regulated expression of MICA on activated T lymphocytes involves Lck and Fyn kinases, and signaling trough MEK1/ERK, p38 MAP kinase and calcineurin

JOURNAL OF LEUKOCYTE BIOLOGY; Lugar: Bethesda; Año: 2003 vol. 73 p. 815 - 822

LUCIANA LORENA MOLINERO; MERCEDES BEATRIZ FUERTES; GABRIEL ADRIAN RABINOVICH; LEONARDO FAINBOIM; NORBERTO WALTER ZWIRNER

Activation-induced expression of MICA on T lymphocytes involves engagement of CD3 and CD28

JOURNAL OF LEUKOCYTE BIOLOGY; Lugar: Bethesda; Año: 2002 vol. 71 p. 791 - 797