ANTINORI, M.B.; SYCHANTHA, D.; KOTEVA, K.; SUAREZ, I.P.; PERALTA, M.D.; WRIGHT, G.E.*; LLARRULL, L.I.*

The histidine kinase VraS orchestrates the cell-wall stress response in Staphylococcus aureus via its direct interaction with glycopeptides and β-lactams

bioRxiv; Lugar: Cold Spring Harbor, NY; Año: 2025

DI GREGORIO, SABRINA NOELIA ; WELTMAN, GABRIELA; FABBRI, CAROLINA; FERNÁNDEZ, SILVINA; ZÁRATE, SOLEDAD ; SMAYEVSKY, JORGELINA ; POWER, PABLO ; CAMPOS, JOSEFINA ; LLARRULL, LETICIA IRENE; MOLLERACH, MARTA

Genetic and phenotypic changes related to the development of mec-independent oxacillin nonsusceptibility in ST8 Staphylococcus aureus recovered after antibiotic therapy in a patient with bacteremia

Antibiotics; Lugar: Basilea; Año: 2024 vol. 13 p. 554 - 571

BELLUZO, BRUNO S.; ABRIATA, LUCIANO A.; GIANNINI, ESTEFANÍA; MIHOVILCEVIC, DAMILA; DAL PERARO, MATTEO; LLARRULL, LETICIA I.

An experiment-informed signal transduction model for the role of the Staphylococcus aureus MecR1 protein in β-lactam resistance

Scientific Reports; Año: 2019 vol. 9 p. 19558 - 19572

PALACIOS, ANTONELA R.; MOJICA, MARÍA F.; GIANNINI, ESTEFANÍA; TARACILA, MAGDALENA A.; BETHEL, CHRISTOPHER R.; ALZARI, PEDRO M.; OTERO, LISANDRO H.; KLINKE, SEBASTIÁN; LLARRULL, LETICIA I.; BONOMO, ROBERT A.; VILA, ALEJANDRO J.

THE REACTION MECHANISM OF METALLO-β-LACTAMASES IS TUNED BY THE CONFORMATION OF AN ACTIVE SITE MOBILE LOOP

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Lugar: Washington; Año: 2018

LISA, M.N.; PALACIOS, A.R.; AITHA, M. ; GONZÁLEZ, M.M.; MORENO, D.M. ; CROWDER, M.W.; BONOMO, R.A.; SPENCER, J.; TIERNEY, D.L.; LLARRULL, L.I.*; VILA, A.J.*

A General Reaction Mechanism for Carbapenem Hydrolysis by Mono- and Binuclear Metallo-beta-lactamases

NATURE COMMUNICATIONS; Año: 2017

HINCHLIFFE, P.; GONZALEZ, M.; MOJICA, M.F.; GONZÁLEZ, J. M.; CASTILLO, V.; SAIZ, C.; KOSMOPOULOU, M.; TOOKE, C.L.; LLARRULL, L.I.; MAHLER, S.G.; BONOMO, R.A.; VILA, A.J.*; SPENCER, J.*

Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2016 vol. 113 p. 3745 - 3754

BOUDREAU, M.A.; FISHOVITZ, J.; LLARRULL, L.I.; XIAO, Q.; MOBASHERY, S.*

Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules

ACS Infectious Diseases; Lugar: Washington DC, USA; Año: 2015 vol. 1 p. 454 - 459

MOJICA, M.F.; MAHLER, S.G.; BETHEL, C.R.; TARACILA, M.A.; KOSMOPOULOU, M.; PAPP-WALLACE, K.M.; LLARRULL, L.I.; WILSON, B.M.; MARSHALL, S.H.; WALLACE, C.J.; VILLEGAS, M.V.; HARRIS, M.E.; VILA, A.J.; SPENCER, J.; BONOMO, R.A.

Exploring the Role of Residue 228 for Substrate and Inhibitor Recognition by VIM Metallo-beta-Lactamases

BIOCHEMISTRY; Lugar: Washington; Año: 2015 vol. 54 p. 3183 - 3196

GONZALEZ, M.M.; KOSMOPOULOU, M.; MOJICA, M.F.; CASTILLO, V.; HINCHLIFFE, P; PETTINATI, I; BREM, J; SCHOFIELD, C; MAHLER, S.G.; BONOMO, R.A.; LLARRULL L. I.; SPENCER, J.; VILA A. J.

Bisthiazolidines: a substrate-mimicking scaffold as an inhibitor of the NDM-1 carbapenemase

ACS Infectious Diseases; Año: 2015 vol. 1 p. 544 - 554

MEINI, M.R.*; LLARRULL, L.I.*; VILA, A.J.*

Overcoming differences: the catalytic mechanism of metallo-beta-lactamases

FEBS LETTERS; Lugar: Amsterdam; Año: 2015 vol. 589 p. 3419 - 3432

MEINI, M.R.*; LLARRULL, L.I.*; VILA, A.J.*

Evolution of Metallo-beta-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution.

Antibiotics; Lugar: Basilea; Año: 2014 vol. 3 p. 285 - 316

O'DANIEL, P.I.; PENG, Z.; PI, H.; TESTERO, S.A.; DING, D.; SPINK, E.; LEEMANS, E.; BOUDREAU, M.A.; YAMAGUCHI, T.; SCHROEDER, V.A.; WOLTER, W.R.; LLARRULL, L.I.; SONG, W.; LASTOCHKIN, E.; KUMARASIRI, M.; ANTUNES, N.T.; ESPAHBODI, M.; LICHTENWALTER, K.; SUCKOW, M.A.; VAKULENKO, S.; MOBASHERY, S.; CHANG, M.

Discovery of a New Class of Non-beta-lactam Inhibitors of Penicillin- Binding Proteins with Gram-Positive Antibacterial Activity

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington; Año: 2014 vol. 136 p. 3664 - 3672

BLAZQUEZ, B.*; LLARRULL, L.I.*; LUQUE-ORTEGA, J.R.; ALFONSO, C.; BOGGESS, B.; MOBASHERY, S.

Regulation of the Expression of the beta-Lactam Antibiotic-Resistance Determinants in Methicillin-Resistant Staphylococcus aureus (MRSA)

BIOCHEMISTRY; Lugar: Washington; Año: 2014 vol. 53 p. 1548 - 1550

LEE, M.; HESEK, D.; LLARRULL, L.I.; LASTOCHKIN, E.; PI, E.; BOGGESS, B.; MOBASHERY, S.

Reactions of All E. coli Lytic transglycosylaseswith Bacterial Cell Wall

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington; Año: 2013 vol. 135 p. 3311 - 3314

OTERO, L.H.; ROJAS-ALTUVE, A.; LLARRULL, L.I.; CARRASCO-LÓPEZ, C.; KUMARASIRI, M.; LASTOCHKIN, E.; FISHOVITZ, J.; DAWLEY, M.; HESEK, D.; LEE, M.; JOHNSON, J.W.; FISHER, J.F.; CHANG, M.; MOBASHERY, S.; HERMOSO, J.A.

How Allosteric Control of Staphylococcus aureus Penicillin-Binding Protein 2a Enables Methicillin-Resistance and Physiological Function

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2013 vol. 110 p. 16808 - 16813

LLARRULL, L.I.; MOBASHERY, S.

Dissection of Events in the Resistance to beta-Lactam Antibiotics Mediated by the Protein BlaR1 from Staphylococcus aureus.

BIOCHEMISTRY; Lugar: Washington; Año: 2012 vol. 51 p. 4642 - 4649

BREECE, R.M.; LLARRULL, L.I.; TIONI, M.F.; VILA, A.J.; TIERNEY, D.

X-Ray Absorption Spectroscopy of Metal Site Speciation in the Metallo-beta-Lactamase BcII from Bacillus cereus.

JOURNAL OF INORGANIC BIOCHEMISTRY; Lugar: NEW YORK; Año: 2012 vol. 111 p. 182 - 186

YAMAGUCHI, T.; BLAZQUEZ, B.; HESEK, D.; LEE, M.; LLARRULL, L.I.; BOGGESS, B.; OLIVER, A.; FISHER, J.F.; MOBASHERY, S.

Inhibitors for Bacterial Cell-Wall Recycling

ACS Medicinal Chemistry Letters; Lugar: Washington; Año: 2012 vol. 3 p. 238 - 242

KUMARASIRI, M.; LLARRULL, L.I.; BORBULEVYCH, O.; FISHOVITZ, J; LASTOCHKIN, E.; BAKER, B. M.; MOBASHERY, S.

An Amino-Acid Position at the Crossroads of Evolution of Protein Function: Antibiotic-Sensor Domain of the BlaR1 Protein from Staphylococcus aureus vs. Class D â ?Lactamases

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: BETHESDA; Año: 2012 vol. 287 p. 8232 - 8241

ARTOLA-RECOLONS, C; CARRASCO-LÓPEZ, C.; LLARRULL, L.I.; KUMARASIRI, M.; LASTOCHKIN, E.; MARTÍNEZ DE ILARDUYA, I.; MEINDL, K.; USÓN, I.; MOBASHERY, S.; HERMOSO, J.A.

High-Resolution Crystal Structure of an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase (MltE) from Escherichia coli.

BIOCHEMISTRY; Lugar: Washington; Año: 2011 vol. 50 p. 2384 - 2386

TESTERO, S.A.*; LEE, M.*; STARAN, R.T.; ESPAHBODI, M.; LLARRULL, L.I.; TOTH, M.; MOBASHERY, S.; CHANG, M.

Sulfonate-Containing Thiiranes as Selective Gelatinase Inhibitors

ACS Medicinal Chemistry Letters; Lugar: Washington; Año: 2011 vol. 2 p. 177 - 181

TESTERO, S.A.; LLARRULL, L.I.; FISHER, J.F.; CHANG, M.; MOBASHERY, S.

Exploring the Functional Space of Thiiranes as Gelatinase Inhibitors using Click Chemistry.

ARKIVOC - ONLINE JOURNAL OF ORGANIC CHEMISTRY; Lugar: GAINESVILLE; Año: 2011 vol. VII p. 221 - 236

ARTOLA-RECOLONS, C; LLARRULL, L.I.; LASTOCHKIN, E.; MOBASHERY, S.; HERMOSO, J.A.

Crystallization and Preliminary X-Ray Diffraction of Lytic Transglycosylase MltE from Escherichi coli

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS; Lugar: MALDEN; Año: 2011 vol. F67 p. 161 - 163

LLARRULL, L.I.; TOTH, M.; CHAMPION, M. M.; MOBASHERY, S.

Activation of BlaR1 Protein of Methicillin-Resistant Staphylococcus aureus, Its Proteolytic Processing and Recovery from Induction of Resistance.

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: BETHESDA; Año: 2011 vol. 286 p. 38148 - 38158

BORBULEVYCH, O.; KUMARASIRI, M.; WILSON, B.; LLARRULL, L.I.; LEE, M.; HESEK, D.; SHI, Q.; PENG, J.; BAKER, B. M.; MOBASHERY, S.

Lysine N-Decarboxylation Switch and Activation of the beta-Lactam-Sensor Domain of BlaR1 of Methicillin-Resistant Staphylococcus aureus.

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: BETHESDA; Año: 2011 vol. 286 p. 31466 - 31472

LLARRULL, L.I.; PROROK, M.; MOBASHERY, S.

Binding of the Gene Repressor BlaI to the bla Operon in Methicillin-Resistant Staphylococcus aureus

BIOCHEMISTRY; Lugar: Washington; Año: 2010 vol. 49 p. 7975 - 7977

LLARRULL, L.I.; TESTERO, S.A.; FISHER, J.F.; MOBASHERY, S.

The future of the beta-lactams

CURRENT OPINION IN MICROBIOLOGY; Lugar: Londres; Año: 2010 vol. 13 p. 551 - 557

LLARRULL, L.I.; FISHER, J.F.; MOBASHERY, S.

Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Lugar: Washington; Año: 2009 vol. 53 p. 4051 - 4063

FORBES, C.; SHI, Q.; FISHER, J.F.; LEE, M.; HESEK, D.; LLARRULL, L.I.; TOTH, M.; GOSSING, M.; FRIDMAN, R.; MOBASHERY, S.

Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases

CHEMICAL BIOLOGY & DRUG DESIGN; Lugar: MALDEN; Año: 2009 vol. 74 p. 527 - 534

LLARRULL, L.I.; TIONI, M.F.; VILA, A.J.

Metal Content and Localization during Turnover in B. cereus Metallo-beta-Lactamase

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington; Año: 2008 vol. 130 p. 15842 - 15851

ABRIATA, L.A.; GONZÁLEZ, L.; LLARRULL, L.I.; TOMATIS, P.E.; MYERS, W.; COSTELLO, A.; TIERNEY, D.; VILA, A.J.

Engineered mononuclear variants in Bacillus cereus metallo-beta-lactamase BcII are inactive

BIOCHEMISTRY; Lugar: Washington; Año: 2008 vol. 47 p. 8590 - 8599

TIONI, M.F.; LLARRULL, L.I.; POEYLAUT-PALENA, A. A; MARTÍ, M. A.; SAGGU, M.; PERIYANNAN, G. R.; MATA, E. G.; BENNETT, B.; MURGIDA, D. H; VILA, A.J.

Trapping and Characterization of a Reaction Intermediate in Carbapenem Hydrolysis by B. cereus Metallo-beta-lactamase

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington DC; Año: 2008 vol. 130 p. 15852 - 15863

LLARRULL, L.I.*; TIONI, M.F.*; KOWALSKI, J.M.; BENNETT, B.; VILA, A.J.

Evidence for a dinuclear active site in the metallo-beta-lactamase BcII with substoichiometric Co(II): A new model for metal uptake

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: BETHESDA; Año: 2007 vol. 282 p. 30586 - 30595

LLARRULL, L.I.; FABIANE, S.M.; KOWALSKI, J.M.; BENNETT, B.; SUTTON, B.J.; VILA, A.J.

Asp120 locates Zn2 for optimal metallo-beta-lactamase activity

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: BETHESDA; Año: 2007 vol. 282 p. 18276 - 18285

SCHUJMAN, G.E.; GUERIN, M.; BUSCHIAZZO, A.; SCHAEFFER, F.; LLARRULL, L.I.; REH, G.; VILA, A.J.; ALZARI, P.M.; DE MENDOZA, D.

Structural basis of lipid biosynthesis regulation in Gram-positive bacteria

EMBO JOURNAL; Lugar: NEW YORK; Año: 2006 vol. 25 p. 4074 - 4083

DAL PERARO, M.; LLARRULL, L.I.; ROTHLISBERGER, U.; VILA, A.J.; CARLONI, P.

Water-assisted reaction mechanism of monozinc beta-lactamases

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington; Año: 2004 vol. 126 p. 12661 - 12668