LEDESMA-BAZAN, SABRINA; CASCARDO, FLORENCIA; BIZZOTTO, JUAN; OLSZEVICKI, SANTIAGO; VAZQUEZ, ELBA; GUERON, GERALDINE; COTIGNOLA, JAVIER

Predicting prostate cancer progression with a Multi-lncRNA expression-based risk score and nomogram integrating ISUP grading

Non-coding RNA Research; Año: 2024

ANSELMINO, NICOLAS; LABANCA, ESTEFANIA; SHEPHERD, PETER D.A.; DONG, JIABIN; YANG, JUN; SONG, XIAOFEI; NANDAKUMAR, SUBHIKSHA; KUNDRA, RITIKA; LEE, CINDY J.; SCHULTZ, NIKOLAUS; ZHANG, JIANHUA; ARAUJO, JOHN C.; APARICIO, ANA M.; SUBUDHI, SUMIT K.; CORN, PAUL G.; PISTERS, LOUIS L.; WARD, JOHN F.; DAVIS, JOHN W.; VAZQUEZ, ELBA S.; GUERON, GERALDINE; LOGOTHETIS, CHRISTOPHER J.; FUTREAL, ANDREW; TRONCOSO, PATRICIA; CHEN, YU; NAVONE, NORA M.

Integrative molecular analyses of the MD Anderson prostate cancer patient-derived xenograft (MDA PCa PDX) series

CLINICAL CANCER RESEARCH; Año: 2024

TORO, AYELEN; RUIZ, MARÍA SOL; LAGE-VICKERS, SOFIA; SANCHIS, PABLO; SABATER, AGUSTINA; PASCUAL, GASTON; SENIUK, ROCIO; CASCARDO, FLORENCIA; LEDESMA-BAZAN, SABRINA; VILICICH, FELIPE; VAZQUEZ, ELBA; GUERON, GERALDINE

A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?

Antioxidants; Año: 2022 vol. 11

LAGE-VICKERS, SOFIA; SANCHIS, PABLO; BIZZOTTO, JUAN; TORO, AYELEN; SABATER, AGUSTINA; LAVIGNOLLE, ROSARIO; ANSELMINO, NICOLAS; LABANCA, ESTEFANIA; PAEZ, ALEJANDRA; NAVONE, NORA; VALACCO, MARIA P.; COTIGNOLA, JAVIER; VAZQUEZ, ELBA; GUERON, GERALDINE

Exploiting Interdata Relationships in Prostate Cancer Proteomes: Clinical Significance of HO-1 Interactors

Antioxidants; Año: 2022 vol. 11

SANCHIS, PABLO; ANSELMINO, NICOLAS; LAGE-VICKERS, SOFIA; SABATER, AGUSTINA; LAVIGNOLLE, ROSARIO; LABANCA, ESTEFANIA; SHEPHERD, PETER D. A.; BIZZOTTO, JUAN; TORO, AYELEN; MITROFANOVA, ANTONINA; VALACCO, MARIA PIA; NAVONE, NORA; VAZQUEZ, ELBA; COTIGNOLA, JAVIER; GUERON, GERALDINE

Bone Progenitors Pull the Strings on the Early Metabolic Rewiring Occurring in Prostate Cancer Cells

Cancers; Año: 2022 vol. 14

TORO, AYELEN; LAGE-VICKERS, SOFIA; BIZZOTTO, JUAN; VILICICH, FELIPE; SABATER, AGUSTINA; PASCUAL, GASTON; LEDESMA-BAZAN, SABRINA; SANCHIS, PABLO; RUIZ, MARIA SOL; AREVALO, ANA PAULA; PORFIDO, JORGE L.; ABBATE, MERCEDES; SENIUK, ROCIO; LABANCA, ESTEFANIA; ANSELMINO, NICOLAS; NAVONE, NORA M.; ALONSO, DANIEL F.; VAZQUEZ, ELBA; CRISPO, MARTINA; COTIGNOLA, JAVIER; GUERON, GERALDINE

Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection

Viruses; Año: 2022 vol. 14

SOFIA LAGE VICKERS; JUAN BIZZOTTO; PIA VALACCO; PABLO SANCHIS; SERGIO NEMIROVSKY; ESTEFANIA LABANCA; CARLOS SCORTICATI; OSVALDO MAZZA ; ANTONINA MITROFANOVA; NORA NAVONE; VAZQUEZ ELBA; JAVIER COTIGNOLA; GERALDINE GUERON

The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer

Communications Biology; Año: 2021

CASCARDO, FLORENCIA; ANSELMINO, NICOLÁS; PAEZ, ALEJANDRA; LABANCA, ESTEFANIA; SANCHIS, PABLO; ANTICO ARICUCH, VALERIA; NAVONE, NORA; GUERON, GERALDINE; VAZQUEZ, ELBA; COTIGNOLA, JAVIER

HO-1 Modulates Aerobic Glycolysis through LDH in Prostate Cancer Cells

Antioxidants; Año: 2021

ESTEFANIA LABANCA; JUAN BIZZOTTO; PABLO SANCHIS; ANSELMINO NICOLAS; JUN YANG; PETER SHEPERD; ALEJANDRA PAEZ; ANTICO ARICUCH, VALERIA; SOFIA LAGE VICKERS; ANH HOANG; XIMING TANG; MARIA GABRIELA RASO; MARK TITUS; ELENI EFSTATHIOU; JAVIER COTIGNOLA; JOHN ARAUJO; CHRISTOPHER LOGOTHETIS; ELBA VAZQUEZ; NAVONE NORA; GERALDINE GUERON

Prostate cancer castrate resistant progression usage of non-canonical androgen receptor signaling and ketone body fuel

ONCOGENE; Lugar: Londres; Año: 2021

ARÁOZ, BEATRIZ; KARAKAYA, EMINE; GONZÁLEZ WUSENER, ANA; DETSCH, RAINER; BIZZOTTO, JUAN; GUERON, GERALDINE; BOCCACCINI, ALDO R.; HERMIDA, ÉLIDA B.

3D printed poly(hydroxybutyrate-co-hydroxyvalerate)—45S5 bioactive glass composite resorbable scaffolds suitable for bone regeneration

JOURNAL OF MATERIALS RESEARCH; Año: 2021

SEGATORI, VALERIA INÉS; GARONA, JUAN; CALIGIURI, LORENA GRISEL; BIZZOTTO, JUAN; LAVIGNOLLE, ROSARIO; TORO, AYELÉN; SANCHIS, PABLO; SPITZER, EDUARDO; KROLEWIECKI, ALEJANDRO; GUERON, GERALDINE; ALONSO, DANIEL FERNANDO

Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients

Viruses; Año: 2021 vol. 13

SANCHIS, PABLO; LAVIGNOLLE, ROSARIO; ABBATE, MERCEDES; LAGE-VICKERS, SOFÍA; VAZQUEZ, ELBA; COTIGNOLA, JAVIER; BIZZOTTO, JUAN; GUERON, GERALDINE

Analysis workflow of publicly available RNA-sequencing datasets

STAR Protocols; Año: 2021 vol. 2

LABANCA ESTEFANIA; JUN YANG; PETER D A SHEPHERD; XINHAI WAN ; MICHAEL W STARBUCK;  LEAH D GUERRA; NICOLAS ANSELMINO; JUAN A BIZZOTTO; JIABIN DONG; ARUL M CHINNAIYAN ; MURALI K RAVOORI; VIKAS KUNDRA; BRADLEY M BROOM; PAUL G CORN; PATRICIA TRONCOSO; GUERON GERALDINE; CHRISTOPHER LOGOTHETIS; NAVONE NORA

Fibroblast Growth Factor Receptor 1 Drives the Metastatic Progression of Prostate Cancer

European Urology Oncology; Lugar: Amsterdam; Año: 2021

SENRA, DANIELA; PÁEZ, ALEJANDRA; GUERON, GERALDINE; BRUNO, LUCIANA; GUISONI, NARA

Following the footprints of variability during filopodial growth

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS; Lugar: Berlin; Año: 2020

ORTIZ, EMILIANO G; SANCHIS, PABLO A; BIZZOTTO, JUAN; LAGE VICKERS, SOFIA; LABANCA, ESTEFANIA; NAVONE, NORA; COTIGNOLA, JAVIER; VAZQUEZ, ELBA; GUERON, GERALDINE

Myxovirus resistance protein 1 (MX1), a novel HO-1 interactor, tilts the balance of endoplasmic reticulum stress towards pro-death events in prostate cancer

Biomolecules; Año: 2020

ANSELMINO, NICOLÁS; BIZZOTTO, JUAN; SANCHIS, PABLO A; LAGE VICKERS, SOFIA; ORTIZ, EMILIANO G; VALACCO, MARIA PIA; PAEZ, ALEJANDRA; LABANCA, ESTEFANIA; MEISS, ROBERTO P.; NAVONE, NORA; COTIGNOLA, JAVIER; VAZQUEZ, ELBA S; GUERON, GERALDINE

HO-1 Interactors Involved in the Colonization of the Bone Niche: Role of ANXA2 in Prostate Cancer Progression

Biomolecules; Año: 2020

BIZZOTTO, JUAN; SANCHIS, PABLO; ABBATE, MERCEDES; LAGE-VICKERS, SOFÍA; LAVIGNOLLE, ROSARIO; TORO, AYELÉN; OLSZEVICKI, SANTIAGO; SABATER, AGUSTINA; CASCARDO, FLORENCIA; VAZQUEZ, ELBA; COTIGNOLA, JAVIER; GUERON, GERALDINE

SARS-CoV-2 Infection Boosts MX1 Antiviral Effector in COVID-19 Patients

iScience; Año: 2020 vol. 23

ANSELMINO, NICOLÁS; MICHAEL STARBUCK; LABANCA, ESTEFANIA; COTIGNOLA, JAVIER; NAVONE, NORA; GUERON, GERALDINE; ZENCLUSSEN, ANA; VAZQUEZ, ELBA S

HMOX1 IS A PIVOTAL MODULATOR OF BONE TURN OVER AND REMODELING. MOLECULAR IMPLICATIONS FOR PROSTATE CANCER BONE METASTASIS.

ANTIOXIDANTS & REDOX SIGNALING; Lugar: New York; Año: 2020

DALTON, GUILLERMO NICOLÁS; MASILLO, CINTIA; SCALISE, GEORGINA DANIELA; DUCA, ROCÍO; PORRETTI, LUCIANA; FARRÉ, PAULA LUCÍA; GARDNER, KEVIN; PÁEZ, ALEJANDRA; GUERON, GERALDINE; DE LUCA, PAOLA; DE SIERVI, ADRIANA

CTBP1 depletion on prostate tumors deregulates miRNA/mRNA expression and impairs cancer progression in metabolic syndrome mice.

Cell Death & Disease; Año: 2019

RAMAKRISHNAN, SWATHI; GRANGER, VICTORIA; RAK, MONICA; HU, QIANG; ATTWOOD, KRISTOPHER; AQUILA, LANNI; KRISHNAN, NITHYA; OSIECKI, RAFAL; AZABDAFTARI, GISSOU; GURU, KHURSHID; CHATTA, GURKAMAL; GUERON, GERALDINE; MCNALLY, LACEY; OHM, JOYCE; WANG, JIANMIN; WOLOSZYNSKA-READ, ANNA

Inhibition of EZH2 induces NK cell-mediated differentiation and death in invasive bladder cancer.

CELL DEATH AND DIFFERENTIATION; Lugar: Londres; Año: 2019

LEONARDI, DAIANA B.; ANSELMINO, NICOLÁS; BRANDANI, JAVIER N.; JAWORSKI, FELIPE M.; PAEZ, ALEJANDRA; MAZAIRA, GISELA; MEISS, ROBERTO P.; NUÑEZ, MYRIAM; NEMIROVSKY, SERGIO I.; GUIDICE, GIMENA; GALIGNIANA, MARIO; PECCI, ADALÍ; GUERON, GERALDINE; VAZQUEZ, ELBA S.; COTIGNOLA, JAVIER H.

Heme Oxygenase 1 Impairs Glucocorticoid Receptor Activity in Prostate Cancer

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Lugar: Basel; Año: 2019

GUERON, GERALDINE; ANSELMINO, NICOLÁS; CHIARELLA, PAULA; ORTIZ, EMILIANO G.; LAGE VICKERS, SOFIA; PAEZ, ALEJANDRA V.; GIUDICE, JIMENA; CONTIN, MARIO D.; LEONARDI, DAIANA; JAWORSKI, FELIPE; MANZANO, VERÓNICA; STRAZZA, ARIEL; MONTAGNA, DANIELA R.; LABANCA, ESTEFANIA; COTIGNOLA, JAVIER; D´ACCORSO, NORMA; WOLOSZYNSKA-READ, ANNA; NAVONE, NORA; MEISS, ROBERTO P.; RUGGIERO, RAÚL; VAZQUEZ, ELBA

Game-changing restraint of Ros-damaged phenylalanine, upon tumor metastasis

Cell Death & Disease; Año: 2018 vol. 9

VALERIA ANTICO; GUERON GERALDINE; COTIGNOLA JAVIER; ELBA VAZQUEZ

Altered Signaling Pathways in Prostate Cancer Drive Metabolic Fate

INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH; Año: 2017 vol. 6

PAEZ, ALEJANDRA; VAZQUEZ, ELBA; GUERON, GERALDINE

Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells

Cell Death Discovery; Año: 2017 vol. 3

RAMAKRISHNAN, SWATHI; HU, QIANG; KRISHNAN, NITHYA; WANG, DAN; SMIT, EVELYN; GRANGER, VICTORIA; RAK, MONIKA; ATTWOOD, KRISTOPHER; JOHNSON, CANDACE; MORRISON, CARL; PILI, ROBERTO; CHATTA, GURKAMAL; GURU, KHURSHID; GUERON, GERALDINE; MCNALLY, LACEY; WANG, JIANMIN; WOLOSZYNSKA-READ, ANNA

Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer

Cell Death & Disease; Lugar: Londres; Año: 2017 vol. 8

JAWORSKI, FELIPE M.; GENTILINI, LUCAS D.; GUERON, GERALDINE; MEISS, ROBERTO P.; ORTIZ, EMILIANO G.; BERGUER, PAULA M.; AHMED, ASIF; NAVONE, NORA; RABINOVICH, GABRIEL A.; COMPAGNO, DANIEL; LADERACH, DIEGO J.; VAZQUEZ, ELBA S.

In Vivo Hemin Conditioning Targets the Vascular and Immunologic Compartments and Restrains Prostate Tumor Development

CLINICAL CANCER RESEARCH; Año: 2017 vol. 23 p. 5135 - 5148

DAIANA LEONARDI; ABBATE MERCEDES; RICCHERI MARIA; MYRIAM NUÑEZ; GRACIELA ALFONSO; GERALDINE GUERON; ADRIANA DE SIERVI; ELBA VAZQUEZ; COTIGNOLA JAVIER

Improving risk strati cation of patients with childhood acute lymphoblastic leukemia: Glutathione-S-Transferases polymorphisms are associated with increased risk of relapse

Oncotarget; Año: 2017

PAEZ, ALEJANDRA V; PALLAVICINI, CARLA; SCHUSTER, FEDERICO; VALACCO, MARIA PIA; GIUDICE, JIMENA; ORTIZ, EMILIANO G; ANSELMINO, NICOLÁS; LABANCA, ESTEFANIA; BINAGHI, MARIA; SALIERNO, MARCELO; MARTÍ, MARCELO A; COTIGNOLA, JAVIER H; WOLOSZYNSKA-READ, ANNA; BRUNO, LUCIANA; LEVI, VALERIA; NAVONE, NORA; VAZQUEZ, ELBA S; GUERON, GERALDINE

Heme oxygenase-1 in the forefront of a multi-molecular network that governs cell–cell contacts and filopodia-induced zippering in prostate cancer

Cell Death and Disease; Año: 2016 vol. 7

ESTEFANIA LABANCA; PAOLA DE LUCA; GERALDINE GUERON; ALEJANDRA PAEZ; MOIOLA CRISTIAN; CINTIA MASILLO; JULIANA PORRETI; JIMENA GIUDICE; ZALAZAR FLORENCIA; NAVONE NORA; ELBA VAZQUEZ; ADRIANA DE SIERVI

Association of HO-1 and BRCA1 Is Critical for the Maintenance of Cellular Homeostasis in Prostate Cancer

MOLECULAR CANCER RESEARCH; Lugar: Philadelphia; Año: 2015 vol. 13 p. 1455 - 1464

GUERON GERALDINE; GIUDICE JIMENA; VALACCO PIA; PAEZ ALEJANDRA; ELGUERO BELEN; TOSCANI, MARTIN; JAWORSKI FELIPE MARTÍN; COLLUCCIO-LESKOW FEDERICO; COTIGNOLA JAVIER; MARTI MARCELO; BINAGHI MARIA; NAVONE NORA; VAZQUEZ ELBA

HEME-OXYGENASE - 1 IMPLICATIONS IN CELL MORPHOLOGY AND THE ADHESIVE BEHAVIOR OF PROSTATE CANCER CELLS.

Oncotarget; Año: 2014

GUERON GERALDINE; AVANZO ROMINA; SCHUSTER FEDERICO; CARABELOS MARIA NOELIA; VAZQUEZ ELBA; FASCIO MIRTA; D'ACCORSO NORMA

Differential effect of heterocyclic D-ribofuranoside derivatives on human prostate cancer cell viability and cell cycle progression

BIOMEDICINE & PHARMACOTHERAPY = BIOMEDECINE & PHARMACOTHERAPIE.; Lugar: Atlanta; Año: 2014

SHAKIL AHMAD; PETER W. HEWETT; TAKESHI FUJISAWA; SAMIR SISSAOUI; MENG CAI; GERALDINE GUERON; MELISSA CUDMORE; FARAZ AHMED; MICHAEL K. K. WONG; BARBARA WEGIEL; LEO E. OTTERBEIN; LIBOR VÍTEK; WENDA RAMMA; KEQING WANG; ASIF AHMED

Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation

JOURNAL OF THROMBOSIS AND HAEMOSTASIS; Lugar: Londres; Año: 2014

ELGUERO BELEN; GUERON GERALDINE; GIUDICE JIMENA; TOSCANI, MARTIN; DE LUCA PAOLA; ZALAZAR FLORENCIA; COLLUCCIO-LESKOW FEDERICO; MEISS ROBERTO; NAVONE NORA; ADRIANA DE SIERVI; VAZQUEZ ELBA

UNVEILING THE ASSOCIATION OF STAT3 AND HO-1 IN PROSTATE CANCER: ROLE BEYOND HEME DEGRADATION

NEOPLASIA; Lugar: Michigan; Año: 2012 vol. 14 p. 1043 - 1056

GUERON GERALDINE; DE SIERVI ADRIANA; VAZQUEZ ELBA

Key Questions in Metastasis: New Insights in Molecular Pathways and Therapeutic Implications.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY; Año: 2011 vol. 12 p. 1 - 14

DE LUCA PAOLA; VAZQUEZ ELBA; MOIOLA CRISTIAN; ZALAZAR FLORENCIA; COTIGNOLA JAVIER; GUERON GERALDINE; GARDNER KEVIN; DE SIERVI ADRIANA

BRCA1 Loss Induces GADD153-Mediated Doxorubicin Resistance in Prostate Cancer

MOLECULAR CANCER RESEARCH; Lugar: Philadelphia; Año: 2011 vol. 9 p. 1078 - 1090

FERRANDO MERCEDES; GUERON GERALDINE; ELGUERO BELEN; GIUDICE JIMENA; SALLES ANGELES; COLLUCCIO-LESKOW FEDERICO; JARES-ERIJMAN E; COLOMBO LUCAS; MEISS ROBERTO; NAVONE NORA; VAZQUEZ ELBA

HEME OXYGENASE 1 (HO-1) CHALLENGES THE ANGIOGENIC SWITCH IN PROSTATE CANCER

ANGIOGENESIS; Año: 2011 vol. 14 p. 467 - 479

GUERON GERALDINE; DE SIERVI ADRIANA; VAZQUEZ ELBA

ADVANCED PROSTATE CANCER: REINFORCING THE STRINGS BETWEEN INFLAMMATION AND THE METASTATIC BEHAVIOUR

PROSTATE CANCER AND PROSTATIC DISEASES; Año: 2011

DE SIERVI ADRIANA; DE LUCA PAOLA; MOIOLA CRISTIAN; GUERON GERALDINE; TONGBAI R; CHANDRAMOULI GV; HAGGERTY C; DZEKUNOVA I; PETERSEN D; KAWASAKI E; KIL WJ; CAMPHAUSEN K; LONGO D; GARDNER K

Identification of new Rel/NFkappaB regulatory networks by focused genome location analysis.

Cell Cycle; Lugar: Austin, TX, USA; Año: 2009 vol. 8 p. 2093 - 2100

GUERON GERALDINE; DE SIERVI ADRIANA; FERRANDO MERCEDES; SALIERNO MARCELO; DE LUCA PAOLA; ELGUERO BELEN; MEISS ROBERTO; NAVONE NORA; VAZQUEZ ELBA

Critical role of endogenous heme oxygenase 1 (HO-1) as a tuner of the invasive potential of prostate cancer cells

Molecular Cancer Research; Lugar: Philadelphia, USA; Año: 2009 p. 1745 - 1755

GUERON GERALDINE; DE SIERVI ADRIANA; FERRANDO MERCEDES; SALIERNO MARCELO; DE LUCA PAOLA; ELGUERO BELEN; MEISS ROBERTO; NAVONE NORA; VAZQUEZ ELBA

Critical role of endogenous heme oxygenase 1 (HO-1) as a tuner of the invasive potential of prostate cancer cells

MOLECULAR CANCER RESEARCH; Lugar: Philadelphia, USA; Año: 2009 p. 1745 - 1755

DE SIERVI ADRIANA; DE LUCA PAOLA; MOIOLA CRISTIAN; GUERON GERALDINE; TONGBAI R; CHANDRAMOULI GV; HAGGERTY C; DZEKUNOVA I; PETERSEN D; KAWASAKI E; KIL WJ; CAMPHAUSEN K; LONGO D; GARDNER K

Identification of new Rel/NFkappaB regulatory networks by focused genome location analysis.

CELL CYCLE; Lugar: Austin, TX, USA; Año: 2009 vol. 8 p. 2093 - 2100

YUN GEW; JUNG S. BYUNW; PAOLA DE LUCA; GERALDINE GUERON; IDALIA M. YABE; SARA G. SADIQ-ALIA; WILLIAM D. FIGGO; JESSE QUINTERO; CYNTHIA M. HAGGERTY; QUENTIN Q. LIA; ADRIANA DE SIERVID; KEVIN GARDNERF

Combinatorial Antileukemic Disruption of Oxidative Homeostasis and Mitochondrial Stability by the Redox Reactive Thalidomide 2-(2,4-Difluoro-phenyl)-4,5,6,7- tetrafluoro-1H-isoindole-1,3(2H)-dione (CPS49) and Flavopiridol

Molecular Pharmacology; Año: 2008 vol. 74 p. 872 - 883

YUN GEW; JUNG S. BYUNW; PAOLA DE LUCA; GERALDINE GUERON; IDALIA M. YABE; SARA G. SADIQ-ALIA; WILLIAM D. FIGGO; JESSE QUINTERO; CYNTHIA M. HAGGERTY; QUENTIN Q. LIA; ADRIANA DE SIERVID; KEVIN GARDNERF

Combinatorial Antileukemic Disruption of Oxidative Homeostasis and Mitochondrial Stability by the Redox Reactive Thalidomide 2-(2,4-Difluoro-phenyl)-4,5,6,7- tetrafluoro-1H-isoindole-1,3(2H)-dione (CPS49) and Flavopiridol

MOLECULAR PHARMACOLOGY; Año: 2008 vol. 74 p. 872 - 883