RICARDI, LAURA LIS; ZECCHINATI, FELIPE (COMPARTE PRIMER AUTORÍA); PERDOMO, VIRGINIA GABRIELA; BASIGLIO, CECILIA LORENA; GARCÍA, FABIANA; ARANA, MAITE ROCÍO; VILLANUEVA, SILVINA STELLA MARIS

Oxidative stress promotes post-translational down-regulation of MRP2 in Caco-2 cells: Involvement of proteasomal degradation and toxicological implications

FOOD AND CHEMICAL TOXICOLOGY; Año: 2025 vol. 201

BARRANCO, MARÍA MANUELA; ZECCHINATI, FELIPE; PERDOMO, VIRGINIA GABRIELA; HABIB, MARTÍN JOSÉ; RICO, MARÍA JOSÉ; ROZADOS, VIVIANA ROSA; SALAZAR, MARIO; FUSINI, MATÍAS EZEQUIEL; SCHAROVSKY, OLGA GRACIELA; VILLANUEVA, SILVINA STELLA MARIS; MAINETTI, LEANDRO ERNESTO; GARCÍA, FABIANA

Intestinal ABC transporters: Influence on the metronomic cyclophosphamide-induced toxic effect in an obese mouse mammary cancer model

TOXICOLOGY AND APPLIED PHARMACOLOGY; Año: 2024 vol. 492

BARRANCO, M. M.; PERDOMO VG; ZECCHINATI, F.; MANARIN R; MASSUH G; SIGAL N.; VIGNADUZZO S; MOTTINO AD; VILLANUEVA SSM; GARCÍA, F.

Downregulation of intestinal multidrug resistance transporter 1 in obese mice: Effect on its barrier function and role of TNF-α receptor 1 signaling

Nutrition; Año: 2023 vol. 111

ZECCHINATI, FELIPE; BARRANCO, MARIA MANUELA; TOCCHETTI, GUILLERMO NICOLÁS; DOMINGUEZ, CAMILA; ARANA, MAITE ROCÍO; PERDOMO, VIRGINIA GABRIELA; MOTTINO, ALDO DOMINGO; GARCÍA, FABIANA; VILLANUEVA, SILVINA STELLA MARIS

Multidrug resistance-associated protein 2 is negatively regulated by oxidative stress in rat intestine via a posttranslational mechanism. Impact on its membrane barrier function

TOXICOLOGY; Lugar: Amsterdam; Año: 2021

VILLANUEVA, S. S. M.; PERDOMO VG; GARCÍA F

Función de la barrera intestinal. Implicancia en la enfermedad celíaca.

Revista Científica de la Facultad de Ciencias Médicas de la UNR; Lugar: Rosario; Año: 2021

ARANA, MAITE ROCÍO; DOMINGUEZ, CAMILA JULIANA; ZECCHINATI, FELIPE; TOCCHETTI, GUILLERMO NICOLÁS; MOTTINO, ALDO DOMINGO; MARIS VILLANUEVA, SILVINA STELLA

Role of interleukin 1 beta in the regulation of rat intestinal Multidrug resistance-associated protein 2 under conditions of experimental endotoxemia

TOXICOLOGY; Año: 2020

TOCCHETTI, GUILLERMO N.; DOMÍNGUEZ, CAMILA J.; ZECCHINATI, FELIPE; ARANA, MAITE R.; RIGALLI, JUAN P.; RUIZ, MARÍA L.; VILLANUEVA, SILVINA S. M.; MOTTINO, ALDO D.

Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon‐like peptide‐2‐mediated mechanism

ACTA PHYSIOLOGICA; Año: 2020

SEMENIUK, M.; CERÉ, L. I.; CIRIACI, N.; BUCCI-MUÑOZ, M.; VILLANUEVA, S. S. M.; MOTTINO, A. D.; CATANIA, V. A.; RIGALLI, J. P.; RUIZ, MARÍA LAURA

Regulation of hepatic P-gp expression and activity by genistein in rats

ARCHIVES OF TOXICOLOGY.; Año: 2020

PAINEFILÚ, JULIO C.; PASCUAL, MARIANO M.; BIECZYNSKI, FLAVIA; LASPOUMADERES, CECILIA; GONZÁLEZ, CAROLINA; VILLANUEVA, SILVINA S.M.; LUQUET, CARLOS M.

Ex vivo and in vivo effects of arsenite on GST and ABCC2 activity and expression in the middle intestine of the rainbow trout Oncorhynchus mykiss

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. TOXICOLOGY & PHARMACOLOGY; Año: 2019 vol. 225

VILLANUEVA, SILVINA; ZHANG, WEI; ZECCHINATI, FELIPE; MOTINO, ALDO; VORE, MARY

ABC transporters in extrahepatic tissues: Pharmacological regulation in heart and intestine

CURRENT MEDICINAL CHEMISTRY.; Año: 2019 vol. 25

ZECCHINATI, FELIPE; BARRANCO, MARIA MANUELA; ARANA, MAITE ROCÍO; TOCCHETTI, GUILLERMO NICOLÁS; DOMÍNGUEZ, CAMILA JULIANA; PERDOMO, VIRGINIA GABRIELA; RUIZ, MARÍA LAURA; MOTTINO, ALDO DOMINGO; GARCÍA, FABIANA; VILLANUEVA, SILVINA STELLA MARIS

Reversion of down-regulation of intestinal multidrug resistance-associated protein 2 in fructose-fed rats by geraniol and vitamin C: Potential role of inflammatory response and oxidative stress

JOURNAL OF NUTRITIONAL BIOCHEMISTRY; Año: 2019 vol. 68 p. 7 - 15

TOCCHETTI, GUILLERMO NICOLÁS; DOMÍNGUEZ, CAMILA JULIANA; ZECCHINATI, FELIPE; ARANA, MAITE ROCÍO; RUIZ, MARÍA LAURA; VILLANUEVA, SILVINA STELLA MARIS; WEISS, JOHANNA; MOTTINO, ALDO DOMINGO; RIGALLI, JUAN PABLO

Biphasic modulation of cAMP levels by the contraceptive nomegestrol acetate. Impact on P-glycoprotein expression and activity in hepatic cells.

BIOCHEMICAL PHARMACOLOGY; Año: 2018

TOCCHETTI, GUILLERMO NICOLÁS; DOMÍNGUEZ, CAMILA JULIANA; ZECCHINATI, FELIPE; ARANA, MAITE ROCÍO; RUIZ, MARÍA LAURA; VILLANUEVA, SILVINA STELLA MARIS; MOTTINO, ALDO DOMINGO; WEISS, JOHANNA; RIGALLI, JUAN PABLO

Inhibition of multidrug resistance-associated protein 2 (MRP2) activity by the contraceptive nomegestrol acetate in HepG2 and Caco-2 cells

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES; Año: 2018 vol. 122 p. 205 - 213

TOCCHETTI, GUILLERMO NICOLÁS; ARIAS, AGOSTINA; ARANA, MAITE ROCÍO; RIGALLI, JUAN PABLO; DOMÍNGUEZ, CAMILA JULIANA; ZECCHINATI, FELIPE; RUIZ, MARÍA LAURA; VILLANUEVA, SILVINA STELLA MARIS; MOTTINO, ALDO DOMINGO

Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17β-d-glucuronide in rat intestine and Caco-2 cells

ARCHIVES OF TOXICOLOGY.; Año: 2018 p. 1 - 12

ARANA, MAITE ROCÍO; TOCCHETTI, GUILLERMO NICOLÁS; ZECCHINATI, FELIPE; LONDERO, ANA SOFÍA; DOMINGUEZ, CAMILA; PERDOMO, VIRGINIA; RIGALLI, JUAN PABLO; VILLANUEVA, SILVINA STELLA MARIS; MOTTINO, ALDO DOMINGO

Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats

TOXICOLOGY; Año: 2017 vol. 390 p. 22 - 31

LONDERO AS; ARANA MR; PERDOMO VG; TOCCHETTI GN; ZECCHINATI F; GHANEM CI; RUIZ ML; RIGALLI JP; MOTTINO AD; FABIANA GARCIA; VILLANUEVA SS

Intestinal multidrug resistance-associated protein 2 is down-regulated in fructose-fed rats

JOURNAL OF NUTRITIONAL BIOCHEMISTRY; Lugar: Amsterdam; Año: 2017

TOCCHETTI GN; RIGALLI JP; ARANA MR; VILLANUEVA SSM; MOTTINO AD

Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics.

TOXICOLOGY AND APPLIED PHARMACOLOGY; Lugar: Amsterdam; Año: 2016

MAITE R. ARANA; GUILLERMO N. TOCCHETTI; JUAN P. RIGALLI; ALDO D. MOTTINO; SILVINA S. M. VILLANUEVA

Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine. Impact on its function as membrane barrier

PHARMACOLOGICAL RESEARCH; Lugar: Amsterdam; Año: 2016

RIGALLI JP; TOCCHETTI GN; ARANA MR; VILLANUEVA SSM; CATANIA VA; THEILE D; RUIZ ML; WEISS J

The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters

CANCER LETTERS; Lugar: Amsterdam; Año: 2016

BIECZYNSKI F; TORRES W; PAINEFILU J; CASTRO J; BIANCHI V; FRONTERA J; PAZ D; GONZÁLEZ C; MARTÍN A; VILLANUEVA S; LUQUET CM

Alterations in the intestine of Patagonian silverside (Odontesthes hatcheri) exposed to microcystin-LR: Changes in the glycosylation pattern of the intestinal wall and inhibition of multidrug resistance proteins efflux activity

AQUATIC TOXICOLOGY; Lugar: Amsterdam; Año: 2016

ARANA MR; TOCCHETTI GN; DOMIZI P; ARIAS A; RIGALLI JP; RUIZ ML; LUQUITA MG; BANCHIO C; MOTTINO AD; VILLANUEVA SSM

Coordinated Induction of GST and MRP2 by cAMP in Caco-2 Cells. Role of protein kinase A signaling pathway and toxicological relevance.

TOXICOLOGY AND APPLIED PHARMACOLOGY; Lugar: Amsterdam; Año: 2015

JUAN PABLO RIGALLI; NADIA CIRIACI; AGOSTINA ARIAS; MARÍA PAULA CEBALLOS; SILVINA VILLANUEVA; MARCELO LUQUITA; ALDO MOTTINO; CAROLINA GHANEM; VIVIANA CATANIA; MARIA LAURA RUIZ

Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line. Impact on Sorafenib cytotoxicity.

PLOS ONE; Lugar: San Francisco; Año: 2015

ARANA MR; ARIAS A; VILLANUEVA SILVINA; MOTTINO ALDO

Hepatic and intestinal biotransformation and transport of xenobiotics during pregnancy and lactation.

Physiological Mini Reviews; Lugar: La Plata; Año: 2014 vol. 7 p. 14 - 27

ARIAS A; RIGALLI JP; VILLANUEVA SS; RUIZ ML; LUQUITA MG; PERDOMO VG; VORE M; CATANIA VA; MOTTINO AD

Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity.

TOXICOLOGY; Lugar: Amsterdam; Año: 2014

BIECZYNSKI F; DE ANNA JS; PIREZ M; BRENA BM; VILLANUEVA SS; LUQUET CM

Cellular transport of microcystin-LR in rainbow trout (Oncorhynchus mykiss) across the intestinal wall: Possible involvement of multidrug resistance-associated proteins

AQUATIC TOXICOLOGY; Lugar: Amsterdam; Año: 2014 p. 97 - 106

MARÍA L. RUIZ; JUAN P. RIGALLI; AGOSTINA ARIAS; SILVINA S. M. VILLANUEVA; CLAUDIA BANCHIO; MARY VORE; ALDO D. MOTTINO; VIVIANA A. CATANIA

Estrogen receptor-alfa mediates human multidrug resistance associated protein 3 induction by 17alfa-ethynylestradiol. Role of activator protein-1.

BIOCHEMICAL PHARMACOLOGY; Lugar: Amsterdam; Año: 2013

VIRGINIA G. PERDOMO; RIGALLI JP; VILLANUEVA SSM; RUIZ ML; LUQUITA MG; ECHENIQUE CG; CATANIA VA

Modulation of biotransformation systems and ABC transporters by benznidazole in rats.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Lugar: Washington; Año: 2013

MARÍA L. RUIZ; JUAN P. RIGALLI; AGOSTINA ARIAS; SILVINA VILLANUEVA; CLAUDIA BANCHIO; MARY VORE; ALDO D. MOTTINO.; VIVIANA A. CATANIA

Induction of hepatic multidrug resistance associated protein 3 by ethynylestradiol is independent of cholestasis and mediated by estrogen receptor.

Drug Metabolism and Disposition; Lugar: Baltimore; Año: 2013 vol. 41 p. 275 - 280

JUAN P. RIGALLI; VIRGINIA G. PERDOMO; MARCELO G. LUQUITA; SILVINA S. M. VILLANUEVA; AGOSTINA ARIAS; DIRK THEILE; JOHANNA WEISS; ALDO D. MOTTINO.; MARÍA L. RUIZ; VIVIANA A. CATANIA

Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells. Involvement of pregnane X-receptor.

PLOS NEGLECTED TROPICAL DISEASES; Lugar: San Francisco; Año: 2012 vol. 6 p. 1 - 10

SILVINA S. M. VILLANUEVA; PERDOMO VG; MARÍA L. RUIZ; JUAN P. RIGALLI; AGOSTINA ARIAS; MARCELO G. LUQUITA; MARY VORE; VIVIANA A. CATANIA .; ALDO A. MOTTINO

Effect of Glucagon-Like Peptide 2 on Hepatic, Renal, and Intestinal Disposition of 1-Chloro-2,4-dinitrobenzene.

Drug Metabolism and Disposition; Lugar: Baltimore; Año: 2012 vol. 40 p. 1252 - 1258

RIGALLI JP; RUIZ ML; PERDOMO VG; VILLANUEVA SS; MOTTINO AD; CATANIA VA

Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells.

TOXICOLOGY; Año: 2011 vol. 285 p. 18 - 24

GHANEM CI; ARIAS A; NOVAK A; DELLICARPINI G; VILLANUEVA SS; BLAZQUEZ AG; MARIN JJ; MOTTINO AD; RUBIO MC

Acetaminophen-induced stimulation of MDR1 expression and activity in rat intestine and in LS 174T human intestinal cell line.

BIOCHEMICAL PHARMACOLOGY; Año: 2011 p. 244 - 250

VILLANUEVA SS; ARIAS A; RUIZ ML; RIGALLI JP; PELLEGRINO JM; VORE M; CATANIA VA; MOTTINO AD

Induction of intestinal multidrug resistance-associated protein 2 by glucagon-like Peptide 2 in the rat.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS; Año: 2010 p. 332 - 341

CAROLINA I. GHANEM; MARÍA L. RUIZ; SILVINA S.M. VILLANUEVA; MARCELO LUQUITA; SUSANA LLESUY; VIVIANA A. CATANIA; LAURA A. BENGOCHEA; ALDO D. MOTTINO

Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose

BIOCHEMICAL PHARMACOLOGY; Año: 2009 p. 1621 - 1628

AGOSTINA ARIAS; SILVINA S. M. VILLANUEVA; MARÍA L. RUIZ; MARCELO G. LUQUITA; LUIS M. VEGGI; JOSE M. PELLEGRINO; MARY VORE; VIVIANA A. CATANIA; AND ALDO D. MOTTINO

Regulation of expression and activity of rat intestinal Mrp2 by cholestatic estrogens

Drug Metabolism and Disposition; Año: 2009 vol. 37 p. 1277 - 1285

MARÍA L. RUIZ; SILVINA S.M. VILLANUEVA; MARCELO G. LUQUITA; JOSÉ M. PELLEGRINO; JUAN P. RIGALLI; AGOSTINA ARIAS; ENRIQUE J. SÁNCHEZ POZZI; ALDO D. MOTTINO; VIVIANA A. CATANIA

Induction of Multidrug resistance associated protein 2 (Mrp2) in rat intestine

EUROPEAN JOURNAL OF PHARMACOLOGY; Año: 2009 vol. 623 p. 103 - 106

VILLANUEVA SS; RUIZ ML; GHANEM CI; LUQUITA MG; CATANIA VA; MOTTINO AD

Hepatic synthesis and urinary elimination of acetaminophen glucuronide are exacerbated in bile duct-ligated rats.

Drug Metabolism and Disposition; Año: 2008 vol. 36 p. 475 - 480

RUIZ ML; VILLANUEVA SS; LUQUITA MG; IKUSHIRO S; MOTTINO AD; CATANIA VA

Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: involvement of up-regulation of multidrug resistance-associated protein 2.

Drug Metabolism and Disposition; Año: 2007 vol. 35 p. 2060 - 2066

SILVINA S. M. VILLANUEVA; MARÍA L. RUIZ; CAROL J. SOROKA; SHI-YING CAI; MARCELO G. LUQUITA; ADRIANA M. TORRES; ENRIQUE J. SÁNCHEZ POZZI; JOSÉ M. PELLEGRINO; JAMES L. BOYER; VIVIANA A. CATANIA; ALDO D. MOTTINO

"Hepatic and extrahepatic synthesis and disposition of dinitrophenyl-Sglutathione in bile duct-ligated rats"

Drug Metabolism and Disposition; Año: 2006 vol. 34 p. 1301 - 1309

MARÍA L. RUIZ; SILVINA S. M. VILLANUEVA; MARCELO G. LUQUITA; MARY VORE; ALDO D. MOTTINO; VIVIANA A. CATANIA

"Ethynylestradiol increases expression and activity of rat liver MRP3"

Drug Metabolism and Disposition; Año: 2006 vol. 34 p. 1030 - 1034

RUIZ ML; VILLANUEVA SS; LUQUITA MG; SANCHEZ-POZZI EJ; CROCENZI FA; PELLEGRINO JM; OCHOA JE; VORE M; MOTTINO AD; CATANIA VA.

"Mechanisms involved in spironolactone-induced choleresis in the rat. Role of multidrug resistance-associated protein 2"

BIOCHEMICAL PHARMACOLOGY; Año: 2005 vol. 69 p. 531 - 539

GHANEM CI; RUIZ ML; VILLANUEVA SS; LUQUITA MG; CATANIA VA; JONES B; BENGOCHEA LA; VORE M; MOTTINO AD

“Shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats”

The Journal of pharmacology and experimental therapeutics; Año: 2005 vol. 315 p. 987 - 995

SILVINA S.M. VILLANUEVA; MARÍA L. RUIZ; MARCELO G. LUQUITA; ENRIQUE J. SÁNCHEZ POZZI; VIVIANA A. CATANIA .; ALDO D. MOTTINO

“Involvement Of Mrp2 In Hepatic And Intestinal Disposition Of Dinitrophenyl-S-Glutathione In Partially Hepatectomized Rats".

JOURNAL OF TOXICOLOGICAL SCIENCES, THE; Lugar: Oxford, EEUU; Año: 2005 vol. 84 p. 4 - 11

CATANIA VA; SANCHEZ POZZI EJ; LUQUITA MG; RUIZ ML; VILLANUEVA SS; JONES B; MOTTINO AD

“Co-regulation of expression of phase II metabolizing enzymes and multidrug resistance-associated protein 2”

Annals of Hepatology; Año: 2004 vol. 3 p. 11 - 17

CAROLINA I. GHANEM; PAULA C. GÓMEZ; MARÍA C. ARANA; MARÍA PERASSOLO; MARÍA L. RUIZ; SILVINA S.M. VILLANUEVA; ELENA J. OCHOA; VIVIANA A. CATANIA; LAURA A. BENGOCHEA; ALDO D. MOTTINO

“Effect of acetaminophen on expression and activity of rat livermultidrug resistance-associated protein 2 and P-glycoprotein”

BIOCHEMICAL PHARMACOLOGY; Año: 2004 vol. 68 p. 791 - 798