GRANJA-GALEANO, GINA; DOMINGUEZ-RUBIO, ANA PAULA; ZAPPIA, C. DANIEL; WOLFSON, MANUEL; SANZ-BLASCO, SARA; AISEMBERG, JULIETA; ZORRILLA-ZUBILETE, MARIA; FERNANDEZ, NATALIA; FRANCHI, ANA; FITZSIMONS, CARLOS P.; MONCZOR, FEDERICO

CB1 receptor expression and signaling are required for dexamethasone-induced aversive memory consolidation

NEUROPHARMACOLOGY; Año: 2023 vol. 239

SAHORES, ANA; GONZÁLEZ, ANGELA RODRÍGUEZ; YANEFF, AGUSTÍN; MAY, MARÍA; GÓMEZ, NATALIA; MONCZOR, FEDERICO; FERNÁNDEZ, NATALIA; DAVIO, CARLOS; SHAYO, CARINA

Ceefourin-1, a MRP4/ABCC4 inhibitor, induces apoptosis in AML cells enhanced by histamine

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS; Año: 2023 vol. 1867

ECHEVERRIA E; RIPOLL S; FABIAN L; SHAYO C; MONCZOR F; FERNANDEZ NC

Novel inhibitors of phosphorylation independent activity of GRK2 modulate cAMP signaling

Pharmacology Research and Perspectives; Año: 2022

BURGHI V; ECHEVERRIA E; ZAPPIA CD; DIAZ NEBREDA A; RIPOLL S; GOMEZ N; SHAYO C; DAVIO C; MONCZOR F; FERNANDEZ N

Biased agonism at histamine H1 receptor: Desensitization, internalization and MAPK activation triggered by antihistamines.

EUROPEAN JOURNAL OF PHARMACOLOGY; Lugar: Amsterdam; Año: 2021

RODRÍGUEZ GONZÁLEZ, ANGELA; SAHORES, ANA; DÍAZ-NEBREDA, ANTONELA; YANEFF, AGUSTÍN; DI SIERVI, NICOLÁS; GÓMEZ, NATALIA; MONCZOR, FEDERICO; FERNÁNDEZ, NATALIA; DAVIO, CARLOS; SHAYO, CARINA

MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux

FEBS JOURNAL; Año: 2020

ECHEVERRÍA, EMILIANA; CABRERA, MAIA; BURGHI, VALERIA; SOSA, MÁXIMO; RIPOLL, SONIA; YANEFF, AGUSTÍN; MONCZOR, FEDERICO; DAVIO, CARLOS; SHAYO, CARINA; FERNÁNDEZ, NATALIA

The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

Frontiers in Pharmacology; Año: 2020 vol. 11

RODRÍGUEZ GONZÁLEZ A; SAHORES A; DÍAZ NEBREDA A; YANEFF A; DI SIERVI N; GÓMEZ N; MONCZOR F; FERNÁNDEZ N; DAVIO C; SHAYO C

Multidrug resistance protein 4 (MRP4/ABCC4) expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux

FEBS JOURNAL; Año: 2020

CAROZZO, ALEJANDRO; YANEFF, AGUSTÍN; GÓMEZ, NATALIA; DI SIERVI, NICOLÁS; SAHORES, ANA; DIEZ, FEDERICO; ATTORRESI, ALEJANDRA I.; RODRÍGUEZ-GONZÁLEZ, ÁNGELA; MONCZOR, FEDERICO; FERNÁNDEZ, NATALIA; ABBA, MARTÍN; SHAYO, CARINA; DAVIO, CARLOS

Identification of MRP4/ABCC4 as a Target for Reducing the Proliferation of Pancreatic Ductal Adenocarcinoma Cells by Modulating the cAMP Efflux

MOLECULAR PHARMACOLOGY; Año: 2019 vol. 96 p. 13 - 25

DÍAZ NEBREDA, ANTONELA; ZAPPIA, CARLOS DANIEL; RODRÍGUEZ GONZÁLEZ, ANGELA; SAHORES, ANA; SOSA, MÁXIMO; BURGHI, VALERIA; MONCZOR, FEDERICO; DAVIO, CARLOS; FERNÁNDEZ, NATALIA; SHAYO, CARINA

Involvement of histamine H 1 and H 2 receptor inverse agonists in receptor's crossregulation

EUROPEAN JOURNAL OF PHARMACOLOGY; Año: 2019 p. 42 - 52

BURGHI, VALERIA; ECHEVERRÍA, EMILIANA B.; SOSA, MÁXIMO H.; QUIROGA, DIEGO T.; MUÑOZ, MARINA C.; DAVIO, CARLOS; MONCZOR, FEDERICO; FERNÁNDEZ, NATALIA C.; DOMINICI, FERNANDO P.

Participation of gai-adenylate cyclase and ERK1/2 in mas receptor signaling pathways

Frontiers in Pharmacology; Año: 2019 vol. 10

ECHEVERRÍA, EMILIANA; RUEDA, ANA JULIA VELEZ; CABRERA, MAIA; JURITZ, EZEQUIEL; BURGHI, VALERIA; FABIÁN, LUCAS; DAVIO, CARLOS; MENNA, PABLO LORENZANO; FERNÁNDEZ, NATALIA CRISTINA

Identification of inhibitors of the RGS homology domain of GRK2 by docking-based virtual screening

LIFE SCIENCES; Lugar: Amsterdam; Año: 2019

ZAPPIA, CARLOS D.; SOTO, ARIADNA; GRANJA-GALEANO, GINA; FENOY, IGNACIO; FERNANDEZ, NATALIA; DAVIO, CARLOS A.; SHAYO, CARINA; FITZSIMONS, CARLOS P.; GOLDMAN, ALEJANDRA; MONCZOR, FEDERICO

Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model

Pharmacology Research & Perspectives; Año: 2019 vol. 7

CABRERA M; ECHEVERRIA E; REMES LENICOV F; CARDAMA G; GONZALES N; DAVIO C; FERNANDEZ N; LORENZANO-MENNA P

Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines.

Oncotarget; Lugar: Buffalo; Año: 2017 vol. 8 p. 98509 - 98523

GRANJA-GALEANO, GINA; ZAPPIA, CARLOS DANIEL; FABIÁN, LUCAS; DAVIO, CARLOS; SHAYO, CARINA; FERNÁNDEZ, NATALIA; MONCZOR, FEDERICO

Effect of mutation of Phe 2436.44 of the histamine H2 receptor on cimetidine and ranitidine mechanism of action

BIOCHEMICAL PHARMACOLOGY; Año: 2017 vol. 146 p. 117 - 126

BURGHI, VALERIA; FERNÁNDEZ, NATALIA CRISTINA; GÁNDOLA, YAMILA BELÉN; PIAZZA, VERÓNICA GABRIELA; QUIROGA, DIEGO TOMÁS; MARIO, ÉRICA GUILHEN; BRAGA, JANAÍNA FELIX; BADER, MICHAEL; SANTOS, ROBSON AUGUSTO SOUZA; DOMINICI, FERNANDO PABLO; MUÑOZ, MARINA CECILIA

Validation of commercial Mas receptor antibodies for utilization in Western Blotting, immunofluorescence and immunohistochemistry studies

PLOS ONE; Año: 2017 vol. 12

ALONSO N; DIAZ NEBREDA A; MONCZOR F; GUTKIND JS; DAVIO C; FERNANDEZ N; SHAYO C

PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS; Lugar: Amsterdam; Año: 2016 vol. 1860 p. 1998 - 2007

MIRET N; PONTILLO C; VENTURA C; CAROZZO A; CHIAPPINI F; KLEIMAN D; FERNANDEZ N; COCCA C; RANDI A

Hexachlorobenzene modulates the crosstalk between the aryl hydrocarbon receptor and transforming growth factor-β1 signaling, enhancing human breast cancer cell migration and invasion.

TOXICOLOGY; Lugar: Amsterdam; Año: 2016

MONCZOR F; FERNANDEZ N

Current Knowledge and Perspectives on Histamine H1 and H2 Receptor Pharmacology: Functional Selectivity, Receptor Crosstalk, and Repositioning of Classic Histaminergic Ligands

MOLECULAR PHARMACOLOGY; Lugar: Baltimore; Año: 2016

ZAPPIA CD; GRANJA-GALEANO G; FERNANDEZ N; SHAYO C; DAVIO C; FITZSIMONS CP; MONCZOR F

Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways

Scientific Reports; Año: 2015 p. 17476 - 17480

CAROZZO A; DIEZ F; GOMEZ N; CABRERA M; SHAYO C; DAVIO C; FERNANDEZ N

Dual role of cAMP in the transcriptional regulation of multidrug resistance-associated protein 4 (MRP4) in pancreatic adenocarcinoma cell lines.

PLOS ONE; Lugar: San Francisco; Año: 2015

ALONSO N; ZAPPIA CD; CABRERA M; DAVIO C; SHAYO C; MONCZOR F; FERNANDEZ N

Physiological implications of biased signaling at histamine H2 receptors

Frontiers in pharmacology; Año: 2015

CABRERA M; GOMEZ N; REMES LENICOV F; ECHEVERRIA E; SHAYO C; MOGLIONI A; FERNANDEZ N; DAVIO C

G2/M cell cycle arrest and tumor selective apoptosis of a acute leukemia cell by a promising benzophenone thiosemicarbazone compound.

PLOS ONE; Lugar: San Francisco; Año: 2015 vol. 10 p. 1 - 21

ALONSO N; MONCZOR F; ECHEVERRIA E; DAVIO C; SHAYO C; FERNANDEZ N

Signal transduction mechanism of biased ligands at histamine H2 receptors.

BIOCHEMICAL JOURNAL; Lugar: Londres; Año: 2014 vol. 459 p. 117 - 126

PEREZ MJ; FERNANDEZ N; PASQUINI JM

Oligodendrocyte differentiation and signaling after transferrin internalization: a mechanism of action.

EXPERIMENTAL NEUROLOGY; Lugar: Amsterdam; Año: 2013 vol. 248 p. 262 - 274

ALONSO N; FERNANDEZ N; NOTCOVICH C; MONCZOR F; SIMAAN M; BALDI A; GUTKIND S; DAVIO C; SHAYO C

Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration.

MOLECULAR PHARMACOLOGY; Lugar: Baltimore; Año: 2013 vol. 83 p. 1087 - 1098

MONCZOR F; FERNANDEZ N; FITZSIMONS CP; SHAYO C; DAVIO C

Antihistaminergics and inverse agonism. Potential therapeutic applications

EUROPEAN JOURNAL OF PHARMACOLOGY; Lugar: Amsterdam; Año: 2013

VAZQUEZ RAMIRO; RIVEIRO ME; VERMEULEN M; ALONSO E; MONDILLO C; FACORRO G; PIEHL L; GOMEZ N; MOGLIONI A; FERNANDEZ N; BALDI A; SHAYO C; DAVIO C

Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: Key role of the ä-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action.

BIOORGANIC & MEDICINAL CHEMISTRY.; Lugar: Amsterdam; Año: 2012 vol. 20 p. 5537 - 5549

FERNANDEZ N; GOTTARDO F; ALONSO N; MONCZOR F; SHAYO C; DAVIO C

Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2011 vol. 286 p. 28697 - 28706

TUBIO MR; FERNANDEZ NC; FITZSIMONS CP; COPSEL S; SANTIAGO SD; SHAYO C; DAVIO C; MONCZOR F

The expression of a g protein coupled receptor (GPCR) leads to the attenuation of other GPCRs signaling. Experimental evidence for a spontaneous GPCR constitutive inactive form.

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2010

FERNANDEZ N; MONCZOR F; BALDI A; DAVIO C; SHAYO C

Histamine H2 receptor trafficking. Role of arrestin, dynamin and clathrin in H2r internalization.

MOLECULAR PHARMACOLOGY; Año: 2008 vol. 74 p. 1109 - 1118

NATALIA FERNANDEZ; FEDERICO MONCZOR; MARIA R TUBIO; CARINA SHAYO; CARLOS DAVIO

Regulatory mechanisms underlying GKR2 levels in U937 cells. Evidence for GRK3 involvement.

BIOCHEMICAL PHARMACOLOGY; Año: 2007 vol. 73 p. 1758 - 1767

MONCZOR F; FERNANDEZ N; RIVEIRO ME; MLADOVAN A; BALDI A; SHAYO C; DAVIO C

Histamine H2 receptor overexpression induces U937 cell differentiation despite triggered mechanisms to attenuate cAMP signalling.

BIOCHEMICAL PHARMACOLOGY; Año: 2006 vol. 71 p. 1219 - 1228

SHAYO, C.; LEGNAZZI, B. L.; MONCZOR, F.; FERNANDEZ, N.; RIVEIRO, M. E.; BALDI, A.; DAVIO, C.

The time-course of cyclic AMP signaling is critical for leukemia U-937 cell differentiation

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Año: 2004 vol. 314 p. 798 - 804

EUGENIA RIVEIRO, M; SHAYO, C.; MONCZOR, F.; FERNANDEZ, N.; BALDI, A.; DE KIMPE, N.; ROSSI, J.; DEBENEDETTI, S; DAVIO, C.

Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum.

CANCER LETTERS; Año: 2004 vol. 210 p. 179 - 188

FITZSIMONS C; MONCZOR F; FERNANDEZ N; SHAYO C; DAVIO C

Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein.

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2004 vol. 279 p. 34431 - 34439

MONCZOR, F; FERNANDEZ, N; LEGNAZZI, B. L.; RIVEIRO, M. E.; BALDI, A.; SHAYO, C.; DAVIO, C.

Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model

MOLECULAR PHARMACOLOGY; Año: 2003 vol. 64 p. 512 - 520

FERNANDEZ N; MONCZOR F; LEMOS B; NOTCOVICH C; BALDI A; DAVIO C; SHAYO C

Reduction of G protein-coupled receptor kinase 2 expression in U-937 cells attenuates H2 histamine receptor desensitization and induces cell maturation.

MOLECULAR PHARMACOLOGY; Lugar: Bethesda, MD, USA; Año: 2002 vol. 62 p. 1506 - 1514

SHAYO C; FERNANDEZ, N.; LEGNAZZI, B. L.; MONCZOR, F.; MLADOVAN, A.; BALDI, A.; DAVIO, C.

Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases

MOLECULAR PHARMACOLOGY; Año: 2001 vol. 60 p. 1049 - 1056

LEMOS LEGNAZZI, B.; SHAYO, C.; MONCZOR, F.; MARTIN, M. E.; FERNANDEZ, N.; BRODSKY, A.; BALDI, A.; DAVIO, C.

Rapid desensitization and slow recovery of the cyclic AMP response mediated by histamine H(2) receptors in the U937 cell line

BIOCHEMICAL PHARMACOLOGY; Año: 2000 vol. 60 p. 159 - 166