SAHORES, ANA; GONZÁLEZ, ANGELA RODRÍGUEZ; YANEFF, AGUSTÍN; MAY, MARÍA; GÓMEZ, NATALIA; MONCZOR, FEDERICO; FERNÁNDEZ, NATALIA; DAVIO, CARLOS; SHAYO, CARINA

Ceefourin-1, a MRP4/ABCC4 inhibitor, induces apoptosis in AML cells enhanced by histamine

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS; Año: 2023 vol. 1867

ECHEVERRÍA, EMILIANA; RIPOLL, SONIA; FABIÁN, LUCAS; SHAYO, CARINA; MONCZOR, FEDERICO; FERNÁNDEZ, NATALIA C.

Novel inhibitors of phosphorylation independent activity of GRK2 modulate cAMP signaling

Pharmacology Research and Perspectives; Año: 2022 vol. 10

BURGHI, VALERIA; ECHEVERRÍA, EMILIANA B.; ZAPPIA, CARLOS D.; DÍAZ NEBREDA, ANTONELA; RIPOLL, SONIA; GÓMEZ, NATALIA; SHAYO, CARINA; DAVIO, CARLOS A.; MONCZOR, FEDERICO; FERNÁNDEZ, NATALIA C.

Biased agonism at histamine H1 receptor: Desensitization, internalization and MAPK activation triggered by antihistamines

EUROPEAN JOURNAL OF PHARMACOLOGY; Año: 2021 vol. 896

RODRÍGUEZ GONZÁLEZ, ANGELA; SAHORES, ANA; DÍAZ-NEBREDA, ANTONELA; YANEFF, AGUSTÍN; DI SIERVI, NICOLÁS; GÓMEZ, NATALIA; MONCZOR, FEDERICO; FERNÁNDEZ, NATALIA; DAVIO, CARLOS; SHAYO, CARINA

MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux

FEBS JOURNAL; Año: 2021 vol. 288 p. 229 - 243

SAHORES, A.; CAROZZO, A.; MAY, M.; GÓMEZ, N.; DI SIERVI, N.; DE SOUSA SERRO, M.; YANEFF, A.; RODRÍGUEZ-GONZÁLEZ, A.; ABBA, M.; SHAYO, C.; DAVIO, C.

Multidrug transporter MRP4/ABCC4 as a key determinant of pancreatic cancer aggressiveness

Scientific Reports; Año: 2020 vol. 10

SALINAS, FRANCO MAXIMILIANO; NEBREDA, ANTONELA DÍAZ; VÁZQUEZ, LUCIANA; GENTILINI, MARÍA VIRGINIA; MARINI, VICTORIA; BENEDETTI, MARTINA; NABAES JODAR, MERCEDES SOLEDAD; VIEGAS, MARIANA; SHAYO, CARINA; BUENO, CARLOS ALBERTO

Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs

ANTIVIRAL RESEARCH; Año: 2020 vol. 179

ECHEVERRÍA, EMILIANA; CABRERA, MAIA; BURGHI, VALERIA; SOSA, MÁXIMO; RIPOLL, SONIA; YANEFF, AGUSTÍN; MONCZOR, FEDERICO; DAVIO, CARLOS; SHAYO, CARINA; FERNÁNDEZ, NATALIA

The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

Frontiers in Pharmacology; Año: 2020 vol. 11

DÍAZ NEBREDA, ANTONELA; ZAPPIA, CARLOS DANIEL; RODRÍGUEZ GONZÁLEZ, ANGELA; SAHORES, ANA; SOSA, MÁXIMO; BURGHI, VALERIA; MONCZOR, FEDERICO; DAVIO, CARLOS; FERNÁNDEZ, NATALIA; SHAYO, CARINA

Involvement of histamine H 1 and H 2 receptor inverse agonists in receptor's crossregulation

EUROPEAN JOURNAL OF PHARMACOLOGY; Año: 2019 p. 42 - 52

YANEFF, AGUSTÍN; SAHORES, ANA; GOMEZ, NATALIA; CAROZZO, ALEJANDRO; SHAYO, CARINA; DAVIO, CARLOS

MRP4/ABCC4 as a new therapeutic target: meta-analysis to determine cAMP binding sites as a tool for drug design

CURRENT MEDICINAL CHEMISTRY.; Año: 2019 vol. 25

CAROZZO, ALEJANDRO; YANEFF, AGUSTÍN; GÓMEZ, NATALIA; DI SIERVI, NICOLÁS; SAHORES, ANA; DIEZ, FEDERICO; ATTORRESI, ALEJANDRA I.; RODRÍGUEZ-GONZÁLEZ, ÁNGELA; MONCZOR, FEDERICO; FERNÁNDEZ, NATALIA; ABBA, MARTÍN; SHAYO, CARINA; DAVIO, CARLOS

Identification of MRP4/ABCC4 as a Target for Reducing the Proliferation of Pancreatic Ductal Adenocarcinoma Cells by Modulating the cAMP Efflux

MOLECULAR PHARMACOLOGY; Año: 2019 vol. 96 p. 13 - 25

ZAPPIA, CARLOS D.; SOTO, ARIADNA; GRANJA-GALEANO, GINA; FENOY, IGNACIO; FERNANDEZ, NATALIA; DAVIO, CARLOS A.; SHAYO, CARINA; FITZSIMONS, CARLOS P.; GOLDMAN, ALEJANDRA; MONCZOR, FEDERICO

Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model

Pharmacology Research & Perspectives; Año: 2019 vol. 7

MONCZOR F; COPSEL S; FERNANDEZ N; DAVIO C; SHAYO C

Histamine H2 receptor in blood cells: a suitable target for the treatment of acute myeloid leukemia

Handbook of Experimental Pharmacology; Año: 2017 vol. 241 p. 141 - 160

GRANJA-GALEANO, GINA; ZAPPIA, CARLOS DANIEL; FABIÁN, LUCAS; DAVIO, CARLOS; SHAYO, CARINA; FERNÁNDEZ, NATALIA; MONCZOR, FEDERICO

Effect of mutation of Phe 2436.44 of the histamine H2 receptor on cimetidine and ranitidine mechanism of action

BIOCHEMICAL PHARMACOLOGY; Año: 2017 vol. 146 p. 117 - 126

ALONSO N; DIAZ NEBREDA, A; MONCZOR F; GUTKIND JC; DAVIO C; FERNANDEZ N; SHAYO C

PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS; Lugar: Amsterdam; Año: 2016 vol. 1860 p. 1999 - 2007

ALONSO N; ZAPPIA C; CABRERA M; DAVIO C; SHAYO C; MONCZOR F; FERNANDEZ N

Physiological implications of biased signaling at histamine H2 receptors

Frontiers in Pharmacology; Año: 2015

CABRERA M; GOMEZ N; REMES LENICOV F; ECHEVERRIA E; SHAYO C; MOGLIONI A; FERNANDEZ N; DAVIO C

G2/M cell cycle arrest and tumor selective apoptosis of acute leukemia cells by a promising benzophenone thiosemicarbazone compound.

PLOS ONE; Lugar: San Francisco; Año: 2015

CAROZZO A; DIEZ F; GOMEZ N; CABRERA M; SHAYO C ; DAVIO C; FERNANDEZ N

Dual Role of cAMP in the Transcriptional Regulation of Multidrug Resistance-Associated Protein 4 (MRP4) in Pancreatic Adenocarcinoma Cell Lines.

PLOS ONE; Lugar: San Francisco; Año: 2015

ZAPPIA C; GRANJA GALEANO G; FERNANDEZ N; SHAYO C; DAVIO C; FITZSIMONS CP; MONCZOR F

Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways

Scientific Reports; Año: 2015

COPSEL S; BRUZZONE A; MAY M; BEYRATH J; WARGON V; CANY J; RUSSEL FGM; SHAYO C; DAVIO C

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia

Oncotarget; Año: 2014

ALONSO N; MONCZOR F; ECHEVERRIA E; DAVIO C; SHAYO C; FERNANDEZ N

Signal transduction mechanism of biased ligands at histamine H2 receptors.

BIOCHEMICAL JOURNAL; Lugar: Londres; Año: 2014 vol. 459 p. 117 - 126

ALONSO N; FERNANDEZ N; NOTCOVICH C; MONCZOR F; SIMAAN M; BALDI A; GUTKIND JC; DAVIO C; SHAYO C

Cross-Desensitization and Cointernalization of H1 and H2 Histamine Receptors Reveal New Insights into Histamine Signal Integration

MOLECULAR PHARMACOLOGY; Lugar: Baltimore; Año: 2013 vol. 83 p. 1087 - 1098

VAZQUEZ R; RIVEIRO ME; MONDILLO C; PERAZZO JC; VEURMEULEN M; BALDI A; DAVIO C; SHAYO C

Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-1 induced selective cytotoxicity towards U-937 leukemic 2 cells versus mature monocytes: cytoplasmic p21Cip1/WAF1 as 3 resistance factor.

BIOCHEMICAL PHARMACOLOGY; Año: 2013 vol. 86 p. 210 - 221

MONCZOR F; FERNANDEZ NC; FITZSIMONS CP; SHAYO C; DAVIO C

Antihistaminergics and inverse agonism. Potential therapeutic applications.

EUROPEAN JOURNAL OF PHARMACOLOGY; Lugar: Amsterdam; Año: 2013 vol. 715 p. 26 - 32

VAZQUEZ R; RIVEIRO ME; VERMEULEN M; MONDILLO C; COOMBES PH; CROUCH NR; ISMAIL F; MULLHOLAND DA; BALDI A; SHAYO C; DAVIO C

Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells

PHYTOMEDICINE; Año: 2012 vol. 19 p. 737 - 746

VAZQUEZ R; RIVEIRO ME; VERMEULEN M; ALONSO E; MONDILLO C; FACORRO G; PIEHL L; GOMEZ N; MOGLIONO A; FERNANDEZ N; BALDI A; SHAYO C; DAVIO C

Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: Key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action.

BIOORGANIC & MEDICINAL CHEMISTRY.; Lugar: Amsterdam; Año: 2012 vol. 20 p. 5537 - 5549

COPSEL S; GARCÍA C; DIEZ F; VERMEULEN M; BALDI A; BIANCIOTTI L; RUSSEL FGM; SHAYO C; DAVIO C

Multidrug Resistance Protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2011 vol. 286 p. 6979 - 6988

GOMEZ N; SANTOS D; VAZQUEZ R; SUESCUN L; MOMBRU A; VERMEULEN M; FINKIELSZTEIN L; SHAYO C; MOGLIONI A; GAMBINO D; DAVIO C

Synthesis, structural characterization and pro-apoptotic activity of Indanone thiosemicarbazones and their platinum (II) and paladium (II) complexes: Potential role as selective antileukemic agents

CHEMMEDCHEM; Lugar: Weinheim; Año: 2011 vol. 6 p. 1485 - 1494

FERNANDEZ N; GOTTARDO F; ALONSO N; MONCZOR F; SHAYO C; DAVIO C

1. Roles of phosphorylation dependent and independent mechanisms in the regulation of Histamine H2 receptor by G Protein-coupled Receptor Kinase

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2011 vol. 286 p. 28697 - 28706

NOTCOVICH C; DIEZ F; TUBIO MR; BALDI A; KAZANIETZ MG; DAVIO C; SHAYO C

Histamine acting on H1 receptor promotes inhibition of proliferation via PLC, RAC, and JNK-dependent pathways

EXPERIMENTAL CELL RESEARCH; Año: 2010 vol. 316 p. 401 - 411

RIVEIRO ME; DE KIMPE N; MOGLIONI A; VAZQUEZ R; MONCZOR F; SHAYO C; DAVIO C

Coumarins: Old compounds with novel promising therapeutic perspectives

CURRENT MEDICINAL CHEMISTRY.; Año: 2010 vol. 17 p. 1325 - 1338

TIBIO MR; FERNANDEZ NC; FITZSIMONS CP; COPSEL S; SANTIAGO SD; SHAYO C; DAVIO C; MONCZOR F

The expression of a g protein coupled receptor (GPCR) leads to the attenuation of other GPCRs signaling. Experimental evidence for a spontaneous GPCR constitutive inactive form.

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2010 vol. 285 p. 14990 - 14998

RIVEIRO ME; MAES D; VAZQUEZ R; VERMEULEN M; MANGELINCKX S; JACOBS J; DEBENEDETTI S; SHAYO C; DE KIMPE N; DAVIO C

Towards establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells

BIOORGANIC & MEDICINAL CHEMISTRY.; Año: 2009 vol. 17 p. 6547 - 6559

FERNANDEZ N; MONCZOR F; BALDI A; DAVIO C; SHAYO C

Histamine H2 receptor trafficking: Role of arrestin, dynamin and clathrin

MOLECULAR PHARMACOLOGY; Año: 2008 vol. 74 p. 1109 - 1118

RIVEIRO ME, ; VAZQUEZ R; MOGLIONI A; GOMEZ N; BALDI A; DAVIO C; SHAYO C

Biochemical mechanisms underlying the pro-apoptotic activity of 7,8-dihydroxy-4-methylcoumarin in human leukemic cells

BIOCHEMICAL PHARMACOLOGY; Año: 2008 vol. 75 p. 725 - 736

RIVEIRO ME; MOGLIONI A; VAZQUEZ R; GOMEZ N; FACORRO G; PIEHL L; RUBIN DE CELIS E; SHAYO C; DAVIO C

Structural insights into hydroxycoumarins-induced apoptosis in U-937 cells

BIOORGANIC & MEDICINAL CHEMISTRY.; Año: 2008 vol. 16 p. 2665 - 2675

MAES D; RIVEIRO ME; SHAYO C; DAVIO C; DEBENEDETTI S; DE KIMPE N

Total synthesis of naturally occurring 5,6,7- and 5,7,8-trioxygenated coumarins

TETRAHEDRON; Año: 2008 vol. 64 p. 4438 - 4443

FERNANDEZ N; MONCZOR F; TUBIO MR; SHAYO C; DAVIO C

Regulatory mechanisms underlying GKR2 levels in U937 cells. Evidence for GRK3 involvement

BIOCHEMICAL PHARMACOLOGY; Año: 2007 vol. 73 p. 1758 - 1767

MONCZOR F, FERNANDEZ N, RIVEIRO E, MLADOVAN A, BALDI A, SHAYO C, DAVIO C.

4. Histamine H2 overexpression induces U937 cell differentiation despite triggered mechanisms to attenuate cAMP signalling

BIOCHEMICAL PHARMACOLOGY; Año: 2006 vol. 71 p. 1219 - 1228

SHAYO C, LEMOS LEGNAZZI B, MONCZOR F, FERNANDEZ N, RIVEIRO ME, BALDI A, DAVIO C.

7. The time-course of the cAMP signaling is critical for the differentiation in human leukemia U-937 cells

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Año: 2004 vol. 314 p. 798 - 804

RIVEIRO ME, SHAYO C, MONCZOR F, FERNÁNDEZ N, BALDI A, DE KIMPE N, ROSSI J, DEBENEDETTI S, DAVIO C

6. Induction of cell differentiation by 5-oxy-6,7-methylenedioxycoumarins from Pterocaulon polystachyum, in human leukemia U-937 cells

CANCER LETTERS; Año: 2004 vol. 210 p. 179 - 188

FITZSIMONS CP, MONCZOR F, FERNANDEZ N, SHAYO C, DAVIO C.

5. Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2004 vol. 279 p. 34431 - 34439

FERNANDEZ N; MONCZOR F; LEMOS LEGNAZZI B; NOTCOVICH C; BALDI A; DAVIO C; SHAYO C

Reduction of G Protein-Coupled Receptor Kinase 2 Expression in U-937 Cells Attenuates H2 Histamine Receptor Desensitization and Induces Cell Maturation

MOLECULAR PHARMACOLOGY; Año: 2002 vol. 62 p. 1506 - 1514

SHAYO C; FERNANDEZ N; LEMOS LEGNAZZI B; MONCZOR F; MLADOVAN A; BALDI A; DAVIO C

Histamine H2 Receptor Desensitization: Involvement of a Select Array of G Protein-Coupled Receptor Kinases

MOLECULAR PHARMACOLOGY; Año: 2001 vol. 60 p. 1049 - 1056