INVESTIGADORES
BOCCIA Mariano Martin
artículos
Título:
Sildenafil, a selective phosphodiesterase 5 inhibitor, enhances memory reconsolidation of an inhibitory avoidance task in mice.
Autor/es:
BOCCIA MM; BLAKE MG; KRAWCZYK MC; BARATTI CM
Revista:
BEHAVIOURAL BRAIN RESEARCH
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: AMSTERDAM; Año: 2011 vol. 220 p. 319 - 324
ISSN:
0166-4328
Resumen:
Intracellular
levels of the second messengers cAMP and cGMP are maintained through a balance
between production, carried out by adenyl cyclase (AC) and guanylyl cyclase
(GC), and degradation, carried out by phosphodiesterases (PDEs). Recently, PDEs
have gained increased attention as potential new targets for cognition
enhancement, with particular reference to phosphodiesterase type 5 (PDE5A). It
is accepted that once consolidation is completed memory becomes permanent, but
it has also been suggested that reactivation (memory retrieval) of the original
memory makes it sensitive to the same treatments that affect memory
consolidation when given after training. This new period of sensitivity coined
the term reconsolidation. Sildenafil (1, 3, and 10 mg/kg, ip), a cGMP- PDE5
inhibitor, facilitated retention performance of a one-trial step-through
inhibitory avoidance task, when administered to CF-1 male mice immediately
after retrieval. The effects of sildenafil (1 mg/kg, ip) were time-dependent,
long-lasting and inversely correlated with memory age. The administration of
sildenafil (1 mg/kg, ip) 30 min prior to the 2nd retention test did
not affect retention of mice given post-retrieval injections of either vehicle
or sildenafil (1 mg/kg, ip). Finally, an enhancement of retention was also
observed in CF-1 female mice receiving sildenafil (1 mg/kg, ip) immediately,
but not 180 min after retrieval. In the present paper we reported for the first
time that systemic administration of sildenafil after memory reactivation
enhances retention performance of the original learning. Our results indirectly
point out cGMP, a component of the NO/cGMP/PKG pathway, as a necessary factor for
memory reconsolidation.