Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts

FEDERICO M. DARAY; ANGELES R. ARENA; ARNALDO R. ARMESTO; DEMIÁN E. RODANTE; LEANDRO N. GRENDAS; SOLEDAD PUPPO; PATRICIA VIDJEN; ALICIA PORTELA; ANDREA E. ERRASTI

EUROPEAN PSYCHIATRY

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Lugar: Paris; Año: 2018

0924-9338

Objective: The serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphismsare associated with suicidal behavior; however, prospective studies are scarce. Herein we aim to determine if 5-HTTLPR polymorphisms predict risk of short-term suicide reattempt in a highrisk suicidal sample. We also explore possible mediators or moderators of this relationship.Methods: A multicenter prospective cohort study was designed to compare data obtained form136 patients admitted to the emergency department for current suicidal ideation or a recentsuicide attempt. Subjects were clinically evaluated, genotyped, and monitored for a new suicide attempt for 6 months.Results: At 6 months of follow up, 21% of the subjects had a new suicide attempt. The frequency of L-allele and L-carrier was higher in reattempters when compared with non-reattempters (55.8% vs. 35.4%, p = 0.01 and 76.9% vs. 54.2%, p = 0.04, respectively). Reattempters also differ from non-reattempters patients with respect to age, history of previous suicide attempts, and age of onset of suicidal behavior. The logistic regression model showed that L-carriers had an odds ratio of 2.8 (95% CI: 1.0 ? 7.6) for reattempts when compared to SS genotype. The adjusted model indicates that this association is not mediated or moderated by impulsivity.Conclusion: The 5-HTTLPR polymorphisms predicted short-term risk of suicidal reattemptindependently of age and sex. L-carriers have almost three times more risk of relapse whencompared with SS carriers.