INVESTIGADORES
MARTIN Valentina
artículos
Título:
Toxoplasma gondii infection blocks the development of allergic airway inflammation in BALB/c mice
Autor/es:
FENOY IGNACIO; GIOVANNONI MARCOS; BATALLA ESTELA; MARTIN VALENTINA; FRANK FERNANDA M; PIAZZON ISABEL; GOLDMAN ALEJANDRA
Revista:
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Editorial:
British Society for Immunology
Referencias:
Año: 2009 vol. 155 p. 275 - 284
ISSN:
0009-9104
Resumen:
There is a link between increased allergy and a reduction of some infections
in western countries. Epidemiological data also show that respiratory allergy
is less frequent in people exposed to orofaecal and foodborne microbes such
as Toxoplasma gondii. Infection with T. gondii induces a strong cell-mediated
immunity with a highly polarized T helper type 1 (Th1) response in early
stages of infection. Using a well-known murine model of allergic lung
inflammation, we sought to investigate whether T. gondii infection could
modulate the susceptibility to develop respiratory allergies. Both acute and
chronic infection with T. gondii before allergic sensitization resulted in a
diminished allergic inflammation, as shown by a decrease in bronchoalveolar
lavage (BAL) eosinophilia, mononuclear and eosinophil cell infiltration
around airways and vessels and goblet cell hyperplasia. Low allergen-specific
immunoglobulin (Ig)E and IgG1 and high levels of allergen-specific IgG2a
serum antibodies were detected. A decreased interleukin (IL)-4 and IL-5
production by lymph node cells was observed, while no antigen-specific
interferon-g increase was detected. Higher levels of the regulatory cytokine
IL-10 were found in BAL from infected mice. These results show that both
acute and chronic parasite infection substantially blocked development of
airway inflammation in adult BALB/c mice. Our results support the hypothesis
that T. gondii infection contributes to protection against allergy in
humans.
humans.
humans.
T. gondii infection contributes to protection against allergy in
humans.
IL-10 were found in BAL from infected mice. These results show that both
acute and chronic parasite infection substantially blocked development of
airway inflammation in adult BALB/c mice. Our results support the hypothesis
that T. gondii infection contributes to protection against allergy in
humans.
humans.
humans.
T. gondii infection contributes to protection against allergy in
humans.
IL-10 were found in BAL from infected mice. These results show that both
acute and chronic parasite infection substantially blocked development of
airway inflammation in adult BALB/c mice. Our results support the hypothesis
that T. gondii infection contributes to protection against allergy in
humans.
humans.
humans.
T. gondii infection contributes to protection against allergy in
humans.
diminished allergic inflammation, as shown by a decrease in bronchoalveolar
lavage (BAL) eosinophilia, mononuclear and eosinophil cell infiltration
around airways and vessels and goblet cell hyperplasia. Low allergen-specific
immunoglobulin (Ig)E and IgG1 and high levels of allergen-specific IgG2a
serum antibodies were detected. A decreased interleukin (IL)-4 and IL-5
production by lymph node cells was observed, while no antigen-specific
interferon-g increase was detected. Higher levels of the regulatory cytokine
IL-10 were found in BAL from infected mice. These results show that both
acute and chronic parasite infection substantially blocked development of
airway inflammation in adult BALB/c mice. Our results support the hypothesis
that T. gondii infection contributes to protection against allergy in
humans.
humans.
humans.
T. gondii infection contributes to protection against allergy in
humans.
IL-10 were found in BAL from infected mice. These results show that both
acute and chronic parasite infection substantially blocked development of
airway inflammation in adult BALB/c mice. Our results support the hypothesis
that T. gondii infection contributes to protection against allergy in
humans.
humans.
humans.
T. gondii infection contributes to protection against allergy in
humans.
IL-10 were found in BAL from infected mice. These results show that both
acute and chronic parasite infection substantially blocked development of
airway inflammation in adult BALB/c mice. Our results support the hypothesis
that T. gondii infection contributes to protection against allergy in
humans.
humans.
humans.
T. gondii infection contributes to protection against allergy in
humans.
diminished allergic inflammation, as shown by a decrease in bronchoalveolar
lavage (BAL) eosinophilia, mononuclear and eosinophil cell infiltration
around airways and vessels and goblet cell hyperplasia. Low allergen-specific
immunoglobulin (Ig)E and IgG1 and high levels of allergen-specific IgG2a
serum antibodies were detected. A decreased interleukin (IL)-4 and IL-5
production by lymph node cells was observed, while no antigen-specific
interferon-g increase was detected. Higher levels of the regulatory cytokine
IL-10 were found in BAL from infected mice. These results show that both
acute and chronic parasite infection substantially blocked development of
airway inflammation in adult BALB/c mice. Our results support the hypothesis
that T. gondii infection contributes to protection against allergy in
humans.
humans.
humans.
T. gondii infection contributes to protection against allergy in
humans.
IL-10 were found in BAL from infected mice. These results show that both
acute and chronic parasite infection substantially blocked development of
airway inflammation in adult BALB/c mice. Our results support the hypothesis