Recombinant vaccines and infectious bursal disease virus

LUCERO, MARÍA SOLEDAD; GOMEZ, EVANGELINA; CARBALLEDA, JUAN MANUEL; GRAVISACO, MARÍA JOSÉ; CHIMENO ZOTH, SILVINA; BERINSTEIN, ANALÍA

CAB Reviews

CAB International

Año: 2012 vol. 7 p. 1 - 11

1749-8848

nfectious bursal disease virus (IBDV) is the aetiological agent of infectious bursal disease (IBD), an immunosuppressive and highly contagious disease that affects young birds causing important economic losses in the poultry industry worldwide. Currently, vaccination programmes with inactivated and live-attenuated viruses have been used to prevent IBD. However, these vaccines present a number of disadvantages, mainly because of their viral nature. Consequently, in the last two decades, many studies have been conducted in order to replace conventional virus-based vaccines by new, rationally designed vaccines that are safer as well as effective. In this review, we will present a background on the disease and its causative agent, and focus on the development of new generation vaccines against this significant poultry disease.