INVESTIGADORES
MEDRAN Noelia Soledad
artículos
Título:
Synthesis of a Small Library of Imidazolidin-2-ones using Gold Catalysis on Solid Phase.
Autor/es:
LA VENIA AGUSTINA ; MEDRAN NOELIA S.; VIKTOR KRCHNAK; TESTERO SEBASTIÁN A.
Revista:
ACS Combinatorial Science
Editorial:
American Chemical Society
Referencias:
Año: 2016
ISSN:
2156-8952
Resumen:
An efficient and high-yielding solid phase synthesis of a small library of imidazolidin-2-ones and imidazol-2-ones was carried out employing a high chemo- and regio-selective gold-catalyzed cycloisomerization as a key step. Polymer-supported amino acids derivatized with several alkynes functionalities combined with tosyl- and phenyl-ureas have been subjected to gold-catalysis exhibiting exclusively C-N bond formation. The present work proves the potential of solid phase synthesis and homogeneous gold catalysis as an efficient and powerful synthetic tool for the generation of drug-like heterocycles.?These authors contributed equally to this work. (La Venia A., Medran N.)
