Modeling The Electrical Activity in MyelinatedNerve Fibers: Towards the Electrophysiological Validation of Neuronal Bridges

SOCCI MC; FELICE CJ; DE MARCO NM; ALBARRACIN, AL; GOY CB; FARFÁN FD

Revista Argentina de Bioingeniería

Sociedad Argentina de Bioingeniería

Año: 2020 vol. 4 p. 73 - 79

When severe injuriesoccurin the Central or Peripheric Nervous Tissue, this often triggers events thatpermanently damage the neurological function, which leads to a reduction in the patient?squality of life.The use of bio-materials scaffolding to create bridges that re-establish the lost connections arepromising, but currently, have limited applicability; and electrophysiological and biologicalvalidations demand considerable time, so it is still a field being explored by many investigatorsaround the world.In this paper a simplified empirical model is proposed to describe an action potential generation anconduction through myelinic fibers. The model´s electrophysiological validation was performed through qualitative analysis in three experimental situations that call for action potential: a) sciatic nerve in frog, b) giant lateral axons and giant medial axon in earthworm, and c) infraorbital nerve in rats. Results evidence the proposed empirical model´s great versatility to the different evoked action potentials.The proposed model could become a valuable tool to determine the percentage of functionally connected fibers through neural bridges made of various materials