From Semantic to Social Deficits: Dysfunction of the Nondominant Posterior Perisylvian Area in Schizophrenia

GUINJOAN SALVADOR; DELFINA DE ACHAVAL; VILLAREAL MIRTA; ABUSAMRA VALERIA; CHARLES NEMEROFF

THE JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES.

AMER PSYCHIATRIC PUBLISHING, INC

Lugar: Washington DC; Año: 2015 vol. 27 p. 254 - 261

0895-0172

Schizophrenia is characterized by profound deficits in social competence and functioning, independent from active psychoticsymptoms at different stages of the disease. Social deficits in schizophrenia are clinically well characterized, but their neurobiological underpinnings are undetermined. This article reviews recent evidence supporting heritable deficits in a circuitnecessary for appropriate naming of emotions and mental states in others, centered at the temporoparietal junction of the nondominant hemisphere. The clinical implications of this model are discussed, including the potential use of rehabilitation techniques oriented to recognition and naming of emotions and mental states as a necessary step for social rehabilitation.