ACTIVITIES OF MONOAMINE OXIDASE-A AND B IN ADULT RAT CEREBELLUM FOLLOWING NEONATAL X-IRRADIATION

GUELMAN, L. R; ZIEHER, L. M; ZORRILLA Z., M. A.; DOPICO, A. M

NEUROSCIENCE RESEARCH.

Elsevier

Año: 1996 vol. 25 p. 97 - 100

0168-0102

The activities of monoetmine oxidases, MAO-A and MAO-B, were separately determined in the cerebellum (CE) from adult ratsneonatally exposed to 5 Gy X-irradiation. They were found to be markedly reduced: 58% and 66% of values from nonirradiated,littermate controls. Since the specific activities of both isoenzymes (per mg tissue weight) were not significantly different fromcontrols, the reduction of activity per CE is basically explained by the irradiation-induced cerebellar atrophy. The unmodifiedMAO-A specific activity makes it highly improbable that the increase in the cerebellar noradrenaline content, characteristic ofneonatally X-irradiated rats, could be due to a decreased neuronal metabolism of noradrenaline by this enzyme.