INVESTIGADORES
DUPUY Fernando Gabriel
artículos
Título:
Microcin J25-Ga induces apoptosis in mammalian cells by inhibiting mitochondrial RNA-polymerase
Autor/es:
NIKLISON CHIROU, MARIA VICTORIA; DUPUY, FERNANDO; SAAVEDRA, LUCILA; HEBERT, ELVIRA; BANCHIO, CLAUDIA; MINAHK, CARLOS; MORERO, ROBERTO
Revista:
PEPTIDES
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2011 vol. 32 p. 832 - 834
ISSN:
0196-9781
Resumen:
MccJ25, an antimicrobial peptide, was unable to cause apoptosis of COS-7
cells in spite of inducing reactive-oxygen species overproduction as
well as cytochrome c release from isolated mitochondria.
Surprisingly, MccJ25-Ga, an amidated variant of MccJ25 that displays
similar anti-mitochondrial effects, did induce apoptosis in COS-7. The
only difference found between the activities of these peptides was the
unpredicted inhibition of mitochondrial RNA synthesis by MccJ25-Ga.
These results led us to hypothesize that both mitochondrial RNA
polymerase and mitochondrial membrane might be the molecular targets of
MccJ25-Ga in mitochondria and this combined effect may lead to
apoptosis.