ADIPOCYTOKINE LEVELS IN WOMEN WITH ANOREXIA NERVOSA. RELATIONSHIP WITH WEIGHT RESTORATION AND DISEASE DURATION

XIMENA TERRA; TERESA AUGUET; ZAIDA AGÜERA; ISABEL MARÍA QUESADA; JOSEP MARÍA ORELLANA-GAVALDA; CARMEN AGUILAR; SUSANA JIMÉNEZ-MURCIA; ALBA BERLANGA; ESTEHR GUIU-JURADO; JOSÉ MANUEL MENCHÓN; FERNANDO FERNÁNDEZ ARANDA; CRISTÓBAL RICHART

INTERNATIONAL JOURNAL OF EATING DISORDERS

JOHN WILEY & SONS INC

Lugar: New York; Año: 2013 vol. 46 p. 855 - 861

0276-3478

Objective: Starvation-induced depletion of fat stores in anorexia nervosa (AN) isknown to be accompanied by alterations in some circulating adipocytokines. Weanalysed a panel of circulating adipocytokines in women with AN compared withnormal-weight controls and their relation with the disease duration and weightrestoration. Method: We analysed circulating adipocytokine levels in 28 patients withAN and in 33 normal-weight controls who were eating healthily. We determined byELISA the circulating levels of total and high molecular weight (HMW) adiponectin,lipocalin-2 (LCN2), leptin, tumour necrosis factor receptor-II (TNFRII), interleukin-6(IL6), adipocyte fatty acid binding protein-4 (FABP4), ghrelin and resistin. Results: Thetwo circulating forms of adiponectin are higher in AN women compared with controls.Both total and HMW adiponectin related negatively to the duration of the disease (r=-0.372, p=0.033; r=-0.450, p=0.038, respectively). Furthermore, the lipid bindingproteinsLCN2 and FABP4 are lower in AN compared to the control group. Finally,leptin levels are lower in AN against controls and correlated positively with diseaseduration (r=0.537, p=0.007). Resistin, ghrelin, TNFRII, and IL6 have similar values inboth groups, although TNFRII and ghrelin related negatively to BMI variation at the endof treatment (r=-0.456, p=0.039; r=-0.536, p=0.015, respectively). Discussion: Theseresults suggest there is a need to investigate if changes in adipocytokine levels couldserve as weight restoration biomarkers. Further studies are warranted to elucidate thespecific role of these molecules in the timing of weight restoration.