INVESTIGADORES
KAUFFMAN Marcelo Andres
artículos
Título:
Whole genome analysis of the action of interferon-beta
Autor/es:
KAUFFMAN MARCELO; YANKILEVICH PATRICIO; BARRERO PAOLA; BELLO RICARDO; MARANGUNICH LAURA; CRISCUOLO MARCELO; DIEZ ROBERTO; STERIN-PRYNC AIDA
Revista:
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
Editorial:
DUSTRI-VERLAG DR KARL FEISTLE
Referencias:
Año: 2009 vol. 47 p. 328 - 357
ISSN:
0946-1965
Resumen:
Objectives: To characterize the
IFN1a-regulated gene expression on leukocytes
of Multiple Sclerosis (MS) patients using
microarrays with whole human genome
representation. Methods: Genes differentially
expressed by interferon- were identified by
a microarray in vitro study performed in leukocytes
obtained from 5MS relapsing-remitting
patients. Results: Following the culture
of peripheral blood mononuclear cells from
MS relapsing-remitting patients for 24 hs
with IFN1a, the expression of 868 genes was
modified: 545 increased (including CXCL11,
CCL8, INDO, IFI27, CFB, CXCL10 and
IFIT1) and 323 diminished (including RBP7,
SEPT5, RNF8, ADORA2B and FOS). Conclusions:
Since many of them were previously
recognized as involved in MS pathogenesis,
the IFNb1a mechanism of action
could imply a compensatory regulation of
systems deregulated in MS.