Epigenetic mechanisms and posttranslational modifications in systemic lupus erythematosus

QUIROZ, ELKIN NAVARRO; CHAVEZ-ESTRADA, VALERIA; MACIAS-OCHOA, KARIME; AYALA-NAVARRO, MARÍA FERNANDA; FLORES-AGUILAR, ANIYENSY SARAI; MORALES-NAVARRETE, FRANCISCO; LOPEZ, FERNANDO DE LA CRUZ; ESCORCIA, LORENA GOMEZ; MUSSO, CARLOS G.; MARTINEZ, GUSTAVO AROCA; TORRES, HENRY GONZALES; PEREZ, ANDERSON DIAZ; BONFANTI, ANDRES CADENA; GUTIERREZ, JOANY SARMIENTO; MEZA, JAINY; ARROYO, ESPERANZA DIAZ; LEMUS, YESIT BELLO; AHMAD, MOSTAPHA; QUIROZ, ROBERTO NAVARRO

International Journal of Molecular Sciences

MDPI AG

Año: 2019 vol. 20 p. 56 - 79

1661-6596

The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the differential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.