INVESTIGADORES
FRIES Alexander Erich
artículos
Título:
Synthesis and structural characterisation as 12-helix of the hexamer of a b-amino acid tethered to a pyrrolidin-2-one ring
Autor/es:
ILEANA MENEGAZZO; ALEXANDER FRIES; STEFANO MAMMI; ROBERTA GALEAZZI; GIANLUCA MARTELLI; MARIO ORENA; SAMUELE RINALDI
Revista:
CHEMICAL COMMUNICATIONS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: CAMBRIDGE; Año: 2006 vol. 2006 p. 4915 - 4917
ISSN:
1359-7345
Resumen:
Starting from (3S,4R,19S)-3-amino-2-oxo-1-[19-(4-methoxyphe- nylethyl)]pyrrolidine carboxylic acid (2), the first synthesis of a b-foldamer containing pyrrolidin-2-one rings is described, whose 12-helix conformation is assigned by NMR analysis and confirmed by molecular dynamics (MD) simulations.
