Heteroleptic complexes of antifungal drugs with the silver ion.

GIULIDORI, CECILIA; MOSCONI, NATALIA; TOPLIKAR, BRENDA; VEGA, MARISA; WILLIAMS, PATRICIA; SVETAZ, LAURA; RAIMONDI, MARCELA; RIZZOTTO, MARCELA

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

John Wiley & Sons Ltd

Lugar: Heidelberg; Año: 2016 vol. 29 p. 656 - 664

0894-3230

In spite of a large number of antibiotics and chemotherapeutics available for medical use, the emergence of old and new antibiotic resistance in the last decades revealed a substantial medical need for new classes of antimicrobial agents. In this paper we report the synthesis, characterization by elemental analysis, Fourier transform infrared and Nuclear magneticresonance spectroscopies, and antifungal properties of two heteroleptic complexes of albendazole (albz) with Ag(I), using KSCN and o-phenanthroline (phen) as the second ligand, respectively. Both complexes showed a moderate antifungalactivity with all the assayed fungi, mainly Candida albicans and Candida tropicalis, that showed no activity against albendazole.