Differential effect of erythropoietin and carbamylated erythropoietin on endothelial cell migration.

MALTANERI ROMINA EUGENIA; CHAMORRO MARÍA EUGENIA; SCHIAPPACASSE AGUSTINA; NESSE, ALCIRA; VITTORI DANIELA

INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELLULAR BIOLOGY

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2017 vol. 85 p. 25 - 34

1357-2725

We have demonstrated a differential effect between Epo and its carbamylated derivative on endothelial cell migration. Such difference appears to depend on a premature ter-mination of the cEpo signal due to the enhanced phosphatase activity of PTP1B, as we have previously reported for erythroid cells. Accordingly, Epo-induced migration seems to rely on the classical homodimeric receptor. Although cEpo is devoided of Epo?s ability to stimulate migration, it retains its protective action against ROS generation. We believe that the present results provide new insights into the action mechanisms of Epo and cEpo in non-hematopoietic tissues.