Role of Oxidative Stress in Lithium- Induced Nephropathy

OSSANI, GEORGINA.; UCEDA, ANA; ACOSTA, JUAN MANUEL; LAGO, NÉSTOR; REPETTO, MARISA GABRIELA; MARTINO, DIEGO; TOBBLI,JORGE

BIOLOGICAL TRACE ELEMENT RESEARCH

HUMANA PRESS INC

Lugar: Oregon; Año: 2018

0163-4984

Long-term lithium treatment was associated with chronic kidney disease and renal failure although the underlying pathogenicmechanisms are not certainty known. The aim of this study was to evaluate changes in oxidative stress measures as well as renalfunctional and structural alterations associated with chronic use of lithiumin rats. FortyWistarmale rats were randomized into fourgroups: control groups fed ad libitum powered standard diet for 1 and 3 months and experimental groups fed ad libitum the samediet supplemented with 60 mmol/kg diet for 1 and 3 months. Histopathological changes, laboratory parameters, and oxidativestress measurements were assessed at months 1 and 3. The experimental animals showed alteration of the cortical tubules from thefirst month of lithium-treatment and a decrease in the glomerular filtration rate and in the glomerular area at the third month. Therewas an increase in thiobarbituric acid reactive substances and carbonyls, as well as an increase in reduced glutathione, in the kidneyof rats exposed to lithium. These changes were evident from the first month of treatment and remained throughout the experiment.Our results suggest that, oxidative stress could be one of the pathogenic mechanisms involved in the structural and functionalalterations of the kidney associated with prolonged use of lithium. The study of the pathogenic mechanisms involved in lithiuminducednephropathy is a critical issue for the development of new strategies for prevention and/or early detection.