Induction of apoptosis in the bursa of Fabricius by vaccination against Gumboro disease

KILLIAN, MJ.; BOVIEZ, JD.; GAMBAROTTA, MC.; LOMBARDO, DM.

AVIAN PATHOLOGY

TAYLOR & FRANCIS LTD

Lugar: Londres; Año: 2017 p. 1 - 9

0307-9457

POST-VACCINATION APOPTOTICS EFFECTS AGAINST GUMBORO DISEASE IN FABRICIUS BURSA SUMMARY Infectious bursal disease is an acute viral, highly contagious disease of young chicken, characterized by affecting mainly the B-lymphocyte cell in the bursa of Fabricius, and leading to severe immunosuppression. Many of the infected B-lymphocytes die from mechanisms that involve necrosis, but recent research reveals that immunosuppression could be the result of the death of linfoid cells due to apoptosis mechanisms. Vaccination has appeared to be a crucial factor for both control and prevention, being the live or parcially or totally inactivated vaccines the most used. However, the appearance of outbreak of the disease due to very virulent mutant strain has raised doubts about the rol of those vaccines. Avian production in our country has had an important development and growth, and the use of different kinds of vaccine is of common practice. This paper determined the apoptotic effect caused by the most used vaccines in local production over the bursa of Fabricius cells and the correlation with histologycal changes.