Lipid Metabolism and Relevant Disorders to Female Reproductive Health

FERRER, MARÍA JOSÉ; SILVA, AIMÉ FLORENCIA; ABRUZZESE, GISELLE ADRIANA; VELÁZQUEZ, MARIELA EDITH; MOTTA, ALICIA BEATRIZ

CURRENT MEDICINAL CHEMISTRY.

BENTHAM SCIENCE PUBL LTD

Año: 2021 vol. 28

0929-8673

Background: Lipids are essential components of cells that participate in metabolic and endocrine regulation and reproductive functions. The main organs where lipid regulation takes place are the liver and adipose tissue. Besides, when each tissue specific action cannot be exerted, it could lead to several endocrine-metabolic disorders closely related to PCOS, such as non-alcoholic fatty liver disease (NAFLD) and obesity.Objective: This work aims to discuss the impact of lipid alterations on metabolic and reproductive health. Therefore, this review focus on the importance of carrying out an integrated study of the molecular pathways affected in PCOS for developing target therapies.Results: Lipids play a major role in PCOS pathogenesis. In this regard, failures in lipid regulation, synthesis, and/or homeostasis contribute to metabolic and reproductive abnormalities, such as those seen in PCOS. Several lipid pathways and regulators are altered in this pathology, leading to dysfunctions that worsen reproductive functions. Therefore, there are several treatments to manage dyslipidemias. Non-pharmacological therapies are considered a first line treatment being the pharmacological treatments a second line option.Conclusion: The best treatment to improve the lipid profile is a lifestyle intervention, a combination of hypocaloric diet and exercise. Regarding pharmacological therapies, a combination of fibrate and statins would be the most recommended drugs. Still, in PCOS women, treatment with metformin or TZDs not only modulates the lipid metabolism, but also improves the ovulation. Also, metformin with lifestyle interventions has positive effects on the metabolic and reproductive features of PCOS patients.