INVESTIGADORES
MAZZUCA Marcia
artículos
Título:
Secochiliode ester derivatives: preparation and evaluation of their antiparasitic and antimalarial efficacy
Autor/es:
ROMINA RONCHI; CLAIRE BEAUFAY; JOANNE BERO; JUAN BAUTISTA ROBIROSA; MARCIA MAZZUCA; JORGE A. PALERMO; JÖELLE QUENTIN LECLERCQ; MARIANELA SÁNCHEZ
Revista:
CHEMICAL BIOLOGY & DRUG DESIGN
Editorial:
John Wiley & Sons
Referencias:
Lugar: Oxford; Año: 2019 vol. 93 p. 147 - 153
ISSN:
1747-0277
Resumen:
A series of new esters of secochiliolide acid (SA) were synthesized and evaluated for their in vitro antiparasitic properties (on Plasmodium falciparum and Trypanosoma brucei brucei).The in vivo antimalarial efficacy of the n-hexyl ester of SA was assessed on mice.An intraperitoneal treatment at 50mg/kg/d induced 56.0 ± 8.2% of parasiteamia inhibition on day 4 post-infection and an increase on the survival time.
