INVESTIGADORES
FAILLACE Maria paula
artículos
Título:
Diurnal variations in cyclic AMP and melatonin content of golden hamster retina.
Autor/es:
FAILLACE MP, KELLER SARMIENTO MI, LEONARDO NICOLA SIRI, ROSENSTEIN RE
Revista:
JOURNAL OF NEUROCHEMISTRY
Editorial:
Wiley InterScience
Referencias:
Año: 1994 vol. 62 p. 1995 - 2000
ISSN:
0022-3042
Resumen:
The diurnal variations and photic regulation of cyclic AMP and
melatonin content in golden hamster retina were studied. Both
parameters showed significant diurnal variations with maximal values at
night. Light exposure during the night inhibited retinal cyclic AMP and
melatonin levels, whereas exposure to darkness during the day
significantly increased cyclic AMP and melatonin content. Incubation
with melatonin of retinas excised at different intervals indicated that
the methoxyindole inhibited cyclic AMP accumulation in a time-dependent
manner. The inhibitory effect of melatonin at 2400 h and at noon showed
a threshold concentration of 1 and 10 pM, respectively. At 0400 h
melatonin did not affect cyclic AMP accumulation. The results indicate
a diurnal variability of retinal cyclic AMP and melatonin content in
hamsters, mainly influenced by a photic stimulus. Cyclic AMP could be a
putative second messenger for melatonin action in golden hamster
retina.