INVESTIGADORES
MARTINEZ SAYE Melisa Soledad
artículos
Título:
Expanding the scope of synthetic 1,2,4-trioxanes towards Trypanosoma cruzi and Leishmania donovani
Autor/es:
MEDRAN N; MARTÍNEZ SAYÉ M; PEREIRA CA; TEKWANI BL; LA VENIA A; LABADIÉ G
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2020
ISSN:
0960-894X
Resumen:
A series of synthetic 1,2,4-trioxanes related to artemisinin was tested against L. donovani and T.cruzi parasites. This screening identified some active compounds, with key common structuralfeatures. Interestingly, these selected trioxanes were efficient against both parasites, andachieved antiparasitic activities comparable or superior than those presented by thecorresponding reference drugs, artemisinin and artesunate. This study represents the firstexample of synthetic trioxanes evaluated on T. cruzi and provides possible candidates fordeveloping new drugs for the treatment of leishmaniasis and Chagas disease.
