INFIQC 05475
INSTITUTO DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Room-Temperature and Transition-Metal-Free Intramolecular α-Arylation of Ketones: A Mild Access to Tetracyclic Indoles and 7-Azaindoles
Autor/es:
ADOUAMA, CHÉRIF; BUDÉN, MARÍA E.; PUIATTI, MARCELO; JOSEPH, BENOÎT; ROSSI, ROBERTO A.; GUERRA, WALTER D.; MÉDEBIELLE, MAURICE; BAROLO, SILVIA M.
Revista:
ORGANIC LETTERS
Editorial:
AMER CHEMICAL SOC
Referencias:
Año: 2019 vol. 21 p. 320 - 324
ISSN:
1523-7060
Resumen:
A novel approach for the synthesis of tetracyclic indoles and 7-azaindoles is reported. The strategy involves four steps, with a fast rt intramolecular α-arylation of ketones as key step. The reaction was inspected synthetically to achieve the synthesis of 11 novel tetracyclic structures with moderate to very good yields (39-85%). Theoretical combined with experimental studies led us to propose a probable polar mechanism (concerted S N Ar).
