Square Wave Voltammetry: An Alternative Technique to Determinate Piroxicam Release Profiles from Nanostructured Lipid Carriers

JESSICA OTAROLA; MARIANO GARRIDO; N. MARIANO CORRES; PATRICIA G. MOLINA

Chemphyschem

WILEY-V C H VERLAG GMBH

Lugar: Weinheim; Año: 2016 vol. 17 p. 2322 - 2328

1439-4235

A new, simple, and fast electrochemical (EC) method has beendeveloped to determine the release profile of piroxicam, a nonsteroidalanti-inflammatory drug, loaded in a drug deliverysystem based on nanostructured lipid carriers (NLCs). For thefirst time, the samples were analyzed by using square wavevoltammetry, a sensitive EC technique. The piroxicam EC responsesallow us to propose a model that explains the experimentalresults and to subsequently determine the amount ofdrug loaded into the NLCs formulation as a function of time. Invitro drug release studies showed prolonged drug release (upto 5 days), releasing 60% of the incorporated drug. The proposedmethod is a promising and stable alternative for thestudy of different drug delivery systems.