The role of mitochondria in inflammatory syndromes

VIRGINIA VANASCO; MARCHINI TIMOTEO; MAGNANI NATALIA; VICO TAMARA; GARCÉS, MARIANA; CACERES LOURDES; GUAGLIANONE ALEJANDRO; EVELSON PABLO; ALVAREZ SILVIA

BIOCELL

INST HISTOL EMBRIOL-CONICET

Lugar: Mendoza; Año: 2016

0327-9545

Several authors have addressed the importance of mitochondrial function ininflammatory syndromes, as it may play a role in the genesis of tissue injury. Sepsis and exposition to environmental particles are examples of inflammatory conditions. Sepsis occurs with an exacerbated inflammatory response that damages tissue mitochondria and impairs bioenergetic processes. One of the current hypotheses for the molecular mechanisms underlying the complex condition of sepsis is that enhanced NO production and oxidative stress lead to mitochondrial dysfunction, bioenergetic derangement and organ failure. The mechanism of particulate matter-health effects are believed to involve inflammation and oxidative stress. Components in particles that elicit inflammation havebeen poorly investigated, although recent research points out to the contribution of compositional elements and particle size. Oxygen metabolism and mitochondrial function appear to be important areas of study in inflammatory conditions for clarifying molecular mechanisms involved