Marcadores tempranos de daño oxidativo y su relación con factores de riesgo en una localidad ambientalmente expuesta a agroquímicos

ODETTI L. M; DECHIARA, P.; MARINO, D.; SIMONIELLO, M.F.

FABICIB

UNL

Lugar: Santa Fe; Año: 2016

0329-5559

the aim of this study was to evaluate oxidative damage generated by environmental exposure to agrochemical mixtures in people living in santo domingo, santa Fe, Argentina and to compare them with healthy non-exposed people from santa Fe city. the activity of catalase (cAt), superoxide dismutase (sod) and thiobarbituric Acid Reactive substances (tbARs) were analyzed. in addition, the results were analyzed in relation to the variables obtained from interviews (confounding factors and health events).the results of oxidative biomarkers showed significant differences in tbARs and sod between the group of people environmentally exposed to pesticides and the control group. . A significant linear regression between tbARs with cAt and sod was found taking into accountthe period of applicationof pesticides,significant differences were found in the three biomarkers. the environmental exposure to pesticides was confirmed by measurements of atrazine residues in rainwater samples from santo domingo.this is a pioneer study in santa Fe province and allowed to link imbalances in oxidative state with factors that could affect health