Prothrombothic state associated with olanzapine treatment in rabbits

CORRALES, A.; ERIMBAUE, M.; ALDERETE, M.; SIERRA, L.; ROCO, J.; TAGASHIRA, C.; MEDINA, M.; JEREZ, S.

BIOCELL 44, (suppl.2 ) 2020.

TUCUMAN BIOLOGY ASSOCIATION

Lugar: San Miguel de Tucumán; Año: 2020 vol. 44 p. 12 - 12

1667-5746

Olanzapine (O) is an atypical or second-generation antipsychotic used in the treatment of psychiatric diseases. It is known to producemetabolic disorders such as Metabolic Syndrome (MS); however, the prothrombotic state, typical of MS, has not been studied. This workaimed to evaluate the metabolic alterations and the prothrombotic variables in rabbits treated with O. Male rabbits were administered withthe vehicle (control group, CG) for five weeks or treated with 3 mg/kg weight O (OG group). Body weight, visceral fat, lipidogram,creatinine, transaminases, and glucose tolerance were evaluated. From platelet-rich plasma (PRP), the morphology of platelets and thefibrin network were studied by scanning electron microscopy. The activated partial thromboplastin time (APTT) and recalcification andconcentration of fibrinogen were measured. There were no changes in lipidogram, transaminases, and visceral fat. Body weight andcreatinine levels increased, and induced glucose intolerance. The platelets of the CG were spherical with few pseudopods, while the OGpresented numerous pseudopods and extensions indicating activation. The fibrin network of the CG consisted of fine and thick fibers withan organized arrangement, while in the OG there was a predominance of fine fibers (p ˂ 0.05), forming a less tense fibrin network.Therefore, the treatment with O altered glucose metabolism, renal function, and produced a prothrombotic state with premature activationof platelets and the formation of an altered fibrin network.