Effect of prenatal stress and forced swimming acute stress on adult rat?s skeletal muscle and liver MDA levels

LIAUDAT ANA CECILIA; RODRÍGUEZ NANCY; BECERRA KAREN; BECERRA KAREN; SOSA EMILIANO JOSE; HUCK GUILLERMO; SOSA EMILIANO JOSE; HUCK GUILLERMO; LIAUDAT ANA CECILIA; RODRÍGUEZ NANCY

MOJ Anatomy and Physiology

MedCrave Group

Lugar: Oklahoma; Año: 2019 vol. 6 p. 226 - 231

2471-139X

The study of stress physiological consequences has gained importance. Accordingly,prenatal stress is a contributing factor on mammal gestation, causing adaptive disturbancesduring offspring adult life. The aim of this study was to analyze the physiological effectsof prenatal stress rats on some skeletal muscle and liver parameters after forced swimming(FS) exposition. Pregnant Wistar rats were stressed by immobilization (IMO) during thetwo last week of pregnancy and male offspring raised in bioterium standard conditionsuntil 90 days old. Corticosterone (COR), Glycaemia and malondialdehyde (MDA) levelswere studied in all experimental group: Control animals, forced swimming stressed ratsand prenatal stressed animals rats with and without FS stress. The results showed that inbasal conditions COR and Glycaemia levels were increased in prenatal stressed animals.After an acute exposition to FS, COR significantly increased in prenatal stress and controlgroups (without prenatal stress). Glycaemia levels had similar values in all experimentalconditions; however, hepatic MDA levels showed a significant increase in prenatal stressedrats and the effect was maintained in FS animals. MDA values analyzed in grooved musclewere higher in prenatal stressed groups, but after FS acute stress, MDA levels increased incontrol animals too. In conclusion, IMO prenatal stress causes a change in the regulation ofhypothalamic-pituitary-adrenal axis (HPA), reflected in high basal levels of plasmatic CORand hyperglycaemia. Moreover, it generates a hyper sensibility to acute stressors causedin post birth life. Also, prenatal stress produces oxidative stress in liver cells while FSstimulates this process in grooved voluntary muscle.