CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
artículos
Título:
Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice
Autor/es:
LUCIANA R FRICK; MARÍA LAURA BARREIRO ARCOS; MAXIMILIANO RAPANELLI; MARÍA LAURA ZAPPIA; MARCELA ADRIANA BROCCO; CLAUDIA MONGINI; ANA MARÍA GENARO; GRACIELA ALICIA CREMASCHI
Revista:
STRESS
Editorial:
Informa Healthcare, Taylor and Francis Group
Referencias:
Año: 2009 vol. 12 p. 134 - 143
ISSN:
1025-3890
Resumen:
Long-term exposure to stressful situations can affect the immune system. The T-cell response is an important component of
anti-tumoral immunity. Hence, impairment of the immune function induced by a chronic stressor has been postulated to alter
the immunosurveillance of tumors, thus leading to a worse neoplastic prognosis. Here, we show that chronic restraint stress
affects T-cell mediated immunity in mice. This was evidenced by a decrease of mitogen-induced T-cell proliferation, a
reduction in CD4þT lymphocyte number and a decrease of tumor necrosis factor-alpha (TNF-a) and Interferon-gamma
(IFN-g) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
(IFN-g) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
(IFN-g) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
(IFN-g) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
(IFN-g) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
(IFN-g) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
(IFN-g) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
þT lymphocyte number and a decrease of tumor necrosis factor-alpha (TNF-a) and Interferon-gamma
(IFN-g) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients
g) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of
tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival.
Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic
exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated
immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the
therapeutic management of stress to improve the prognosis of cancer patients