Effect of garlic?s active constituents in Inflammation, Obesity and Cardiovascular Disease

QUESADA, ISABEL; DEPAOLA, MATILDE; TORRES-PALAZZOLO, CAROLINA; CAMARGO, ALEJANDRA; FERDER, LEÓN; MANUCHA, WALTER; CASTRO, CLAUDIA

CURRENT HYPERTENSION REPORTS

CURRENT MEDICINE GROUP

Año: 2019

1522-6417

Purpose of review: Several studies have attributed garlic´s beneficial properties to its high content of organosulfur compounds (OSCs). Here we summarized recent studies published and some own findings regarding OSCs and its effects on Cardiovascular Disease, Inflammation and Obesity.Recent finding: The analysis of the multiple actions produced by OSCs suggests that many of its bioactivities interfere against inflammation, oxidative stress, obesogenic effects, and mitochondrial dysfunction. Accumulating evidence from in vitro, animal and human studies reinforce the notion that OSCs modulate signaling pathways that trigger prevalent chronic diseases, and to highlight, the actions over such pathways are related to the treatment of some pathologies addressed in this review.Summary: Garlic´s bioactive OSCs behave like a nutraceutical panacea because they cover a broad spectrum of applications with promising impact for the prevention of prevalent chronic diseases associated with low-grade inflammation.