Noscapine‐Loaded Nanostructured Lipid Carriers as a Potential Topical Delivery to Bovine Mastitis Treatment

OTAROLA, JESSICA J.; ALEJANDRA LUNA, MARIA; MARIANO CORREA, NÉSTOR; MOLINA, PATRICIA G.

ChemistrySelect

Wiley-VCH Verlag GmbH & Co. KGaA

Lugar: Weinheim; Año: 2020 vol. 5 p. 5922 - 5927

2365-6549

Noscapine (NO) is a lipophilic benzylisoquinoline alkaloid with antioxidant, antitussive and anti-cancer properties. This study aimed to incorporate this alkaloid into an innovative topical gel-based on nanostructured lipid carrier (NLCs) to facilitate its incorporation and distribution into the organism to bovine mastitis treatment.Drug release studies were carried out using square wave voltammetry (SWV) as an alternative technique. The NLCs showed a 100% encapsulation efficiency and, a fast release profile, releasing 86.7% of the incorporated NO in 5 hours.On the other hand, the lipid nanoparticles? stability was analyzed using SWV and transmission electron microscope techniques. For these studies, NLCs with and without NO incorporated were immobilized onto a carbon paste electrode and exposed to free radicals attack. The stability studies were assisted with dynamic light scattering.The results reveal a promising alternative drug delivery systemfor NO topical application.