Utilidad de la identificación de anticuerpos en neuropatías periféricas, neuronopatías y ganglionopatías: revisión

REISIN, RICARDO C.; SALUTTO, VALERIA L.; AGUIRRE, FLORENCIA; ALVAREZ, VALERIA; BARROSO, FABIO; BENDERSKY, MARIANA; BERARDO, ANDRÉS; BETTINI, MARIELA; BORRELLI, MARIANO M.; CHAVES, MARCELO; CISNEROS, ELISA M.; CONTI, EUGENIA; CRESPO, JOSÉ M.; DI EGIDIO, MARIANA; FIGUEREDO, MARÍA ALEJANDRA; GARGIULO, GISELLA; JÁUREGUI, AGUSTÍN; LANDRISCINA, PAULA; LEÓN CEJAS, LUCIANA; MARTÍNEZ PEREA, MARÍA DEL CARMEN; PIRRA, LAURA; PIVETTA, PAOLA; QUARRACINO, CECILIA; RATTAGAN, MARÍA LUCÍA; REY, ROBERTO; RODRIGUEZ, ALEJANDRO; RODRIGUEZ, GABRIEL E.; RUGIERO, MARCELO; TILLARD, BELEN; ZUBERHBULER, PAZ

Neurología Argentina

Elsevier

Año: 2020 vol. 12 p. 98 - 112

1853-0028

Introduction: Over the last several years the identification of both antineural antibodies andmonoclonal gammopathies allowed a better understanding of pathophysiology and improvementin the diagnosis and treatment of many different immune mediated neuropathies.Objective: To describe the antineural antibodies of greater clinical utility in the diagnosis ofimmune mediated neuropathies and neuronopathies. In each case we underline their valuein either the pathophysiology or diagnosis of these disorders as well as the sensitivity andspecificity of the diagnostic techniques currently in use.Development: We will review the antibodies identified in 1) Guillain-Barré syndrome; 2) Chronicinflammatory demyelinating polyneuropathy (CIDP); 3) Multifocal motor neuropathy(MMN); 4) Chronic Ataxic Neuropathy Ophthalmoplegia M-protein Agglutination Disialosylantibodies syndrome (CANOMAD); 5) Ganglionopathies and Neuropathies and the value ofidentifying monoclonal gammopathies.Conclusions: The antibodies and monoclonal gammopathies are useful tools in both thediagnosis and understanding of the mechanisms involved in immune mediated and cryptogenicneuropathies and orienting treatment.