INVESTIGADORES
CAPANI Francisco
artículos
Título:
Rat hippocampal alterations could underlie behavioral abnormalities induced by exposure to moderate
Autor/es:
S.L. URANA, M.L. AON-BERTOLINO , L.G. CACERESA, F. CAPANI, L.R. GUELMAN,
Revista:
BRAIN RESEARCH
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 1471 p. 1 - 12
ISSN:
0006-8993
Resumen:
Noise exposure is known to affect auditory structures in living organisms. However, it
should not be ignored that many of the effects of noise are extra-auditory. Previous
findings of our laboratory demonstrated that noise was able to induce behavioral
alterations that are mainly related to the cerebellum (CE) and the hippocampus (HC).
Therefore, the aim of this work was to reveal new data about the vulnerability of
developing rat HC to moderate noise levels through the assessment of potential histological
changes and hippocampal-related behavioral alterations. Male Wistar rats were
exposed to noise (95?97 dB SPL, 2 h daily) either for 1 day (acute noise exposure, ANE) or
between postnatal days 15 and 30 (sub-acute noise exposure, SANE). Hippocampal
histological evaluation as well as short (ST) and long term (LT) habituation and recognition
memory assessments were performed. Results showed a mild disruption in the different
hippocampal regions after ANE and SANE schemes, along with significant behavioral
abnormalities. These data suggest that exposure of developing rats to noise levels of
moderate intensity is able to trigger changes in the HC, an extra-auditory structure of the
Central Nervous System (CNS), that could underlie the observed behavioral effects.