CIHIDECAR 12529
CENTRO DE INVESTIGACIONES EN HIDRATOS DE CARBONO
Unidad Ejecutora - UE
artículos
Título:
Quantum dots as ultrasensitive nanoactuators and sensors of amyloid aggregation in live cells.
Autor/es:
ROBERTI, M. J., M. MORGAN, G. MENENDEZ, L. PIETRASANTA, T. M. JOVIN AND E. A. JARES- ERIJMAN
Revista:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Editorial:
AMER CHEMICAL SOC
Referencias:
Año: 2009 vol. 131 p. 8102 - 8107
ISSN:
0002-7863
Resumen:
Quantum dots multifunctionalized with the amyloid protein R-synuclein act at nanomolar concentrations as very potent inducers of the aggregation of micromolar-millimolar bulk concentrations of the protein in vitro and in cells. Fibrillation in live cells, a process diagnostic of Parkinsons disease, is accelerated up to 15-fold with only ∼100 nanoparticles. The combination with a tetracysteine-tagged form of alpha-synuclein specific for fluorogenic biarsenicals constitutes a very sensitive system for studying pathological amyloid formation in cells.
