Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release

HÉCTOR J. PRADO; MARÍA C. MATULEWICZ; PABLO R. BONELLI; ANA L. CUKIERMAN

CARBOHYDRATE RESEARCH

Elsevier Ltd.

Año: 2009 vol. 344 p. 1325 - 1331

0008-6215

A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenan as the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some differences in comparison with either IPEC constituents or physical mixture. The swelling of tablets obtained by direct compression was independent of pH, and a maximum value of 742% was attained after 24 h. The performance of the IPEC as matrix for controlled release of ibuprofen indicates that drug delivery takes place in a zero-order manner. Experimental dissolution data in the buffer stage were properly represented by a model accounting for contributions of Fickian diffusion and relaxation phenomena; this model suggests that the former predominates over the latter, for the modeled range.